INT96971

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Context Info
Confidence 0.46
First Reported 2001
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 6
Total Number 6
Disease Relevance 2.27
Pain Relevance 1.67

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (Esr1) nucleus (Esr1) enzyme binding (Esr1)
DNA binding (Esr1) protein complex (Esr1) transcription factor binding (Esr1)
Anatomy Link Frequency
masseter 2
Esr1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Inflammation 31 98.76 Very High Very High Very High
Pain 3 98.76 Very High Very High Very High
Snapping jaw 47 98.56 Very High Very High Very High
allodynia 2 95.84 Very High Very High Very High
Trigeminal ganglion neurons 2 93.56 High High
agonist 23 89.48 High High
c fibre 1 88.72 High High
unmyelinated 1 88.36 High High
antagonist 44 86.40 High High
Calcium channel 16 85.96 High High
Disease Link Frequency Relevance Heat
Arthritis 52 99.84 Very High Very High Very High
INFLAMMATION 30 98.76 Very High Very High Very High
Pain 2 98.76 Very High Very High Very High
Temporomandibular Joint Syndrome 46 98.56 Very High Very High Very High
Neuropathic Pain 2 95.84 Very High Very High Very High
Ganglion Cysts 2 93.24 High High
Weight Loss 4 92.16 High High
Weight Gain 2 87.84 High High
Body Weight Changes 3 76.04 Quite High
Lordosis 1 74.48 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Moreover, progesterone could impact estrogen receptor expression and interact with 17 ?
Positive_regulation (impact) of Gene_expression (expression) of estrogen receptor
1) Confidence 0.46 Published 2009 Journal Reprod Biol Endocrinol Section Body Doc Link PMC2811708 Disease Relevance 0.42 Pain Relevance 0.39
Treatment with oestrogen increased expression of ERalpha but not GPR30, while masseter inflammation increased GRP30 but not ERalpha.
Positive_regulation (increased) of Gene_expression (expression) of ERalpha in masseter associated with inflammation
2) Confidence 0.36 Published 2009 Journal Cephalalgia Section Abstract Doc Link 19220308 Disease Relevance 0.50 Pain Relevance 0.80
Estrogen produced a dose-dependent increase in CAT activity in cotransfection assays with ERalpha expression vector and a 437PPE-CAT reporter construct containing 437 bp of the rat PPE gene promoter and the CAT reporter gene.
Positive_regulation (increase) of Gene_expression (expression) of ERalpha
3) Confidence 0.21 Published 2001 Journal Brain Res. Mol. Brain Res. Section Abstract Doc Link 11457489 Disease Relevance 0.07 Pain Relevance 0
There was a significant i) decrease in RBC count and haemoglobin, ii) increase in WBC count and ESR of arthritic rats, when compared with the control rats.
Positive_regulation (increase) of Gene_expression (count) of ESR associated with arthritis
4) Confidence 0.18 Published 2010 Journal BMC Complement Altern Med Section Body Doc Link PMC2978115 Disease Relevance 1.27 Pain Relevance 0.11
-E2 could be mediated through a subpopulation of the classical estrogen receptor (ER), ER?
Positive_regulation (subpopulation) of Gene_expression (classical) of estrogen receptor
5) Confidence 0.08 Published 2005 Journal Reprod Biol Endocrinol Section Body Doc Link PMC1201169 Disease Relevance 0 Pain Relevance 0.19
-E2 could be mediated through a subpopulation of the classical estrogen receptor (ER), ER?
Positive_regulation (-) of Gene_expression (classical) of estrogen receptor
6) Confidence 0.08 Published 2005 Journal Reprod Biol Endocrinol Section Body Doc Link PMC1201169 Disease Relevance 0 Pain Relevance 0.19

General Comments

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