INT9694

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Context Info
Confidence 0.68
First Reported 1982
Last Reported 2011
Negated 3
Speculated 3
Reported most in Abstract
Documents 102
Total Number 105
Disease Relevance 70.09
Pain Relevance 33.07

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Csf2) extracellular region (Csf2)
Anatomy Link Frequency
macrophage 12
CSF 12
brain 2
Kupffer cell 2
lymphocytes 2
Csf2 (Mus musculus)
Pain Link Frequency Relevance Heat
Inflammation 1067 100.00 Very High Very High Very High
cytokine 853 100.00 Very High Very High Very High
Multiple sclerosis 597 100.00 Very High Very High Very High
chemokine 548 100.00 Very High Very High Very High
Opioid 55 100.00 Very High Very High Very High
Antinociceptive 27 100.00 Very High Very High Very High
opiate 21 100.00 Very High Very High Very High
antinociception 4 100.00 Very High Very High Very High
Morphine 43 99.98 Very High Very High Very High
Glutamate 66 99.96 Very High Very High Very High
Disease Link Frequency Relevance Heat
INFLAMMATION 1125 100.00 Very High Very High Very High
Demyelinating Disease 714 100.00 Very High Very High Very High
Pulmonary Alveolar Proteinosis 442 100.00 Very High Very High Very High
Failure To Thrive 39 99.88 Very High Very High Very High
Disease 1510 99.84 Very High Very High Very High
Injury 144 99.74 Very High Very High Very High
Atherosclerosis 38 99.68 Very High Very High Very High
Recurrence 93 99.60 Very High Very High Very High
Disorder Of Lipid Metabolism 25 99.60 Very High Very High Very High
Glioblastoma 200 99.56 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
From these results, it appears obvious that the development and differentiation of LC do not require M-CSF.
Neg (not) Positive_regulation (require) of M-CSF
1) Confidence 0.68 Published 1992 Journal J. Invest. Dermatol. Section Abstract Doc Link 1431208 Disease Relevance 0.13 Pain Relevance 0.11
The injection of various doses of morphine caused a dose responsive increase in opiate-like material in rabbit CSF taken at the peak of activity (60 min later).
Spec (like) Positive_regulation (increase) of CSF associated with opiate and morphine
2) Confidence 0.68 Published 1982 Journal Life Sci. Section Abstract Doc Link 7154834 Disease Relevance 0 Pain Relevance 1.21
Morphine also caused an increase in opiate activity in dog CSF.
Positive_regulation (increase) of CSF associated with opiate and morphine
3) Confidence 0.68 Published 1982 Journal Life Sci. Section Abstract Doc Link 7154834 Disease Relevance 0 Pain Relevance 1.33
Most interesting, however, was the finding that PGE2 and PGE1 could act synergistically with IL-2 for the induction of GM-CSF in some TH1 clones.
Positive_regulation (induction) of GM-CSF
4) Confidence 0.66 Published 1989 Journal J. Immunol. Section Abstract Doc Link 2521509 Disease Relevance 0.06 Pain Relevance 0.05
As was found with PGE2, these compounds also induced GM-CSF activity in the presence of IL-2, suggesting a critical role for cAMP in this process.
Positive_regulation (induced) of GM-CSF
5) Confidence 0.66 Published 1989 Journal J. Immunol. Section Abstract Doc Link 2521509 Disease Relevance 0.10 Pain Relevance 0.10
Intrathecal administration of guanosine (200 nmol) induced an approximately 120-fold increase on CSF guanosine levels.
Positive_regulation (increase) of CSF in CSF associated with intrathecal
6) Confidence 0.60 Published 2009 Journal Eur. J. Pharmacol. Section Abstract Doc Link 19379722 Disease Relevance 0.20 Pain Relevance 0.98
Quantitation of radioactivity in CSF after the injection of radiolabelled morphine, stability studies and other assays were used to rule out the possibility that the increased activity in CSF was due to morphine itself.
Positive_regulation (increased) of CSF associated with morphine
7) Confidence 0.59 Published 1982 Journal Life Sci. Section Abstract Doc Link 7154834 Disease Relevance 0 Pain Relevance 1.55
Pentazocine (25-75 mg/kg) also significantly increased opioid-like activity in rabbit CSF, but the effects of methadone (5-10 mg/kg) and levorphanol (20 mg/kg) were less marked.
Positive_regulation (increased) of CSF in CSF associated with fortral, methadone and opioid
8) Confidence 0.58 Published 1985 Journal Life Sci. Section Abstract Doc Link 4079662 Disease Relevance 0 Pain Relevance 1.49
Several studies have suggested that F2-isoprostanes, a group of isoprostanes, are increased in CSF of AD patients compared to healthy control or patients with other dementia [125, 126].
Positive_regulation (increased) of CSF associated with dementia and disease
9) Confidence 0.55 Published 2010 Journal International Journal of Alzheimer's Disease Section Body Doc Link PMC2915796 Disease Relevance 1.66 Pain Relevance 0.10
Significant increases in cytokines, such as interleukin (IL)-1beta, IL-6 and granulocyte macrophage colony stimulating factor (GM-CSF), and in chemokines, such as macrophage chemotactic protein 1 (MCP-1), macrophage inflammatory protein 1 (MIP-1alpha) and Kupffer cell derived chemokine (KC), were detected, with no changes in T-cell-derived cytokines.
Positive_regulation (increases) of GM-CSF in Kupffer cell associated with chemokine, inflammation and cytokine
10) Confidence 0.53 Published 2007 Journal Neurogastroenterol. Motil. Section Abstract Doc Link 17509021 Disease Relevance 0.52 Pain Relevance 0.65
Significant increases in cytokines, such as interleukin (IL)-1beta, IL-6 and granulocyte macrophage colony stimulating factor (GM-CSF), and in chemokines, such as macrophage chemotactic protein 1 (MCP-1), macrophage inflammatory protein 1 (MIP-1alpha) and Kupffer cell derived chemokine (KC), were detected, with no changes in T-cell-derived cytokines.
Positive_regulation (increases) of granulocyte macrophage colony stimulating factor in Kupffer cell associated with chemokine, inflammation and cytokine
11) Confidence 0.53 Published 2007 Journal Neurogastroenterol. Motil. Section Abstract Doc Link 17509021 Disease Relevance 0.52 Pain Relevance 0.65
Bone marrow cells from mice implanted with morphine pellets for 72 h showed a 65% decrease in their response to macrophage colony stimulating factor (M-CSF).
Positive_regulation (response) of M-CSF in macrophage associated with morphine
12) Confidence 0.50 Published 1991 Journal Eur. J. Pharmacol. Section Abstract Doc Link 1831136 Disease Relevance 0 Pain Relevance 0.75
The recent study by the Swiss group also supports a positive effect of GM-CSF on CD4+ lymphocytes count [18].
Positive_regulation (effect) of GM-CSF in lymphocytes
13) Confidence 0.50 Published 2005 Journal J Immune Based Ther Vaccines Section Body Doc Link PMC1164429 Disease Relevance 0.13 Pain Relevance 0
The augmentation of GM-CSF with LPS appears to be mediated by the same mechanism involved in LPS-induced inflammation.
Positive_regulation (augmentation) of GM-CSF associated with inflammation
14) Confidence 0.49 Published 2008 Journal Journal of Korean Medical Science Section Body Doc Link PMC2526424 Disease Relevance 0.78 Pain Relevance 0.46
Intracerebroventricular administration of guanosine and GMP induced, respectively, a 180- and 1800-fold increase on CSF guanosine levels.
Positive_regulation (increase) of CSF associated with intracerebroventricular
15) Confidence 0.48 Published 2008 Journal Brain Res. Section Abstract Doc Link 18708036 Disease Relevance 0.18 Pain Relevance 1.14
Therefore, overstimulation of the GM-CSF-system as found in our patient may present the underlying trigger of adverse extracellular matrix remodeling, loss of functional texture (in the areas of persistent inflammation) and thus contribute to the destabilization of the aortic wall finally leading to aortic dissection.
Positive_regulation (overstimulation) of GM-CSF in extracellular matrix associated with inflammation
16) Confidence 0.45 Published 2010 Journal J Cardiothorac Surg Section Body Doc Link PMC2933604 Disease Relevance 0.42 Pain Relevance 0.17
It has been proven that squid ink could induce many cytokines, such as IL-4 [17] and colony stimulating factor (CSF) [14].
Positive_regulation (induce) of CSF associated with cytokine
17) Confidence 0.44 Published 2009 Journal Marine Drugs Section Body Doc Link PMC2666885 Disease Relevance 0.14 Pain Relevance 0.05
Prostaglandin E2-dependent induction of granulocyte-macrophage colony-stimulating factor secretion by cloned murine helper T cells.
Positive_regulation (induction) of granulocyte-macrophage colony-stimulating factor in helper T cells
18) Confidence 0.44 Published 1989 Journal J. Immunol. Section Title Doc Link 2521509 Disease Relevance 0.06 Pain Relevance 0.04
GM-CSF is induced by Th17 cells and drives myeloid cell mobilization and differentiation during inflammation (18).
Positive_regulation (induced) of GM-CSF in myeloid cell associated with inflammation
19) Confidence 0.43 Published 2008 Journal The Journal of Experimental Medicine Section Body Doc Link PMC2442630 Disease Relevance 0.89 Pain Relevance 0.31
Remarkably, exceeding matrix deterioration was associated with massively increased levels of granulocyte macrophage colony stimulating factor (GM-CSF).


Positive_regulation (increased) of GM-CSF in macrophage
20) Confidence 0.42 Published 2010 Journal J Cardiothorac Surg Section Abstract Doc Link PMC2933604 Disease Relevance 0.70 Pain Relevance 0.12

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