INT96972

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Context Info
Confidence 0.22
First Reported 2001
Last Reported 2009
Negated 0
Speculated 1
Reported most in Body
Documents 4
Total Number 4
Disease Relevance 1.35
Pain Relevance 0.21

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (Esr1) nucleus (Esr1) enzyme binding (Esr1)
DNA binding (Esr1) protein complex (Esr1) transcription factor binding (Esr1)
Anatomy Link Frequency
thyroid 2
pituitary 2
Esr1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Bioavailability 2 97.68 Very High Very High Very High
Dismenorea 1 76.12 Quite High
cva 8 59.32 Quite High
Pain 5 52.64 Quite High
Enkephalin 1 25.00 Low Low
antagonist 5 5.00 Very Low Very Low Very Low
headache 2 5.00 Very Low Very Low Very Low
ketamine 1 5.00 Very Low Very Low Very Low
endometriosis 1 5.00 Very Low Very Low Very Low
backache 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Immunotherapy Of Cancer 5 95.92 Very High Very High Very High
Breast Cancer 60 90.28 High High
Body Weight 25 89.92 High High
Osteoporosis 7 84.40 Quite High
Cramps 1 79.36 Quite High
Weight Gain 8 76.80 Quite High
Reprotox - General 1 9 76.12 Quite High
Stroke 1 69.16 Quite High
Cataract 3 63.08 Quite High
Cv General 3 Under Development 6 59.32 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
These results suggest that estrogen regulation of the hypothalamic PPE gene expression is mediated through an estrogen-receptor complex directly interacting with the functional EREs in its promoter region; and that this estrogen effect can be modified by thyroid hormones.
Positive_regulation (mediated) of estrogen-receptor Binding (interacting) of in thyroid
1) Confidence 0.22 Published 2001 Journal Brain Res. Mol. Brain Res. Section Abstract Doc Link 11457489 Disease Relevance 0 Pain Relevance 0
Similar to ovariectomized animals, estrogen receptor binding was increased and arginase enzyme activity was decreased in tamoxifen-infused rats.
Positive_regulation (increased) of estrogen receptor Binding (binding) of
2) Confidence 0.15 Published 2006 Journal BMC Womens Health Section Abstract Doc Link PMC1590006 Disease Relevance 0.10 Pain Relevance 0.05
However, equol administration did increase an isoform of the estrogen receptor

(Terp-1) in the pituitary of these ovariectomized rats, and increased the

Positive_regulation (increase) of estrogen receptor Binding (isoform) of in pituitary
3) Confidence 0.12 Published 2009 Journal Journal of Toxicology Section Body Doc Link PMC2809433 Disease Relevance 0.17 Pain Relevance 0
This seemed to increase the estrogen receptor binding affinity and antiestrogenic properties, as well as improving oral bioavailability (Palkowitz et al. 1997; Suh et al. 2001).
Positive_regulation (increase) of estrogen receptor Spec (seemed) Binding (affinity) of associated with bioavailability
4) Confidence 0.06 Published 2007 Journal Core Evidence Section Body Doc Link PMC3012444 Disease Relevance 1.07 Pain Relevance 0.15

General Comments

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