INT9695

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Context Info
Confidence 0.57
First Reported 1992
Last Reported 2011
Negated 0
Speculated 2
Reported most in Body
Documents 41
Total Number 43
Disease Relevance 31.65
Pain Relevance 6.28

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Csf2) extracellular region (Csf2)
Anatomy Link Frequency
neutrophil 3
brain 2
alveolar macrophages 2
plaque 2
macrophage 1
Csf2 (Mus musculus)
Pain Link Frequency Relevance Heat
Inflammation 519 100.00 Very High Very High Very High
cytokine 265 100.00 Very High Very High Very High
rheumatoid arthritis 89 100.00 Very High Very High Very High
dexamethasone 96 99.84 Very High Very High Very High
depression 29 99.76 Very High Very High Very High
Multiple sclerosis 177 98.92 Very High Very High Very High
imagery 196 98.20 Very High Very High Very High
headache 10 98.04 Very High Very High Very High
Opioid 4 97.46 Very High Very High Very High
ketamine 9 97.04 Very High Very High Very High
Disease Link Frequency Relevance Heat
INFLAMMATION 568 100.00 Very High Very High Very High
Acquired Immune Deficiency Syndrome Or Hiv Infection 235 100.00 Very High Very High Very High
Rheumatoid Arthritis 95 100.00 Very High Very High Very High
Pulmonary Alveolar Proteinosis 116 99.76 Very High Very High Very High
Depression 30 99.76 Very High Very High Very High
Syndrome 48 99.64 Very High Very High Very High
Convulsion 12 99.64 Very High Very High Very High
Disease 1426 99.42 Very High Very High Very High
Cognitive Disorder 265 99.38 Very High Very High Very High
Congenital Anomalies 18 99.24 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Mice genetically deficient in granulocyte macrophagecolony stimulating factor (GM-CSF) show an alveolar proteinosis.
Negative_regulation (deficient) of GM-CSF in granulocyte associated with pulmonary alveolar proteinosis
1) Confidence 0.57 Published 2003 Journal Rev Med Chir Soc Med Nat Iasi Section Abstract Doc Link 14756054 Disease Relevance 1.14 Pain Relevance 0.09
Homozygotes (op/op) lack M-CSF activity and show abnormalities in the differentiation of osteoclasts and other cells within the macrophage lineage.
Negative_regulation (lack) of M-CSF in osteoclasts associated with congenital anomalies
2) Confidence 0.42 Published 1992 Journal J. Invest. Dermatol. Section Abstract Doc Link 1431208 Disease Relevance 0.27 Pain Relevance 0.06
A number of antiretroviral drugs may be effective in the treatment of ADC, based upon reduction of HIV-1 RNA in the CSF, as seen with stavudine (d4T), lamivudine (3TC) [9], and indinavir [10]; the measurement of potentially efficacious drug concentrations in the CSF, as observed with nevirapine and efavirenz [11,12]; and efficacy in in vitro models (d4T, 3TC, and efavirenz) [13].
Negative_regulation (reduction) of CSF associated with acquired immune deficiency syndrome or hiv infection
3) Confidence 0.40 Published 2007 Journal PLoS Clinical Trials Section Body Doc Link PMC1845158 Disease Relevance 0.48 Pain Relevance 0
Deposition of the peptide in plaquesamyloid sinks”) is considered the underlying basis for the decrease of CSF-A?
Negative_regulation (decrease) of CSF in plaques associated with alzheimer's dementia
4) Confidence 0.39 Published 2010 Journal International Journal of Alzheimer's Disease Section Body Doc Link PMC2915796 Disease Relevance 0.83 Pain Relevance 0.04
USA 95 (1998) 3239] that in patients with severe depression there is a decrease in the CSF levels of 3alpha,5alpha-TH PROG, which is normalized by treatment with drugs (i.e. fluoxetine) that improve psychopathology.
Negative_regulation (decrease) of CSF associated with depression and fluoxetine
5) Confidence 0.36 Published 2001 Journal Brain Res. Brain Res. Rev. Section Abstract Doc Link 11744079 Disease Relevance 0.10 Pain Relevance 0.42
-secretase occurs via nonamyloidogenic pathway, and a reduced CSF level of sAPP?
Negative_regulation (level) of CSF
6) Confidence 0.34 Published 2010 Journal International Journal of Alzheimer's Disease Section Body Doc Link PMC2915796 Disease Relevance 1.04 Pain Relevance 0
Moreover, a combination of more than one biomarker in CSF, such as CSF p-tau, t-tau, and A?
Negative_regulation (biomarker) of CSF
7) Confidence 0.34 Published 2010 Journal International Journal of Alzheimer's Disease Section Body Doc Link PMC2915796 Disease Relevance 1.47 Pain Relevance 0.03
The median CSF HIV-1 RNA was reduced, albeit by a modest 0.64 log10 copies/mL over the 12 wk and ABC was present in the CSF in potentially efficacious concentrations, on average 9-fold greater than the IC50 reported for ABC for the wild-type virus.
Negative_regulation (reduced) of CSF associated with acquired immune deficiency syndrome or hiv infection
8) Confidence 0.29 Published 2007 Journal PLoS Clinical Trials Section Body Doc Link PMC1845158 Disease Relevance 0.53 Pain Relevance 0
If the median reductions in CSF HIV-1 RNA from baseline are estimated using week 12 data (or using week 6 data if week 12 value is missing), the median HIV-1 RNA reduction for the ABC + SBG group of ?
Negative_regulation (reductions) of CSF associated with acquired immune deficiency syndrome or hiv infection
9) Confidence 0.29 Published 2007 Journal PLoS Clinical Trials Section Body Doc Link PMC1845158 Disease Relevance 0.76 Pain Relevance 0
Tyr-MIF, an opioid tetrapeptide (H-Tyr-Pro-Leu-Gly-NH2), demonstrated a dose-dependent inhibition of colony formation at concentrations < 10 uM, inhibiting M-CSF and G-CSF-responsive progenitor cells equally.
Negative_regulation (inhibiting) of M-CSF associated with opioid
10) Confidence 0.27 Published 2002 Journal Int. Immunopharmacol. Section Abstract Doc Link 12013510 Disease Relevance 0 Pain Relevance 0.31
Absolute CSF volume was decreased in patients by about 3.7% (407 ± 76 ml vs. 423 ± 77 ml), and TIV was increased in patients by about 2% (1,494 ± 156 ml vs. 1,465 ± 153 ml), yet, these differences were not significant (P = 0.185 and P = 0.174, respectively) (Fig. 2).
Negative_regulation (decreased) of CSF
11) Confidence 0.23 Published 2008 Journal Pituitary Section Body Doc Link PMC2712618 Disease Relevance 0.48 Pain Relevance 0.04
Second, as far as extractable from cross-sectional data, CSF spaces were decreased first, while TIV continued to increase, giving space to CSF that returned to normal absolute values.
Negative_regulation (decreased) of CSF
12) Confidence 0.23 Published 2008 Journal Pituitary Section Body Doc Link PMC2712618 Disease Relevance 0.56 Pain Relevance 0
Combined treatment with antibiotics and roscovitine thus induces apoptosis in situ and very likely by this mechanism reduces the absolute number of neutrophils in the CSF.
Negative_regulation (reduces) of CSF in neutrophils associated with apoptosis
13) Confidence 0.20 Published 2009 Journal PLoS Pathogens Section Body Doc Link PMC2682662 Disease Relevance 0.59 Pain Relevance 0
A catheter was inserted into the cisterna magna to determine CSF leukocyte counts, as well as relative proportions of leucocyte subpopulations and apoptotic leucocytes.
Spec (determine) Negative_regulation (determine) of CSF in leucocytes associated with apoptosis
14) Confidence 0.20 Published 2009 Journal PLoS Pathogens Section Body Doc Link PMC2682662 Disease Relevance 0.62 Pain Relevance 0.30
Homozygous osteopetrotic (Op/Op) mice, deficient in macrophage colony-stimulating factor (m-CSF), exhibit reduced inflammation.
Negative_regulation (deficient) of m-CSF in macrophage associated with inflammation
15) Confidence 0.20 Published 2007 Journal Am. J. Physiol. Heart Circ. Physiol. Section Abstract Doc Link 17142347 Disease Relevance 0.72 Pain Relevance 0.21
Despite the small number of patients we found dexamethasone significantly decreased CSF MMP-9 concentrations early in the course of TBM treatment and thus may represent one mechanism by which corticosteroids improve outcome.
Negative_regulation (decreased) of CSF associated with mycobacterial infection, corticosteroid and dexamethasone
16) Confidence 0.17 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2748711 Disease Relevance 0.78 Pain Relevance 0.42
The restricted release of neutrophil-derived proteins in dexamethasone treated patients may have contributed to the significant reduction in CSF protein observed in the dexamethasone group in the published study involving a larger number of patients from the parent trial [2].
Negative_regulation (reduction) of CSF in neutrophil associated with dexamethasone
17) Confidence 0.17 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2748711 Disease Relevance 0.52 Pain Relevance 0.26
Interestingly, AD patients show a significant decrease in CSF transthyretin levels [159] while decreased transthyretin levels have also been found in blood serum of long-term wireless phone users [158].
Negative_regulation (decrease) of CSF in blood associated with disease
18) Confidence 0.15 Published 2010 Journal International Journal of Alzheimer's Disease Section Body Doc Link PMC2952897 Disease Relevance 0.80 Pain Relevance 0.04
In mice, deficiency of GM-CSF (4, 5) or its receptor (6) impairs multiple functions of alveolar macrophages (7), including surfactant catabolism (8), which results in progressive surfactant accumulation.
Negative_regulation (deficiency) of GM-CSF in alveolar macrophages
19) Confidence 0.13 Published 2008 Journal The Journal of Experimental Medicine Section Body Doc Link PMC2585845 Disease Relevance 0.48 Pain Relevance 0
Mice treated with Ekybion displayed a general trend toward lower cytokine production with significant decreases in GCSF (6.0-fold decrease), GM-CSF (4.0-fold decrease), and IL-6 (3.5-fold decrease) in the 1X 2?
Negative_regulation (decreases) of GM-CSF associated with cytokine
20) Confidence 0.10 Published 2011 Journal Evidence-based Complementary and Alternative Medicine : eCAM Section Body Doc Link PMC2959154 Disease Relevance 0.44 Pain Relevance 0.14

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