INT96937

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Context Info
Confidence 0.75
First Reported 2001
Last Reported 2011
Negated 3
Speculated 4
Reported most in Body
Documents 191
Total Number 196
Disease Relevance 150.30
Pain Relevance 56.01

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

peptidase activity (Mmp9) extracellular space (Mmp9) extracellular region (Mmp9)
proteinaceous extracellular matrix (Mmp9) extracellular matrix organization (Mmp9) protein complex (Mmp9)
Anatomy Link Frequency
fibroblasts 21
macrophages 7
neutrophils 7
lung 7
skin 6
Mmp9 (Mus musculus)
Pain Link Frequency Relevance Heat
metalloproteinase 3604 100.00 Very High Very High Very High
Inflammation 2678 100.00 Very High Very High Very High
cytokine 1297 100.00 Very High Very High Very High
Inflammatory mediators 133 100.00 Very High Very High Very High
Hippocampus 21 100.00 Very High Very High Very High
COX2 2 99.96 Very High Very High Very High
Central nervous system 507 99.84 Very High Very High Very High
Paracetamol 29 99.82 Very High Very High Very High
fibrosis 1263 99.76 Very High Very High Very High
Snapping jaw 24 99.76 Very High Very High Very High
Disease Link Frequency Relevance Heat
INFLAMMATION 3208 100.00 Very High Very High Very High
Cancer 2268 100.00 Very High Very High Very High
Apoptosis 589 100.00 Very High Very High Very High
Adhesions 584 100.00 Very High Very High Very High
Necrosis 326 100.00 Very High Very High Very High
Stress 220 100.00 Very High Very High Very High
Systemic Sclerosis 2211 99.98 Very High Very High Very High
Bacterial Meningitis 25 99.98 Very High Very High Very High
Lung Injury 164 99.92 Very High Very High Very High
Fibrosis 1178 99.84 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In rodents, MMP-2, MMP-3, MMP-9, MMP-13, MMP-14, as well as TIMP-1 and TIMP-2 are expressed in early stages of HSC activation and have been implicated in fibrogenesis as well as fibrolysis (reviewed in [20]).
Gene_expression (expressed) of MMP-9 associated with fibrosis
1) Confidence 0.75 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2892485 Disease Relevance 0.89 Pain Relevance 0.31
In the present study, we measured the expression of MMP-9 and tissue inhibitor of metalloproteinase-1 (TIMP-1), an inhibitor of MMP-9, in the sera and culture supernatants of dermal fibroblasts from SSc patients and compared them with serum concentrations of transforming growth factor ?
Gene_expression (expression) of MMP-9 in fibroblasts associated with metalloproteinase and systemic sclerosis
2) Confidence 0.72 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1064883 Disease Relevance 1.40 Pain Relevance 0.41
Moreover, the overexpression of MMP-9 has been reported in various pathologic conditions characterized by excessive fibrosis, including idiopathic pulmonary fibrosis, bronchial asthma, experimental biliary cirrhosis, and chronic pancreatitis [20-23], suggesting that elevated MMP-9 is closely linked to fibrogenic remodeling in target organs.
Gene_expression (overexpression) of MMP-9 associated with asthma, fibrosis, cirrhosis, pulmonary fibrosis and chronic pancreatitis
3) Confidence 0.72 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1064883 Disease Relevance 1.73 Pain Relevance 0.46
In this study, we investigated the expression of MMP-9 and its clinical significance in systemic sclerosis (SSc).
Spec (investigated) Gene_expression (expression) of MMP-9 associated with systemic sclerosis
4) Confidence 0.72 Published 2005 Journal Arthritis Res Ther Section Abstract Doc Link PMC1064883 Disease Relevance 0.79 Pain Relevance 0.18
Furthermore, the disc and articular cells express MMP9 and IL-1.
Gene_expression (express) of MMP9 in articular
5) Confidence 0.66 Published 2001 Journal Cells Tissues Organs (Print) Section Abstract Doc Link 11455120 Disease Relevance 0.75 Pain Relevance 0.76
We describe the presence of a matrix metalloproteinase, MMP9 (92-kD gelatinase), in TMJ disc and articular cells that likely function in the degradative process.
Gene_expression (presence) of 92-kD gelatinase in TMJ associated with snapping jaw and metalloproteinase
6) Confidence 0.65 Published 2001 Journal Cells Tissues Organs (Print) Section Abstract Doc Link 11455120 Disease Relevance 0.68 Pain Relevance 0.82
Given that Marimastat efficiently inhibits MMP-9 activity (Figure 6), Mmp9 homozygous null mice (Mmp9?
Gene_expression (activity) of MMP-9
7) Confidence 0.65 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2892485 Disease Relevance 0.99 Pain Relevance 0.21
Given that Marimastat efficiently inhibits MMP-9 activity (Figure 6), Mmp9 homozygous null mice (Mmp9?
Gene_expression (homozygous) of Mmp9
8) Confidence 0.65 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2892485 Disease Relevance 0.98 Pain Relevance 0.21
Acetaminophen-induced expression of MCP-1, IL-1beta, CTGF, and MMP-9 mRNA was also delayed or reduced in TNFR1(-/-) mice relative to wild-type mice.
Gene_expression (expression) of MMP-9 mRNA associated with paracetamol
9) Confidence 0.64 Published 2003 Journal Toxicol. Appl. Pharmacol. Section Abstract Doc Link 14550746 Disease Relevance 0.89 Pain Relevance 0.84
Expression of macrophage chemotactic protein-1 (MCP-1), KC/gro, interleukin-1beta (IL-1beta), matrix metalloproteinase-9 (MMP-9), and connective tissue growth factor (CTGF), inflammatory mediators known to participate in tissue repair, as well as the anti-inflammatory cytokine, interleukin-10 (IL-10), also increased in the liver following acetaminophen administration.
Gene_expression (Expression) of matrix metalloproteinase-9 in connective tissue associated with paracetamol, inflammatory mediators, inflammation, metalloproteinase and cytokine
10) Confidence 0.64 Published 2003 Journal Toxicol. Appl. Pharmacol. Section Abstract Doc Link 14550746 Disease Relevance 1.10 Pain Relevance 0.76
Our goal was to determine, in a murine model, whether matrix metalloproteinase-9 (MMP-9), a known protease of IGFBP-3, is responsible for the postoperative decrease in serum IGFBP-3 levels.
Gene_expression (protease) of MMP-9 associated with metalloproteinase
11) Confidence 0.64 Published 2005 Journal Surgical innovation Section Abstract Doc Link 16424954 Disease Relevance 0.19 Pain Relevance 0.20
MCP-1, ICAM-1 and MMP-9 were measured using commercially available ELISA kits from R&D systems, UK.
Gene_expression (measured) of MMP-9 associated with metalloproteinase
12) Confidence 0.63 Published 2007 Journal International Journal of Medical Sciences Section Body Doc Link PMC1868659 Disease Relevance 0.09 Pain Relevance 0.09
Moreover, dermal fibroblasts from patients with SSc produced more MMP-9 than those from healthy controls when they were stimulated with IL-1?
Gene_expression (produced) of MMP-9 in fibroblasts associated with systemic sclerosis
13) Confidence 0.62 Published 2005 Journal Arthritis Res Ther Section Abstract Doc Link PMC1064883 Disease Relevance 1.04 Pain Relevance 0.15
These findings show that one of the sources for MMP-9 production in SSc is dermal fibroblasts.
Gene_expression (production) of MMP-9 in fibroblasts associated with systemic sclerosis
14) Confidence 0.62 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1064883 Disease Relevance 1.06 Pain Relevance 0.14
In SSc, several proinflammatory cytokines activate fibroblasts to increase MMP-9 production, as depicted in Fig. 5.
Gene_expression (production) of MMP-9 in fibroblasts associated with systemic sclerosis and cytokine
15) Confidence 0.62 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1064883 Disease Relevance 1.60 Pain Relevance 0.49
Such an increase in MMP-9 production was partially blocked by treatment with cyclosporin A.
Gene_expression (production) of MMP-9
16) Confidence 0.62 Published 2005 Journal Arthritis Res Ther Section Abstract Doc Link PMC1064883 Disease Relevance 1.01 Pain Relevance 0.14
increases the production of MMP-9 in several cell types, possibly through a process requiring protein synthesis that leads to increased statility of MMP-9 mRNA [40,41].
Gene_expression (production) of MMP-9
17) Confidence 0.62 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1064883 Disease Relevance 1.33 Pain Relevance 0.25
-induced MMP-9 production by SSc fibroblasts.
Gene_expression (production) of MMP-9 in fibroblasts associated with systemic sclerosis
18) Confidence 0.62 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1064883 Disease Relevance 1.07 Pain Relevance 0.13
Expression of VEGF or MMP-9 and IL-1?
Gene_expression (Expression) of MMP-9
19) Confidence 0.61 Published 2010 Journal Molecular Vision Section Body Doc Link PMC2830023 Disease Relevance 0.41 Pain Relevance 0.20
In fibrotic animals, hepatic expression of MMP-2, MMP-3, MMP-8, MMP-9 and MMP-13 mRNA were all significantly upregulated, compared to non-fibrotic controls (Figure 6).
Gene_expression (expression) of MMP-9 associated with fibrosis
20) Confidence 0.58 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2892485 Disease Relevance 0.33 Pain Relevance 0.06

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