INT96952

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Context Info
Confidence 0.38
First Reported 2001
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 7
Total Number 7
Disease Relevance 2.08
Pain Relevance 0.28

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Gclc) ligase activity (Gclc)
Gclc (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Paracetamol 3 86.40 High High
methotrexate 1 58.40 Quite High
Multiple sclerosis 4 53.72 Quite High
pruritus 2 43.00 Quite Low
Bioavailability 2 39.52 Quite Low
Arthritis 4 13.28 Low Low
Inflammation 19 8.72 Low Low
Glutamate 23 5.00 Very Low Very Low Very Low
gABA 18 5.00 Very Low Very Low Very Low
Dopamine 14 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Hepatotoxicity 7 99.38 Very High Very High Very High
Diabetes Mellitus 16 88.16 High High
Infection 3 87.76 High High
Pancreatitis 240 87.32 High High
Stress 64 84.40 Quite High
Hepatocellular Cancer 1 83.16 Quite High
Mitochondrial Disorders 5 82.12 Quite High
Cerebellar Diseases 9 72.92 Quite High
Miller Fisher Syndrome 2 68.08 Quite High
Sprains And Strains 24 63.40 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Because GCL is composed of both a catalytic and modulatory subunit [37], the increase in GCL activity in this study could be due to enhanced expression of either GCLm and/or GCLc.
Gene_expression (expression) of GCLc
1) Confidence 0.38 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2639703 Disease Relevance 0.35 Pain Relevance 0
Levels of GCLC and GCLM mRNA were quantified using the comparative threshold cycle method, normalized to18S rRNA expression and expressed as ratio to controls (a.u.).


Gene_expression (Levels) of GCLC
2) Confidence 0.38 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2639703 Disease Relevance 0 Pain Relevance 0
An in vitro drug-induced hepatotoxicity screening system using CYP3A4-expressing and gamma-glutamylcysteine synthetase knockdown cells.
Gene_expression (expressing) of gamma-glutamylcysteine synthetase associated with hepatotoxicity
3) Confidence 0.34 Published 2010 Journal Toxicol In Vitro Section Title Doc Link 19958826 Disease Relevance 0.50 Pain Relevance 0.06
On the other hand, we found enhanced GCL activity and expression of the GCL subunits GCLc and GCLm in probiotic-treated animals leading to a significant increase in GSH contents.
Gene_expression (expression) of GCLc
4) Confidence 0.33 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2639703 Disease Relevance 0.22 Pain Relevance 0
Furthermore, the activity of y-glutamylcysteine synthetase (gamma-GCS), the rate-limiting enzyme in GSH biosynthesis, was also increased by DCE-GS triester treatment (1.4-fold in 24 h with 1.0 mm).
Gene_expression (biosynthesis) of y-glutamylcysteine synthetase
5) Confidence 0.18 Published 2001 Journal Biol. Pharm. Bull. Section Abstract Doc Link 11456112 Disease Relevance 0.16 Pain Relevance 0.16
NAC is rapidly hydrolyzed and under the consecutive effects of gamma-glutamylcysteine synthetase and GSH synthetase, GSH is generated.
Gene_expression (generated) of gamma-glutamylcysteine synthetase
6) Confidence 0.04 Published 2010 Journal Current Neuropharmacology Section Body Doc Link PMC2866461 Disease Relevance 0.49 Pain Relevance 0.06
The effect of T. cordifolia root extract was better than glibenclamide (600 ยต/kg) although Insulin (6 units/kg) restored all the parameters to normal status.[5354] T. cordifolia has also been reported to elevate GSH levels, expression of the gamma-glutamylcysteine ligase and Cu-Zn SOD genes.
Gene_expression (expression) of gamma-glutamylcysteine ligase
7) Confidence 0.03 Published 2010 Journal International Journal of Ayurveda Research Section Body Doc Link PMC2924974 Disease Relevance 0.36 Pain Relevance 0

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