INT96993

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Context Info
Confidence 0.59
First Reported 2001
Last Reported 2010
Negated 2
Speculated 3
Reported most in Body
Documents 15
Total Number 17
Disease Relevance 5.44
Pain Relevance 1.37

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

endosome (EGFR) cell morphogenesis (EGFR) Golgi apparatus (EGFR)
endoplasmic reticulum (EGFR) intracellular (EGFR) enzyme binding (EGFR)
EGFR (Homo sapiens)
Pain Link Frequency Relevance Heat
opioid receptor 13 99.98 Very High Very High Very High
Kinase C 17 97.28 Very High Very High Very High
antagonist 13 91.88 High High
qutenza 1 87.12 High High
chemokine 99 86.64 High High
COX2 10 83.60 Quite High
Opioid 1 79.68 Quite High
Inflammation 49 75.68 Quite High
cINOD 114 66.56 Quite High
Cannabinoid 18 64.56 Quite High
Disease Link Frequency Relevance Heat
Lung Cancer 229 98.20 Very High Very High Very High
Colon Cancer 88 97.32 Very High Very High Very High
Generaliased Trisomy 3 97.16 Very High Very High Very High
Breast Cancer 11 95.32 Very High Very High Very High
Neuroepithelial Neoplasms 9 94.44 High High
Prostate Cancer 22 92.32 High High
Acquired Immune Deficiency Syndrome Or Hiv Infection 21 91.56 High High
Disease 112 88.92 High High
Ovarian Cancer 91 88.24 High High
Cancer 326 85.68 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Interestingly, in Ist-Mes-2 cells, EGF stimulation induced EGFR phosphorylation as expected, but did not induce AKT and ERK phosphorylation, suggesting other possible signalling pathways of EGFR.


Neg (not) Positive_regulation (induced) of Phosphorylation (phosphorylation) of EGFR
1) Confidence 0.59 Published 2010 Journal Mol Cancer Section Body Doc Link PMC2828989 Disease Relevance 0.16 Pain Relevance 0.04
Additionally, it would be of interest to determine in cultured cells expressing high levels of CB1 receptors whether activation of these receptors results in an increased phosphorylation of EGFR, since this would provide an explanation for the low incidence of cases with a high CB1IR/low pEGFR-IR in the present study.

3.

Spec (whether) Positive_regulation (increased) of Phosphorylation (phosphorylation) of EGFR
2) Confidence 0.50 Published 2010 Journal PLoS ONE Section Body Doc Link PMC3009725 Disease Relevance 0.60 Pain Relevance 0.09
Only 2 patients displayed an increase in EGFR copy number that reached the definition of high polysomy (?
Positive_regulation (increase) of Phosphorylation (number) of EGFR
3) Confidence 0.50 Published 2008 Journal BMC Cancer Section Body Doc Link PMC2432064 Disease Relevance 0.42 Pain Relevance 0
METHODS: To investigate the effect of lidocaine (4 microM-40 mM) on epidermal growth factor (EGF)-stimulated autophosphorylation of EGFR, the authors studied purified EGFR in microtubes.
Spec (investigate) Positive_regulation (-stimulated) of Phosphorylation (autophosphorylation) of EGFR
4) Confidence 0.50 Published 2004 Journal Anesthesiology Section Body Doc Link 15114219 Disease Relevance 0 Pain Relevance 0
M sulindac sulfone markedly decreased the ability of EGF to induce phosphorylation of EGFR; total EGFR expression levels and ERK1/2 phosphorylation were also downregulated (Figure 4), albeit to a lesser extent than with sulindac sulfide.
Positive_regulation (induce) of Phosphorylation (phosphorylation) of EGFR
5) Confidence 0.49 Published 2005 Journal J Carcinog Section Body Doc Link PMC1208922 Disease Relevance 0.20 Pain Relevance 0
The effect of sulindac sulfone on EGF-induced phosphorylation of EGFR and ERK1/2 was also examined.
Positive_regulation (induced) of Spec (examined) Phosphorylation (phosphorylation) of EGFR
6) Confidence 0.49 Published 2005 Journal J Carcinog Section Body Doc Link PMC1208922 Disease Relevance 0.28 Pain Relevance 0
Impact of EGFR or EGFRvIII on Survival
Positive_regulation (on) of Phosphorylation (Impact) of EGFR
7) Confidence 0.49 Published 2005 Journal J Transl Med Section Body Doc Link PMC1298339 Disease Relevance 0.86 Pain Relevance 0
Pretreatment with sulindac metabolites for 24 h blocked EGF-induced phosphorylation of both EGFR and ERK1/2 and decreased total EGFR protein expression.
Positive_regulation (-) of Phosphorylation (phosphorylation) of EGFR
8) Confidence 0.46 Published 2005 Journal J Carcinog Section Abstract Doc Link PMC1208922 Disease Relevance 0.70 Pain Relevance 0.23
In Ist-Mes-1, Ist-Mes-2 and MPP89 cell lines, the addition of EGF at a concentration of 100 ng/mL significantly increased EGFR phosphorylation after 15 mins, when compared with the control.
Positive_regulation (increased) of Phosphorylation (phosphorylation) of EGFR
9) Confidence 0.42 Published 2010 Journal Mol Cancer Section Body Doc Link PMC2828989 Disease Relevance 0.15 Pain Relevance 0.04
However, exogenous EGF triggered further increases in EGFR and AKT phosphorylation in the Ist-Mes-1 and MPP89 cells that were reversed by gefitinib (Figure 3E).


Positive_regulation (increases) of Phosphorylation (phosphorylation) of EGFR
10) Confidence 0.42 Published 2010 Journal Mol Cancer Section Body Doc Link PMC2828989 Disease Relevance 0.15 Pain Relevance 0
Ist-Mes-1, Ist-Mes-2 and MPP89 were treated with EGF to increase the level of EGFR phosphorylation.
Positive_regulation (increase) of Phosphorylation (phosphorylation) of EGFR
11) Confidence 0.39 Published 2010 Journal Mol Cancer Section Body Doc Link PMC2828989 Disease Relevance 0.31 Pain Relevance 0
We demonstrated that EGFR phosphorylation was induced upon EGF treatment in over-expressing COX-2 MM cell lines and that, in these cell lines, EGFR inhibition with gefitinib and COX-2 inhibition with rofecoxib lead to decreases in proliferation.
Positive_regulation (induced) of Phosphorylation (phosphorylation) of EGFR associated with lung cancer
12) Confidence 0.39 Published 2010 Journal Mol Cancer Section Body Doc Link PMC2828989 Disease Relevance 0.25 Pain Relevance 0
For example, PS-ODNs can induce autophosphorylation of EGFR and thus, prevent the binding of EGF to its receptor [52].
Positive_regulation (induce) of Phosphorylation (autophosphorylation) of EGFR
13) Confidence 0.33 Published 2008 Journal Gene Regulation and Systems Biology Section Body Doc Link PMC2733095 Disease Relevance 0.17 Pain Relevance 0.10
Signal analyses showed that evodiamine stimulated the phosphorylation of EGFR, PKCalpha, and ERK, all of which were reduced by an EGFR inhibitor.
Positive_regulation (stimulated) of Phosphorylation (phosphorylation) of EGFR
14) Confidence 0.31 Published 2009 Journal FEBS Lett. Section Abstract Doc Link 19854188 Disease Relevance 0 Pain Relevance 0.18
A similar mechanism was also demonstrated in breast cancer cell lines, showing that estrogen-dependent proliferation involves the synthesis of CXCL12 (identified as estradiol-dependent gene), that causes an autocrine stimulation of CXCR4 and the subsequent activation of c-Src that, in turn, induces a ligand-independent activation of EGFR and ERK1/2 phosphorylation [41].
Positive_regulation (induces) of Phosphorylation (phosphorylation) of EGFR associated with breast cancer
15) Confidence 0.26 Published 2010 Journal Journal of Oncology Section Body Doc Link PMC2798669 Disease Relevance 0.86 Pain Relevance 0.22
EGFR phosphorylation was not changed in response to EGF or HB-EGF in Hsulf-1 expressing clones compared to controls (Figure 7 A).
Neg (not) Positive_regulation (changed) of Phosphorylation (phosphorylation) of EGFR
16) Confidence 0.17 Published 2005 Journal Mol Cancer Section Body Doc Link PMC1087876 Disease Relevance 0.32 Pain Relevance 0
Stimulation of MOR resulted in both epidermal growth factor receptor (EGFR) and ERK phosphorylation.
Positive_regulation (resulted) of Phosphorylation (phosphorylation) of epidermal growth factor receptor associated with opioid receptor
17) Confidence 0.12 Published 2001 Journal J. Biol. Chem. Section Abstract Doc Link 11457825 Disease Relevance 0 Pain Relevance 0.49

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