INT97026

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Context Info
Confidence 0.16
First Reported 2001
Last Reported 2007
Negated 0
Speculated 0
Reported most in Title
Documents 2
Total Number 2
Disease Relevance 0.74
Pain Relevance 0.61

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (ASIC2)
Anatomy Link Frequency
hippocampus 1
ASIC2 (Homo sapiens)
Pain Link Frequency Relevance Heat
Hippocampus 8 99.32 Very High Very High Very High
addiction 1 87.08 High High
tissue acidosis 1 68.24 Quite High
Pain 1 66.52 Quite High
Gabapentin 1 65.68 Quite High
Lamotrigine 1 65.20 Quite High
ASIC 1 60.76 Quite High
carbamazepine 1 58.56 Quite High
Disease Link Frequency Relevance Heat
Convulsion 5 98.72 Very High Very High Very High
Epilepsy 4 96.96 Very High Very High Very High
Acidosis 1 68.24 Quite High
Pain 1 66.52 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Mutation of another histidine residue, His-72, abolishes the pH sensitivity of ASIC2a.
Regulation (sensitivity) of ASIC2a
1) Confidence 0.16 Published 2001 Journal J. Biol. Chem. Section Abstract Doc Link 11457851 Disease Relevance 0.13 Pain Relevance 0.21
Up-regulated astroglial TWIK-related acid-sensitive K+ channel-1 (TASK-1) in the hippocampus of seizure-sensitive gerbils: a target of anti-epileptic drugs.
Regulation (regulated) of channel-1 in hippocampus associated with epilepsy, convulsion and hippocampus
2) Confidence 0.00 Published 2007 Journal Brain Res. Section Title Doc Link 17959156 Disease Relevance 0.61 Pain Relevance 0.40

General Comments

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