INT96931

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Context Info
Confidence 0.14
First Reported 2001
Last Reported 2006
Negated 0
Speculated 0
Reported most in Abstract
Documents 2
Total Number 2
Disease Relevance 0.46
Pain Relevance 0.12

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Alox5) nuclear envelope (Alox5) oxidoreductase activity (Alox5)
nucleus (Alox5) cytoplasm (Alox5)
Anatomy Link Frequency
brain 2
Alox5 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
ischemia 21 67.36 Quite High
cINOD 2 62.72 Quite High
Inflammation 22 5.00 Very Low Very Low Very Low
Bioavailability 4 5.00 Very Low Very Low Very Low
Inflammatory mediators 4 5.00 Very Low Very Low Very Low
Inflammatory response 3 5.00 Very Low Very Low Very Low
cytokine 2 5.00 Very Low Very Low Very Low
ketamine 1 5.00 Very Low Very Low Very Low
anesthesia 1 5.00 Very Low Very Low Very Low
alcohol 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Brain Hemorrhage 8 99.60 Very High Very High Very High
Injury 22 97.64 Very High Very High Very High
Middle Cerebral Artery Infarction 7 81.12 Quite High
Cv Unclassified Under Development 13 67.36 Quite High
INFLAMMATION 31 62.48 Quite High
Infarction 8 40.72 Quite Low
Stroke 17 5.00 Very Low Very Low Very Low
Death 6 5.00 Very Low Very Low Very Low
Cv General 4 Under Development 3 5.00 Very Low Very Low Very Low
Disease 3 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Treatment with 5-LOX inhibitors improves brain infarction and neurological score after IR injury
Negative_regulation (inhibitors) of 5-LOX Binding (Treatment) of in brain associated with brain hemorrhage and injury
1) Confidence 0.14 Published 2006 Journal J Neuroinflammation Section Body Doc Link PMC1526713 Disease Relevance 0.40 Pain Relevance 0.06
In 3-oxo-TA-challenged PMNs, the mitogen-activated protein kinase kinase (MEK)-1/2 inhibitor PD098059 abolished 5-LO product formation, along with inhibition of MEK-1/2 phosphorylation and 5-LO translocation.
Negative_regulation (abolished) of 5-LO Binding (formation) of
2) Confidence 0.03 Published 2001 Journal Mol. Pharmacol. Section Abstract Doc Link 11455013 Disease Relevance 0.06 Pain Relevance 0.06

General Comments

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