INT96930

Context Info Confidence 0.43 First Reported 2001 Last Reported 2004 Negated 1 Speculated 0 Reported most in Abstract Documents 2 Total Number 2 Disease Relevance 0.15 Pain Relevance 0.23

cytosol (Alox5) nuclear envelope (Alox5) oxidoreductase activity (Alox5) nucleus (Alox5) cytoplasm (Alox5)

Anatomy Link Frequency sensory neurons 2 Alox5 (Rattus norvegicus)

Pain Link Frequency Relevance Heat antagonist 2 91.68 Root ganglion neuron 1 83.64 bradykinin 1 69.20 c fibre 1 61.68 cINOD 1 48.28 qutenza 2 25.00 nociceptor 2 25.00

Disease Link Frequency Relevance Heat Ganglion Cysts 1 83.32 Pruritus 2 62.28 INFLAMMATION 1 48.04

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

We thus conclude that histamine activates TRPV1 after stimulating the PLA(2)/LO pathway, leading to the excitation of sensory neurons.

Positive_regulation (stimulating) of Positive_regulation (leading) of LO in sensory neurons

1) Confidence 0.43 Published 2004 Journal Neurosci. Lett. Section Abstract Doc Link 15135918 Disease Relevance 0.15 Pain Relevance 0.23

Steroid-type tetracycles neither induced 5-LO activation nor had enhancing or inhibitory effects.

Neg (neither) Positive_regulation (induced) of Neg (neither) Positive_regulation (activation) of 5-LO

2) Confidence 0.03 Published 2001 Journal Mol. Pharmacol. Section Abstract Doc Link 11455013 Disease Relevance 0 Pain Relevance 0

General Comments

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