INT96930

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Context Info
Confidence 0.43
First Reported 2001
Last Reported 2004
Negated 1
Speculated 0
Reported most in Abstract
Documents 2
Total Number 2
Disease Relevance 0.15
Pain Relevance 0.23

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Alox5) nuclear envelope (Alox5) oxidoreductase activity (Alox5)
nucleus (Alox5) cytoplasm (Alox5)
Anatomy Link Frequency
sensory neurons 2
Alox5 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
antagonist 2 91.68 High High
Root ganglion neuron 1 83.64 Quite High
bradykinin 1 69.20 Quite High
c fibre 1 61.68 Quite High
cINOD 1 48.28 Quite Low
qutenza 2 25.00 Low Low
nociceptor 2 25.00 Low Low
Disease Link Frequency Relevance Heat
Ganglion Cysts 1 83.32 Quite High
Pruritus 2 62.28 Quite High
INFLAMMATION 1 48.04 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
We thus conclude that histamine activates TRPV1 after stimulating the PLA(2)/LO pathway, leading to the excitation of sensory neurons.
Positive_regulation (stimulating) of Positive_regulation (leading) of LO in sensory neurons
1) Confidence 0.43 Published 2004 Journal Neurosci. Lett. Section Abstract Doc Link 15135918 Disease Relevance 0.15 Pain Relevance 0.23
Steroid-type tetracycles neither induced 5-LO activation nor had enhancing or inhibitory effects.
Neg (neither) Positive_regulation (induced) of Neg (neither) Positive_regulation (activation) of 5-LO
2) Confidence 0.03 Published 2001 Journal Mol. Pharmacol. Section Abstract Doc Link 11455013 Disease Relevance 0 Pain Relevance 0

General Comments

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