INT96994

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Context Info
Confidence 0.82
First Reported 2001
Last Reported 2010
Negated 0
Speculated 2
Reported most in Body
Documents 99
Total Number 103
Disease Relevance 52.75
Pain Relevance 7.33

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

endosome (EGFR) cell morphogenesis (EGFR) Golgi apparatus (EGFR)
endoplasmic reticulum (EGFR) intracellular (EGFR) enzyme binding (EGFR)
Anatomy Link Frequency
colon 3
apoptotic cell 2
blood vessel 2
Notch 1
OC 316 1
EGFR (Homo sapiens)
Pain Link Frequency Relevance Heat
opioid receptor 13 99.64 Very High Very High Very High
qutenza 3 99.40 Very High Very High Very High
lidocaine 36 99.10 Very High Very High Very High
agonist 45 98.62 Very High Very High Very High
Cannabinoid receptor 10 98.24 Very High Very High Very High
Kinase C 51 97.00 Very High Very High Very High
Inflammation 289 96.90 Very High Very High Very High
chemokine 499 96.68 Very High Very High Very High
cINOD 743 96.24 Very High Very High Very High
Cannabinoid 99 94.48 High High
Disease Link Frequency Relevance Heat
Lung Cancer 712 99.76 Very High Very High Very High
Cancer 4089 99.68 Very High Very High Very High
Prostate Cancer 343 99.40 Very High Very High Very High
Thyroid Neoplasm 89 99.32 Very High Very High Very High
Colon Cancer 752 99.20 Very High Very High Very High
Targeted Disruption 233 99.20 Very High Very High Very High
Exanthema 73 99.08 Very High Very High Very High
Ovarian Cancer 455 98.80 Very High Very High Very High
Breast Cancer 365 98.78 Very High Very High Very High
Apoptosis 1514 98.52 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Recent data have shown that it correlates with a decrease in EGFR phosphorylation, decreased invasion, lower nodal involvement, reduced subsequent metastasis, and longer disease-free and overall survival in stage II/III colorectal carcinoma patients who have received curative surgery[26].
Phosphorylation (phosphorylation) of EGFR associated with colon cancer, disease and metastasis
1) Confidence 0.82 Published 2008 Journal BMC Cancer Section Body Doc Link PMC2432064 Disease Relevance 1.02 Pain Relevance 0
We did not pursue this possibility further, since recent attempts in our laboratory to demonstrate in situ EGFR phosphorylation in lung tissue by immunohistochemical methods using phosphospecific antibodies were not successful [13].
Phosphorylation (phosphorylation) of EGFR in lung
2) Confidence 0.82 Published 2007 Journal Respir Res Section Body Doc Link PMC2214729 Disease Relevance 1.24 Pain Relevance 0.16
Histologically, the characteristic thinning of the stratum corneum and folliculitis induced by other EGFR inhibitors was not observed, whereas at the molecular level, nimotuzumab did not suppress EGFR phosphorylation, receptor signaling, or keratinocyte proliferation (Ki-67),56 echoing findings in a head and neck cancer trial.67 Nimotuzumab’s benign side-effect profile is not limited to the epidermis though, as it also includes the absence of severe hypomagnesemia and a lack of grade 3 or 4 gastrointestinal side effects, commonly seen in this class of agents.68,69
Phosphorylation (phosphorylation) of EGFR in head associated with hypomagnesemia, skin infection and head & neck cancer
3) Confidence 0.82 Published 2010 Journal Biologics : Targets & Therapy Section Body Doc Link PMC2990321 Disease Relevance 0.58 Pain Relevance 0
EGFR phosphorylation was significantly decreased in a dose-dependent manner for all eight mutants, with a minimum response at .002 ?
Phosphorylation (phosphorylation) of EGFR
4) Confidence 0.82 Published 2010 Journal World J Surg Oncol Section Body Doc Link PMC2970593 Disease Relevance 0.12 Pain Relevance 0
We investigated the effects of lidocaine (40-4000 microM) on proliferation of a human tongue cancer cell line, CAL27, which has a high level of EGFR expression, and also examined the effect of lidocaine on epidermal growth factor (EGF)-stimulated autophosphorylation of EGFR in CAL27 cells.
Phosphorylation (autophosphorylation) of EGFR in tongue associated with tongue neoplasms and lidocaine
5) Confidence 0.82 Published 2006 Journal Anesth. Analg. Section Abstract Doc Link 16551906 Disease Relevance 0.42 Pain Relevance 0.86
Only 2 patients displayed an increase in EGFR copy number that reached the definition of high polysomy (?
Phosphorylation (number) of EGFR
6) Confidence 0.81 Published 2008 Journal BMC Cancer Section Body Doc Link PMC2432064 Disease Relevance 0.42 Pain Relevance 0
METHODS: To investigate the effect of lidocaine (4 microM-40 mM) on epidermal growth factor (EGF)-stimulated autophosphorylation of EGFR, the authors studied purified EGFR in microtubes.
Phosphorylation (autophosphorylation) of EGFR
7) Confidence 0.81 Published 2004 Journal Anesthesiology Section Body Doc Link 15114219 Disease Relevance 0 Pain Relevance 0
They cultured human corneal epithelial cells (HCECs) with EGF and lidocaine to investigate the effect of lidocaine on cell proliferation and on autophosphorylation of EGFR in HCECs.
Phosphorylation (autophosphorylation) of EGFR in corneal epithelial cells
8) Confidence 0.81 Published 2004 Journal Anesthesiology Section Body Doc Link 15114219 Disease Relevance 0 Pain Relevance 0
In the HCEC study, EGF alone stimulated cell proliferation and increased autophosphorylation of EGFR in HCECs.
Phosphorylation (autophosphorylation) of EGFR
9) Confidence 0.81 Published 2004 Journal Anesthesiology Section Body Doc Link 15114219 Disease Relevance 0 Pain Relevance 0
RESULTS: Lidocaine (> or =400 microM) significantly suppressed EGF-stimulated autophosphorylation of the purified EGFR.
Phosphorylation (autophosphorylation) of EGFR
10) Confidence 0.81 Published 2004 Journal Anesthesiology Section Body Doc Link 15114219 Disease Relevance 0 Pain Relevance 0
Lidocaine (> or = 400 microM) significantly suppressed both the proliferation of HCECs promoted by EGF and EGF-stimulated autophosphorylation of EGFR.
Phosphorylation (autophosphorylation) of EGFR
11) Confidence 0.81 Published 2004 Journal Anesthesiology Section Body Doc Link 15114219 Disease Relevance 0 Pain Relevance 0
Experimental evidence is available showing that ROS may induce the ligand independent phosphorylation of the Epidermal Growth Factor Receptor (EGFR) through oxidized src kinases [12, 13].
Phosphorylation (phosphorylation) of EGFR
12) Confidence 0.81 Published 2010 Journal Journal of Nucleic Acids Section Body Doc Link PMC2911612 Disease Relevance 0.34 Pain Relevance 0
M sulindac sulfide blocked the ability of EGF to induce phosphorylation of EGFR in a dose dependent fashion.
Phosphorylation (phosphorylation) of EGFR
13) Confidence 0.81 Published 2005 Journal J Carcinog Section Body Doc Link PMC1208922 Disease Relevance 0.39 Pain Relevance 0
M sulindac sulfone markedly decreased the ability of EGF to induce phosphorylation of EGFR; total EGFR expression levels and ERK1/2 phosphorylation were also downregulated (Figure 4), albeit to a lesser extent than with sulindac sulfide.
Phosphorylation (phosphorylation) of EGFR
14) Confidence 0.81 Published 2005 Journal J Carcinog Section Body Doc Link PMC1208922 Disease Relevance 0.20 Pain Relevance 0
The effect of sulindac sulfone on EGF-induced phosphorylation of EGFR and ERK1/2 was also examined.
Spec (examined) Phosphorylation (phosphorylation) of EGFR
15) Confidence 0.81 Published 2005 Journal J Carcinog Section Body Doc Link PMC1208922 Disease Relevance 0.28 Pain Relevance 0
Small-molecule EGFR TK inhibitors (TKIs) are competetive inhibitors and bind reversibly to the intracellular catalytic domain of EGFR tyrosine kinase and, thus, inhibit EGFR autophosphorylation and downstream signaling.
Phosphorylation (autophosphorylation) of EGFR
16) Confidence 0.81 Published 2009 Journal OncoTargets and therapy Section Body Doc Link PMC2886327 Disease Relevance 0.34 Pain Relevance 0
M sulindac sulfone markedly decreased the ability of EGF to induce phosphorylation of EGFR; total EGFR expression levels and ERK1/2 phosphorylation were also downregulated (Figure 4), albeit to a lesser extent than with sulindac sulfide.
Phosphorylation (phosphorylation) of EGFR
17) Confidence 0.80 Published 2005 Journal J Carcinog Section Body Doc Link PMC1208922 Disease Relevance 0.20 Pain Relevance 0
After extensive washing the membranes were incubated with cocktail of biotin-conjugated anti-EGFR was used to detect phosphorylated EGFR on activated receptors.
Phosphorylation (phosphorylated) of EGFR
18) Confidence 0.80 Published 2009 Journal Mol Cancer Section Body Doc Link PMC2777152 Disease Relevance 0.32 Pain Relevance 0.04
Increased phosphorylation of ErbB2(Thr686), ErbB2(Ser1113) and limited phosphorylation of EGFR(Thy845), ErbB2(Tyr1221/1222), ErbB3(Tyr1289) and ErbB4(Tyr1284) sites was seen in the control group.
Phosphorylation (phosphorylation) of EGFR
19) Confidence 0.80 Published 2009 Journal Mol Cancer Section Body Doc Link PMC2777152 Disease Relevance 0.83 Pain Relevance 0
EGFR phosphorylation
Phosphorylation (phosphorylation) of EGFR
20) Confidence 0.80 Published 2009 Journal Mol Cancer Section Body Doc Link PMC2777152 Disease Relevance 1.07 Pain Relevance 0

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