INT97032

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Context Info
Confidence 0.52
First Reported 2001
Last Reported 2006
Negated 0
Speculated 0
Reported most in Abstract
Documents 3
Total Number 3
Disease Relevance 0.58
Pain Relevance 1.04

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleus (Snai1) cytoplasm (Snai1)
Anatomy Link Frequency
RVLM 1
neurons 1
heart 1
Snai1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Rostral ventrolateral medulla 16 99.50 Very High Very High Very High
Intracerebroventricular 4 95.80 Very High Very High Very High
opioid receptor 1 82.12 Quite High
Opioid 1 80.80 Quite High
antagonist 1 80.24 Quite High
narcan 1 79.36 Quite High
anesthesia 2 69.68 Quite High
Clonidine 1 68.08 Quite High
Raphe 1 64.64 Quite High
Spinal cord 1 54.56 Quite High
Disease Link Frequency Relevance Heat
Obesity 12 99.14 Very High Very High Very High
Fever 2 75.00 Quite High
Pressure Volume 2 Under Development 1 74.80 Quite High
Suicidal Behaviour 1 49.28 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Both of these nuclei project to the rostral ventrolateral medulla (RVLM), critical in the tonic generation of SNA.
Gene_expression (generation) of SNA in RVLM associated with rostral ventrolateral medulla
1) Confidence 0.52 Published 2006 Journal Am. J. Physiol. Regul. Integr. Comp. Physiol. Section Abstract Doc Link 16682470 Disease Relevance 0 Pain Relevance 0.27
Increases in brown adipose tissue (BAT) sympathetic nerve activity (SNA) (peak, +326% of control), BAT temperature (peak, +0.8 degrees C), renal SNA (peak, +146% of control), and heart rate (HR; peak, +32 beats/min) produced by intravenous fentanyl were abolished by premamillary transection of the neuraxis but were mimicked by intracerebroventricular administration of fentanyl, which also increased arterial pressure (AP; peak, +12 mmHg).
Gene_expression (produced) of SNA in heart associated with obesity and intracerebroventricular
2) Confidence 0.46 Published 2005 Journal Am. J. Physiol. Regul. Integr. Comp. Physiol. Section Abstract Doc Link 15576661 Disease Relevance 0.50 Pain Relevance 0.35
In summary, the integrity of C1 neurons is not essential for the generation of SNA and the maintenance of BP under resting conditions, perhaps because these functions are performed primarily by noncatecholaminergic BS neurons.
Gene_expression (generation) of SNA in neurons
3) Confidence 0.43 Published 2001 Journal Ann. N. Y. Acad. Sci. Section Abstract Doc Link 11458683 Disease Relevance 0.07 Pain Relevance 0.42

General Comments

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