INT96951

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Context Info
Confidence 0.34
First Reported 2001
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 5
Total Number 5
Disease Relevance 1.45
Pain Relevance 0.16

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Gclc) ligase activity (Gclc)
Gclc (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Paracetamol 2 86.40 High High
pruritus 2 43.80 Quite Low
Arthritis 4 14.08 Low Low
Inflammation 18 9.52 Low Low
Glutamate 15 5.00 Very Low Very Low Very Low
ischemia 13 5.00 Very Low Very Low Very Low
cytokine 9 5.00 Very Low Very Low Very Low
imagery 6 5.00 Very Low Very Low Very Low
Inflammatory response 4 5.00 Very Low Very Low Very Low
anesthesia 3 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Pancreatitis 240 89.88 High High
Diabetes Mellitus 13 88.96 High High
Hepatotoxicity 3 85.40 High High
Sprains And Strains 24 65.96 Quite High
Bronchospasm 2 58.72 Quite High
Colitis 3 53.88 Quite High
Stress 58 53.52 Quite High
Hypersensitivity 3 49.12 Quite Low
Rhinitis 1 47.28 Quite Low
Pruritus 2 43.80 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Because GCL is composed of both a catalytic and modulatory subunit [37], the increase in GCL activity in this study could be due to enhanced expression of either GCLm and/or GCLc.
Positive_regulation (increase) of Gene_expression (expression) of GCLc
1) Confidence 0.34 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2639703 Disease Relevance 0.36 Pain Relevance 0
On the other hand, we found enhanced GCL activity and expression of the GCL subunits GCLc and GCLm in probiotic-treated animals leading to a significant increase in GSH contents.
Positive_regulation (activity) of Gene_expression (expression) of GCLc
2) Confidence 0.24 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2639703 Disease Relevance 0.23 Pain Relevance 0
Because GCL is composed of both a catalytic and modulatory subunit [37], the increase in GCL activity in this study could be due to enhanced expression of either GCLm and/or GCLc.
Positive_regulation (enhanced) of Gene_expression (expression) of GCLc
3) Confidence 0.23 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2639703 Disease Relevance 0.35 Pain Relevance 0
Furthermore, the activity of y-glutamylcysteine synthetase (gamma-GCS), the rate-limiting enzyme in GSH biosynthesis, was also increased by DCE-GS triester treatment (1.4-fold in 24 h with 1.0 mm).
Positive_regulation (increased) of Gene_expression (biosynthesis) of y-glutamylcysteine synthetase
4) Confidence 0.13 Published 2001 Journal Biol. Pharm. Bull. Section Abstract Doc Link 11456112 Disease Relevance 0.16 Pain Relevance 0.16
The effect of T. cordifolia root extract was better than glibenclamide (600 ยต/kg) although Insulin (6 units/kg) restored all the parameters to normal status.[5354] T. cordifolia has also been reported to elevate GSH levels, expression of the gamma-glutamylcysteine ligase and Cu-Zn SOD genes.
Positive_regulation (elevate) of Gene_expression (expression) of gamma-glutamylcysteine ligase
5) Confidence 0.03 Published 2010 Journal International Journal of Ayurveda Research Section Body Doc Link PMC2924974 Disease Relevance 0.36 Pain Relevance 0

General Comments

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