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Context Info
Confidence 0.03
First Reported 2001
Last Reported 2001
Negated 0
Speculated 0
Reported most in Abstract
Documents 1
Total Number 1
Disease Relevance 0.09
Pain Relevance 0.09

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cytosol (Alox5) nuclear envelope (Alox5) oxidoreductase activity (Alox5)
nucleus (Alox5) cytoplasm (Alox5)
Alox5 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
cINOD 1 86.48 High High
Disease Link Frequency Relevance Heat
INFLAMMATION 1 86.24 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In our attempt to characterize the stimulating constituents, we identified the tetracyclic triterpene 3-oxo-tirucallic acid (3-oxo-TA), which, in the range from 2.5 to 15 microM, enhanced 5-LO product formation in ionophore-challenged polymorphonuclear cells (PMNs) (e.g., from 1981 +/- 177 to 3042 +/- 208 pmol at 10 microM 3-oxo-TA), and initiated Ca(2+) mobilization, MEK-1/2 phosphorylation, 5-LO translocation, and 5-LO product formation in resting cells (534 +/- 394 pmol/5 x 10(6) PMNs).
Positive_regulation (enhanced) of 5-LO Binding (formation) of
1) Confidence 0.03 Published 2001 Journal Mol. Pharmacol. Section Abstract Doc Link 11455013 Disease Relevance 0.09 Pain Relevance 0.09

General Comments

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