INT97

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Context Info
Confidence 0.59
First Reported 1975
Last Reported 2009
Negated 3
Speculated 2
Reported most in Abstract
Documents 102
Total Number 104
Disease Relevance 32.44
Pain Relevance 26.90

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

aging (Adrb1) plasma membrane (Adrb1) nucleus (Adrb1)
cytoplasm (Adrb1) signal transducer activity (Adrb1)
Anatomy Link Frequency
heart 12
blood 6
sympathetic 4
spinal 3
head 3
Adrb1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
anesthesia 75 100.00 Very High Very High Very High
withdrawal 52 99.96 Very High Very High Very High
antagonist 37 99.96 Very High Very High Very High
opioid receptor 32 99.90 Very High Very High Very High
Hippocampus 7 99.84 Very High Very High Very High
cva 12 99.70 Very High Very High Very High
antidepressant 36 99.68 Very High Very High Very High
amygdala 13 99.68 Very High Very High Very High
halothane 12 99.68 Very High Very High Very High
Eae 1 99.68 Very High Very High Very High
Disease Link Frequency Relevance Heat
Heart Rate Under Development 100 99.92 Very High Very High Very High
Hypertension 59 99.86 Very High Very High Very High
Pressure And Volume Under Development 50 99.84 Very High Very High Very High
Pressure Volume 2 Under Development 19 99.76 Very High Very High Very High
Cv General 3 Under Development 39 99.70 Very High Very High Very High
Urological Neuroanatomy 17 99.60 Very High Very High Very High
Increased Venous Pressure Under Development 22 99.52 Very High Very High Very High
Occupational Lung Diseases 2 99.50 Very High Very High Very High
Coronary Artery Disease 66 99.42 Very High Very High Very High
Hemorrhagic Shock 5 99.36 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Chronic treatment of rats with a variety of antidepressants results in the down-regulation of beta-1-adrenoceptors in the amygdaloid nuclei.
Negative_regulation (down-regulation) of beta-1-adrenoceptors associated with antidepressant
1) Confidence 0.59 Published 1998 Journal Neuropsychopharmacology Section Abstract Doc Link 9718593 Disease Relevance 0 Pain Relevance 0.34
Rats treated chronically with either desipramine (DMI) or phenelzine (PHEN), which down-regulate beta-1-adrenoceptors in the amygdala, or fluoxetine (FLUOX), which does not do this, did not exhibit a deficit in the retention of the inhibitory avoidance task.
Negative_regulation (down-regulate) of beta-1-adrenoceptors in amygdala associated with desipramine, amygdala and fluoxetine
2) Confidence 0.59 Published 1998 Journal Neuropsychopharmacology Section Abstract Doc Link 9718593 Disease Relevance 0 Pain Relevance 0.45
These changes were not seen in patients with continued beta-receptor blockade.
Negative_regulation (blockade) of beta-receptor
3) Confidence 0.53 Published 1982 Journal Acta Anaesthesiol Scand Suppl Section Abstract Doc Link 6152884 Disease Relevance 0.44 Pain Relevance 0.27
These results suggest that patients on long-term beta-receptor blockade should continue the therapy during and after spinal anaesthesia.
Negative_regulation (blockade) of beta-receptor in spinal
4) Confidence 0.53 Published 1982 Journal Acta Anaesthesiol Scand Suppl Section Abstract Doc Link 6152884 Disease Relevance 0.39 Pain Relevance 0.25
Reduced lipolysis could be a result of diminished beta-receptor sensitivity in adipose tissue.
Negative_regulation (diminished) of beta-receptor in adipose tissue associated with obesity
5) Confidence 0.52 Published 2006 Journal Cephalalgia Section Abstract Doc Link 16776698 Disease Relevance 0.67 Pain Relevance 0.60
Careful selection of patients will reduce the frequency of adverse effects due to beta-receptor inhibition.
Negative_regulation (inhibition) of beta-receptor
6) Confidence 0.52 Published 1981 Journal Pharmacotherapy Section Abstract Doc Link 6765488 Disease Relevance 0.59 Pain Relevance 0.15
Although all patients were suffering from coronary artery and/or hypertensive heart disease with diminished cardiac reserve, no serious side effects were directly related to beta-receptor blockade.
Negative_regulation (blockade) of beta-receptor in heart associated with heart disease and hypertension
7) Confidence 0.52 Published 1979 Journal Wien. Klin. Wochenschr. Section Abstract Doc Link 88135 Disease Relevance 0.69 Pain Relevance 0.13
This effect was also observed after acute administration of these drugs, although they did not down-regulate amygdaloid beta-1-adrenoceptors at this time.
Neg (not) Negative_regulation (down-regulate) of beta-1-adrenoceptors
8) Confidence 0.51 Published 1998 Journal Neuropsychopharmacology Section Abstract Doc Link 9718593 Disease Relevance 0 Pain Relevance 0.50
It seems that the ability of these antidepressants to potentiate the amnesic effect of scopolamine is unrelated to their effect on beta-1-adrenoceptor number in the amygdala and that the extent of the antidepressant-induced amygdaloid beta-1-adrenoceptor down-regulation is not sufficient, by itself, to cause a deficit in an inhibitory avoidance task.
Negative_regulation (down-regulation) of beta-1-adrenoceptor in amygdala associated with antidepressant and amygdala
9) Confidence 0.51 Published 1998 Journal Neuropsychopharmacology Section Abstract Doc Link 9718593 Disease Relevance 0 Pain Relevance 0.46
Felodipine--a new vasodilator, in addition to beta-receptor blockade in hypertension.
Negative_regulation (blockade) of beta-receptor associated with pressure and volume under development
10) Confidence 0.49 Published 1983 Journal Eur. J. Clin. Pharmacol. Section Title Doc Link 6141051 Disease Relevance 0.52 Pain Relevance 0.14
The coronary hemodynamic and metabolic effects of nifedipine were evaluated after propranolol-induced acute beta-receptor blockade in 12 patients with angiographically documented coronary artery disease.
Negative_regulation (blockade) of beta-receptor in coronary artery associated with coronary artery disease
11) Confidence 0.49 Published 1985 Journal Am. J. Cardiol. Section Abstract Doc Link 3966396 Disease Relevance 0.17 Pain Relevance 0
The positive inotropic effect of calcium gluconate during halothane anesthesia was significantly reduced following either propranolol or practolol, but the hemodynamic responses to changes of systemic vascular resistance induced with acetylcholine or phenylephrine were not modified by beta-receptor blockade.
Negative_regulation (blockade) of beta-receptor associated with anesthesia and halothane
12) Confidence 0.49 Published 1976 Journal Anesthesiology Section Abstract Doc Link 9020 Disease Relevance 0.23 Pain Relevance 0.48
[An inverse reaction of the ST-T complex in the elctrocardiogram due to beta receptor inhibition].
Negative_regulation (inhibition) of beta receptor
13) Confidence 0.49 Published 1978 Journal Z Gesamte Inn Med Section Title Doc Link 28610 Disease Relevance 0.17 Pain Relevance 0.08
We found that down-regulation of beta-receptor in the myocardium appears after hemorrhagic shock of approximately 180 minutes and inversely, defense mechanism of the organism comes in by increasing its the affinity.
Negative_regulation (down-regulation) of beta-receptor in myocardium associated with hemorrhagic shock
14) Confidence 0.49 Published 1994 Journal Masui Section Abstract Doc Link 7915339 Disease Relevance 0.35 Pain Relevance 0.17
All patients were on chronic beta-receptor blockade because of hypertension and/or ischaemic heart disease.
Negative_regulation (blockade) of beta-receptor in heart associated with coronary artery disease and hypertension
15) Confidence 0.46 Published 1982 Journal Acta Anaesthesiol Scand Suppl Section Abstract Doc Link 6152884 Disease Relevance 0.37 Pain Relevance 0.18
Down-regulation of central beta-adrenergic receptors (beta-AR's) has been widely considered a common biochemical marker of antidepressant efficacy.
Negative_regulation (Down-regulation) of beta-AR associated with antidepressant
16) Confidence 0.43 Published 2004 Journal Life Sci. Section Abstract Doc Link 14672758 Disease Relevance 0.13 Pain Relevance 0.12
This effect was comparable to that of the lipophilic CO2 extract which decreased beta-AR-binding (13%) after two weeks and slightly increased the number of beta-AR's after 8 weeks (9%).
Negative_regulation (decreased) of beta-AR-binding
17) Confidence 0.43 Published 2004 Journal Life Sci. Section Abstract Doc Link 14672758 Disease Relevance 0.23 Pain Relevance 0.37
Short-term treatment with the methanolic SJW extract decreased beta-AR-binding (14%), no effects for this extract were observed after 8 weeks.
Negative_regulation (decreased) of beta-AR-binding
18) Confidence 0.43 Published 2004 Journal Life Sci. Section Abstract Doc Link 14672758 Disease Relevance 0.24 Pain Relevance 0.32
Treatment with hypericin led to a significant down-regulation (13%) of beta-AR's in the frontal cortex after 8-weeks, but not after 2 weeks, while hyperforin (used as trimethoxybenzoate, TMB), and hyperoside were ineffective in both treatment paradigms.
Negative_regulation (down-regulation) of beta-AR in frontal cortex associated with urological neuroanatomy
19) Confidence 0.43 Published 2004 Journal Life Sci. Section Abstract Doc Link 14672758 Disease Relevance 0.24 Pain Relevance 0.27
Although previous studies have reported a beta-AR down-regulation for SJW extracts, in vivo studies that compare the effects of SJW extracts with those of relevant active constituents on beta-AR density have not been done yet.
Negative_regulation (down-regulation) of beta-AR
20) Confidence 0.43 Published 2004 Journal Life Sci. Section Abstract Doc Link 14672758 Disease Relevance 0.14 Pain Relevance 0.19

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