INT9704

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Context Info
Confidence 0.49
First Reported 1987
Last Reported 2005
Negated 0
Speculated 1
Reported most in Abstract
Documents 8
Total Number 9
Disease Relevance 1.75
Pain Relevance 15.40

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Link Frequency
Spinal 2
RVM 2
EM-2 2
VLPT 2
heart 2
tf (Mus musculus)
Pain Link Frequency Relevance Heat
Morphine 84 100.00 Very High Very High Very High
tail-flick 54 100.00 Very High Very High Very High
Opioid 21 99.98 Very High Very High Very High
Rostral ventromedial medulla 15 99.72 Very High Very High Very High
amygdala 9 99.48 Very High Very High Very High
medulla 8 99.10 Very High Very High Very High
intrathecal 12 98.44 Very High Very High Very High
Enkephalin 20 97.68 Very High Very High Very High
lidocaine 11 97.44 Very High Very High Very High
narcan 12 96.96 Very High Very High Very High
Disease Link Frequency Relevance Heat
Heart Rate Under Development 6 98.36 Very High Very High Very High
Urological Neuroanatomy 15 96.08 Very High Very High Very High
Nociception 10 79.76 Quite High
Depression 1 66.08 Quite High
Pressure Volume 2 Under Development 2 55.04 Quite High
Pain 1 52.88 Quite High
Stress 1 51.92 Quite High
Hypoalagesia 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Intrathecal pretreatment with EM-2 (0.02-1.75 nmol) 45 min before i.t. morphine (3.0 nmol) injection dose dependently attenuated morphine-induced TF inhibition.
Negative_regulation (attenuated) of Negative_regulation (inhibition) of TF in EM-2 associated with tail-flick, morphine and intrathecal
1) Confidence 0.49 Published 2003 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 14557378 Disease Relevance 0 Pain Relevance 1.69
Intrathecal pretreatment with dextro-morphine (0.3-33 fmol), which injected alone did not affect the baseline TF latency, dose-dependently attenuated the TF inhibition produced by i.t.
Negative_regulation (attenuated) of Negative_regulation (inhibition) of TF associated with tail-flick, morphine and intrathecal
2) Confidence 0.40 Published 2005 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 15901793 Disease Relevance 0 Pain Relevance 2.05
Intrathecal pretreatment with morphine (0.009-0.3 nmol) for 45 min also dose dependently attenuated morphine-produced TF inhibition.
Negative_regulation (attenuated) of Negative_regulation (inhibition) of TF associated with tail-flick, morphine and intrathecal
3) Confidence 0.40 Published 2004 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 14999057 Disease Relevance 0 Pain Relevance 1.84
The i.t. morphine pretreatment also attenuated the TF inhibition produced by opioid muagonist [D-Ala2, N-Me-Phe4,Gly-ol5]-enkephalin, delta-agonist deltorphin II, and kappa-agonist U50,488H.
Negative_regulation (attenuated) of Negative_regulation (inhibition) of TF associated with agonist, tail-flick, enkephalin, opioid and morphine
4) Confidence 0.29 Published 2004 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 14999057 Disease Relevance 0 Pain Relevance 2.76
Opioid inhibition of the TF was also reduced, although baseline TF latency was unaffected, by RVM kynurenate.
Negative_regulation (reduced) of Negative_regulation (inhibition) of TF in RVM associated with opioid and rostral ventromedial medulla
5) Confidence 0.19 Published 1999 Journal Pain Section Abstract Doc Link 10353493 Disease Relevance 0.19 Pain Relevance 1.62
Chronic RVM lesions also blocked TF inhibition produced by amygdala stimulation but did not affect heart rate.
Negative_regulation (blocked) of Negative_regulation (inhibition) of TF in heart associated with tail-flick, amygdala and rostral ventromedial medulla
6) Confidence 0.05 Published 1998 Journal Brain Res. Section Abstract Doc Link 9473612 Disease Relevance 0.40 Pain Relevance 2.08
Microinjection of either lidocaine or ibotenic acid into the nuclei tracti solitarii (NTS), rostromedial medulla (RMM), or ventrolateral pontine tegmentum (VLPT) attenuated morphine-induced inhibition of the TF reflex.
Negative_regulation (attenuated) of Negative_regulation (inhibition) of TF in VLPT associated with medulla, tail-flick, lidocaine and morphine
7) Confidence 0.05 Published 1992 Journal J. Neurophysiol. Section Abstract Doc Link 1432065 Disease Relevance 0.42 Pain Relevance 1.57
Pentobarbital produced a clear inhibition of the TF response.
Negative_regulation (produced) of Spec (clear) Negative_regulation (inhibition) of TF associated with tail-flick
8) Confidence 0.04 Published 1987 Journal Brain Res. Section Abstract Doc Link 3032363 Disease Relevance 0.21 Pain Relevance 0.45
Spinal cold block significantly attenuated inhibition of the TF reflex, the depressor response, and the bradycardia produced by intravenous administration of morphine.
Negative_regulation (attenuated) of Negative_regulation (inhibition) of TF in Spinal associated with heart rate under development, tail-flick and morphine
9) Confidence 0.04 Published 1992 Journal J. Neurophysiol. Section Abstract Doc Link 1432065 Disease Relevance 0.53 Pain Relevance 1.33

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