INT96969

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Context Info
Confidence 0.48
First Reported 2001
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 9
Total Number 9
Disease Relevance 1.27
Pain Relevance 7.19

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

aging (CNR1) plasma membrane (CNR1) response to stress (CNR1)
signal transducer activity (CNR1)
Anatomy Link Frequency
dorsal 2
Nucleus 2
spinal cord dorsal horn 2
HCEC 2
CNR1 (Homo sapiens)
Pain Link Frequency Relevance Heat
Cannabinoid 49 100.00 Very High Very High Very High
Cannabinoid receptor 24 100.00 Very High Very High Very High
Analgesic 5 100.00 Very High Very High Very High
analgesia 4 100.00 Very High Very High Very High
neuralgia 4 100.00 Very High Very High Very High
Morphine 14 99.98 Very High Very High Very High
depression 6 99.80 Very High Very High Very High
Dorsal horn 4 99.36 Very High Very High Very High
Nucleus accumbens 6 99.16 Very High Very High Very High
Neuropathic pain 4 99.08 Very High Very High Very High
Disease Link Frequency Relevance Heat
Convulsion 7 100.00 Very High Very High Very High
Depression 6 99.80 Very High Very High Very High
Neuropathic Pain 4 99.08 Very High Very High Very High
Pain 5 95.20 Very High Very High Very High
Cognitive Disorder 2 86.64 High High
Drug Dependence 11 72.28 Quite High
Wound Healing 1 56.40 Quite High
Death 4 55.36 Quite High
Injury 7 45.92 Quite Low
Disease 31 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The activation of the CB1 receptor leads to an induction of sleep, this effect is blocked via the selective antagonist.
Positive_regulation (induction) of Positive_regulation (activation) of CB1 associated with antagonist
1) Confidence 0.48 Published 2008 Journal Prog. Neuropsychopharmacol. Biol. Psychiatry Section Abstract Doc Link 18514375 Disease Relevance 0.10 Pain Relevance 0.60
In conclusion, CB1 and TRPV1 activation induces increases in HCEC proliferation and migration through EGFR transactivation leading to global MAPK and Akt/PI-3K pathway stimulation.
Positive_regulation (increases) of Positive_regulation (activation) of CB1 in HCEC associated with cannabinoid receptor
2) Confidence 0.45 Published 2010 Journal Exp. Eye Res. Section Abstract Doc Link 20619260 Disease Relevance 0.06 Pain Relevance 0.51
These data suggest that activation of cannabinoid CB1 receptor subtypes in GiA leads to behavioural analgesia.
Positive_regulation (leads) of Positive_regulation (activation) of CB1 receptor associated with cannabinoid and analgesia
3) Confidence 0.35 Published 2001 Journal Brain Res. Section Abstract Doc Link 11457432 Disease Relevance 0.16 Pain Relevance 0.87
CB1 receptor mediated analgesia from the Nucleus Reticularis Gigantocellularis pars alpha is activated in an animal model of neuropathic pain.
Positive_regulation (mediated) of Positive_regulation (activated) of CB1 receptor in Nucleus associated with analgesic, neuropathic pain and analgesia
4) Confidence 0.33 Published 2001 Journal Brain Res. Section Title Doc Link 11457432 Disease Relevance 0.17 Pain Relevance 0.90
In addition, the findings that eCBs release and CB1 receptor activation are necessary for LTD in both the nucleus accumbens [162, 163] and the dorsal neostriatum [67-69] support their involvement in those behaviours mediating the crucial transition from the reward-dependent form of drug-taking to the compulsive one.
Positive_regulation (necessary) of Positive_regulation (activation) of CB1 in dorsal associated with nucleus accumbens and depression
5) Confidence 0.27 Published 2007 Journal Current Neuropharmacology Section Body Doc Link PMC2644494 Disease Relevance 0.23 Pain Relevance 0.55
Moreover, inhibition of cannabinoid induced excitatory signaling by AM251 (100 pg/kg) unmasked a strong anticonvulsant effect for very low doses of ACEA (100 ng/kg-100 microg/kg), suggesting that a presumed inhibitory component of cannabinoid receptor signaling can exert strong seizure-protective effects even at very low levels of cannabinoid receptor activation.
Positive_regulation (exert) of Positive_regulation (activation) of cannabinoid receptor associated with convulsion, cannabinoid receptor, cannabinoid and anticonvulsant
6) Confidence 0.17 Published 2007 Journal Neuropharmacology Section Abstract Doc Link 17870135 Disease Relevance 0.47 Pain Relevance 1.17
On average, sequential use of SSR and tomography provide a 2.24-, 2.18-, and 3.01-fold improvement in CNR for HbO2, HbR, and HbT, respectively.


Positive_regulation (provide) of Positive_regulation (improvement) of CNR
7) Confidence 0.15 Published 2010 Journal Frontiers in Neuroenergetics Section Body Doc Link PMC2914577 Disease Relevance 0.09 Pain Relevance 0
Here, we show that chronic intrathecal treatment with morphine (10 microg, twice daily for 6 days) induced a time-dependent upregulation of both CB-1 and CB-2 receptors within the spinal cord dorsal horn.
Positive_regulation (induced) of Positive_regulation (induced) of CB-1 in spinal cord dorsal horn associated with dorsal horn, spinal cord, morphine and intrathecal
8) Confidence 0.11 Published 2005 Journal Brain Res. Section Abstract Doc Link 16150424 Disease Relevance 0 Pain Relevance 1.28
This morphine-induced CB-1 and CB-2 upregulation was dose-dependently attenuated by the intrathecal co-administration of morphine with the glucocorticoid receptor (GR) antagonist RU38486 (0.25, 0.5, or 2 microg).
Positive_regulation (induced) of Positive_regulation (upregulation) of CB-1 associated with antagonist, intrathecal and morphine
9) Confidence 0.10 Published 2005 Journal Brain Res. Section Abstract Doc Link 16150424 Disease Relevance 0 Pain Relevance 1.31

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