INT96924

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Context Info
Confidence 0.49
First Reported 2001
Last Reported 2010
Negated 0
Speculated 1
Reported most in Body
Documents 40
Total Number 42
Disease Relevance 14.50
Pain Relevance 12.32

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Hspg2) extracellular region (Hspg2) proteinaceous extracellular matrix (Hspg2)
extracellular matrix organization (Hspg2)
Anatomy Link Frequency
retina 1
neurons 1
paw 1
internal 1
nociceptor 1
Hspg2 (Mus musculus)
Pain Link Frequency Relevance Heat
Kinase C 141 100.00 Very High Very High Very High
opioid receptor 3 100.00 Very High Very High Very High
depression 55 99.92 Very High Very High Very High
Inflammatory mediators 23 99.88 Very High Very High Very High
nociceptor 85 99.66 Very High Very High Very High
Nerve growth factor 48 99.24 Very High Very High Very High
qutenza 484 99.18 Very High Very High Very High
substance P 69 99.16 Very High Very High Very High
Hyperalgesia 99 98.68 Very High Very High Very High
Morphine 18 98.46 Very High Very High Very High
Disease Link Frequency Relevance Heat
Depression 55 99.92 Very High Very High Very High
INFLAMMATION 221 99.68 Very High Very High Very High
Stress 243 99.54 Very High Very High Very High
Bullous Skin Disease 304 99.04 Very High Very High Very High
Apoptosis 290 98.92 Very High Very High Very High
Heat Stress Disorders 2 98.76 Very High Very High Very High
Hyperalgesia 187 98.68 Very High Very High Very High
Nociception 223 98.42 Very High Very High Very High
Pain 424 98.28 Very High Very High Very High
Injury 155 97.24 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
M U73122 before (5 min), during and after CCL2 application, the evoked calcium mobilization was significantly blocked (p < 0.05, n = 6 cells, Figure 3G) suggesting that activation of the PLC/IP3 pathways is necessary for the CCR2 function in DRG neurons from CCI rats.


Positive_regulation (activation) of PLC in neurons associated with eae
1) Confidence 0.49 Published 2010 Journal Mol Pain Section Body Doc Link PMC3009975 Disease Relevance 0.80 Pain Relevance 0.42
Furthermore, we report that the dADP is mediated by a nonselective cation channel current that is dependent on intracellular Ca2+ and IP3 receptor function, which suggests that the dADP is activated through a Gq/PLC coupled signaling pathway.
Positive_regulation (activated) of PLC
2) Confidence 0.49 Published 2007 Journal PLoS ONE Section Body Doc Link PMC1892805 Disease Relevance 0 Pain Relevance 0.23
We have examined in vivo whether morphine, at an extremely low dose, induces acute central hypernociception following activation of the opioid receptor-mediated PLC/PKC inositol-lipid signaling pathway.
Spec (whether) Positive_regulation (activation) of PLC associated with opioid receptor and morphine
3) Confidence 0.45 Published 2006 Journal Pain Section Abstract Doc Link 16650582 Disease Relevance 0.31 Pain Relevance 0.75
Not surprisingly therefore signal transduction involves Ca2+-dependent pathways including activation of protein kinase C, calcium-calmodulin-dependent protein kinase II (CaMKII), protein kinase A (PKA) phospholipase C (PLC), inositoltriphosphate-3 (IP3) receptors, nitric oxide synthase (NOS) and members of the mitogen-activated protein kinase family (MAPK), including extracellular signal-regulated kinase (ERK) (Fig. 2) [8,12,18,34-36].
Positive_regulation (activation) of PLC associated with kinase c
4) Confidence 0.45 Published 2007 Journal Mol Pain Section Body Doc Link PMC1852298 Disease Relevance 0.08 Pain Relevance 0.63
Moreover, cytosolic free Ca2+ mobilized from the intracellular stores of the ER has been shown to be also a second messenger for NGF-TrkA signaling linked to the activation of PLC-?
Positive_regulation (activation) of PLC
5) Confidence 0.45 Published 2006 Journal BMC Neurosci Section Body Doc Link PMC1775042 Disease Relevance 0.83 Pain Relevance 0.04
The sigma-agonists' nociception is attributed to the substance P (SP) release from nociceptor endings through activations of Galpha(i1) and phospholipase C (PLC).
Positive_regulation (activations) of PLC in nociceptor associated with nociception, nociceptor, agonist and substance p
6) Confidence 0.42 Published 2001 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 11454934 Disease Relevance 0.50 Pain Relevance 0.58
Collectively, these findings indicate that edematogenic responses elicited by PGE2 are mediated by EP3 receptor activation, also involving the stimulation of PLC, PKC, and MAPKs pathways and the participation of TRPV1 and NK1 receptors.
Positive_regulation (stimulation) of PLC in PGE2 associated with kinase c
7) Confidence 0.24 Published 2006 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 16644903 Disease Relevance 0.34 Pain Relevance 0.39
subunit required for the PLC?
Positive_regulation (required) of PLC
8) Confidence 0.18 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2912856 Disease Relevance 0 Pain Relevance 0.09
Disruption of interaction between phosphatidylinositol-4, 5-bisphosphate (PIP2) and TRPV1 has also been reported to be involved in the sensitization of TRPV1 downstream of PLC activation [45,46].
Positive_regulation (activation) of PLC
9) Confidence 0.17 Published 2005 Journal Mol Pain Section Body Doc Link PMC1074353 Disease Relevance 0.20 Pain Relevance 0.34
Therefore, the residual Ca2+ response to group-1 mGluR activation in PLC-?
Positive_regulation (activation) of PLC
10) Confidence 0.17 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2770323 Disease Relevance 0 Pain Relevance 0.05
DAG, generated by PLC activation, directly activates TRPC3/C6 [17].
Positive_regulation (activation) of PLC
11) Confidence 0.13 Published 2010 Journal Basic Res Cardiol Section Body Doc Link PMC2916114 Disease Relevance 0 Pain Relevance 0
This medium-duration ADP is rapidly and reversibly induced by activation of mGluR5 and requires activation of phospholipase C (PLC) and release of calcium from internal stores.
Positive_regulation (activation) of PLC in internal
12) Confidence 0.12 Published 2010 Journal PLoS Biology Section Abstract Doc Link PMC2982802 Disease Relevance 0 Pain Relevance 0.43
When U73122 was included in the pipette solution, PGI2 (1.5 min) failed to potentiate the currents whereas U73343 exhibited no such effects, indicating the involvement of PLC activation in the potentiating process (0.97 ± 0.40 fold increase, n = 9 for U73122, 2.58 ± 0.66 fold, n = 5 for U73343, p < 0.05) (Figure 5B).
Positive_regulation (activation) of PLC
13) Confidence 0.11 Published 2005 Journal Mol Pain Section Body Doc Link PMC1074353 Disease Relevance 0.06 Pain Relevance 0.32
Our recent data exhibited that PMA raised intracellular Ca2+ concentration by activating PKC through PLC (unpublished results).
Positive_regulation (activating) of PLC associated with kinase c
14) Confidence 0.11 Published 2007 Journal International Journal of Biological Sciences Section Body Doc Link PMC1865092 Disease Relevance 0.07 Pain Relevance 0.31
Regardless, we show that after PLC and PKA pathway activation (which sensitizes nociceptors, including TRPV1 and TRPA1 – see below), injections of two chemically distinct NO donors in the paw cause nociceptive behavior.
Positive_regulation (activation) of PLC in paw associated with nociception and nociceptor
15) Confidence 0.10 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2764051 Disease Relevance 1.15 Pain Relevance 1.04
1-ARs in different organs must imply the activation of multiple signaling pathways beyond activation of PLC via Gq/11.
Positive_regulation (activation) of PLC
16) Confidence 0.10 Published 2010 Journal Journal of Receptor and Signal Transduction Research Section Body Doc Link PMC3018134 Disease Relevance 0 Pain Relevance 0
The increase in intracellular calcium level may serve as an indicator of PLC activation and a cofactor for PKC activation after PMA treatment.
Positive_regulation (activation) of PLC associated with kinase c
17) Confidence 0.09 Published 2007 Journal International Journal of Biological Sciences Section Body Doc Link PMC1865092 Disease Relevance 0.07 Pain Relevance 0.32
Activation of PLC-coupled mGluR results in IP3-mediated release of Ca2+ by intracellular stores [37].
Positive_regulation (Activation) of PLC
18) Confidence 0.09 Published 2007 Journal PLoS ONE Section Body Doc Link PMC1933592 Disease Relevance 0.80 Pain Relevance 0.61
Furthermore, a number of publications showed that activation of PLC-PI3K-AKT signaling led to apoptosis arrest in neurodegeneration [31] and atherosclerosis [32].
Positive_regulation (activation) of PLC associated with increased venous pressure under development and apoptosis
19) Confidence 0.08 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2515219 Disease Relevance 0.67 Pain Relevance 0
Induction of Hsp/c70 might proceed via PLC dependent PKC activation as previously described for a heat stress model [33].
Positive_regulation (activation) of PLC associated with heat stress disorders
20) Confidence 0.08 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2515219 Disease Relevance 0.66 Pain Relevance 0

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