INT97017

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Context Info
Confidence 0.40
First Reported 2001
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 3
Disease Relevance 0
Pain Relevance 1.06

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleoplasm (CALM3) small molecule metabolic process (CALM3) carbohydrate metabolic process (CALM3)
cytoplasm (CALM3) cytosol (CALM3) signal transduction (CALM3)
Anatomy Link Frequency
lobe 2
CALM3 (Homo sapiens)
Pain Link Frequency Relevance Heat
mu opioid receptor 14 99.60 Very High Very High Very High
Analgesic 1 93.12 High High
Morphine 3 92.00 High High
TRP channel 8 86.96 High High
adenocard 2 85.20 High High
addiction 5 70.32 Quite High
tolerance 1 69.72 Quite High
Opioid 1 69.32 Quite High
agonist 7 66.56 Quite High
qutenza 2 5.00 Very Low Very Low Very Low

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Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In conclusion, each of the three single nucleotide polymorphisms mapping to the i3 loop of MOR caused substantial changes in basal G protein coupling, CaM binding, or both.
Regulation (changes) of CaM Binding (binding) of associated with mu opioid receptor
1) Confidence 0.40 Published 2001 Journal J. Biol. Chem. Section Abstract Doc Link 11457836 Disease Relevance 0 Pain Relevance 0.90
In contrast to these findings, TRPV4 neither binds to CaM in Ca2+-free buffers, nor to CaM1234, and potentiation of its activity directly depends on CaM interaction triggered by a rise in Ca2+.
Regulation (depends) of CaM Binding (interaction) of
2) Confidence 0.19 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2867956 Disease Relevance 0 Pain Relevance 0.08
This suggests that, in spite of its lower affinity to the C-terminal CaM binding site in TRPV4, the CaM N lobe contributes functionally to TRPV4 potentiation by a mechanism which remains unclear.
Regulation (contributes) of CaM Binding (affinity) of in lobe
3) Confidence 0.12 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2867956 Disease Relevance 0 Pain Relevance 0.08

General Comments

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