INT97052

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Context Info
Confidence 0.64
First Reported 2001
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 12
Total Number 12
Disease Relevance 6.52
Pain Relevance 1.01

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleoplasm (Trp53) mitochondrion (Trp53) endoplasmic reticulum (Trp53)
enzyme binding (Trp53) protein complex assembly (Trp53) DNA binding (Trp53)
Anatomy Link Frequency
brain 1
Trp53 (Mus musculus)
Pain Link Frequency Relevance Heat
Paracetamol 16 99.22 Very High Very High Very High
antagonist 1 75.00 Quite High
interstitial cystitis 2 66.84 Quite High
fibrosis 6 46.40 Quite Low
Analgesic 2 30.28 Quite Low
Potency 5 26.84 Quite Low
Pain 5 5.00 Very Low Very Low Very Low
cINOD 4 5.00 Very Low Very Low Very Low
ischemia 4 5.00 Very Low Very Low Very Low
Hippocampus 4 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Cancer 63 99.76 Very High Very High Very High
Small Cell Lung Cancer 7 99.50 Very High Very High Very High
Metastasis 3 99.34 Very High Very High Very High
Huntington's Chorea 4 98.52 Very High Very High Very High
Injury 15 95.52 Very High Very High Very High
Targeted Disruption 152 92.72 High High
Apoptosis 370 91.04 High High
Hepatotoxicity 3 86.40 High High
Stress 44 80.40 Quite High
Death 40 75.00 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The lower levels of p53 protein were sufficient to affect p53 mediated transcription.
Transcription (transcription) of p53
1) Confidence 0.64 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2944824 Disease Relevance 0.82 Pain Relevance 0
Another possibility is that Hr represses transcription of p53 through a mechanism involving HDAC1and a nuclear receptor.
Transcription (transcription) of p53
2) Confidence 0.64 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2944824 Disease Relevance 0.50 Pain Relevance 0
A decrease in p53 dependent transcription, and in levels of Bax, which is regulated by p53 [30], was observed in COS cells expressing Hr.
Transcription (transcription) of p53
3) Confidence 0.64 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2944824 Disease Relevance 1.15 Pain Relevance 0
The effect of AAP on bcl-XL was antagonized and that on p53 was synergized by the PARP-modulator 4-AB as well as NICO, whereas the endonuclease inhibitor CPZ was without effect on either bcl-XL or p53 expression.
Transcription (synergized) of p53 associated with paracetamol
4) Confidence 0.63 Published 2001 Journal Free Radic. Biol. Med. Section Abstract Doc Link 11461765 Disease Relevance 0.60 Pain Relevance 0.87
The lower levels of p53 protein were sufficient to affect p53 mediated transcription.
Transcription (transcription) of p53
5) Confidence 0.62 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2944824 Disease Relevance 0.84 Pain Relevance 0
According to the ATCC, the H526 cell line, initiated using a bone metastasis of SCLC prior to therapy, shows expression of neuron-specific enolase, brain enzyme of creatine kinase, and p53 mRNA.
Transcription (expression) of p53 in brain associated with small cell lung cancer and metastasis
6) Confidence 0.52 Published 2009 Journal Metal-Based Drugs Section Body Doc Link PMC2705772 Disease Relevance 0.35 Pain Relevance 0
Gene recombination was also observed when the UPII-Cre line was crossed to an independent line in which a part of the p53 gene was flanked by the loxP sequences (floxed p53).
Transcription (flanked) of p53
7) Confidence 0.45 Published 2005 Journal Am. J. Physiol. Renal Physiol. Section Abstract Doc Link 15840768 Disease Relevance 0.75 Pain Relevance 0.07
Gene recombination was also observed when the UPII-Cre line was crossed to an independent line in which a part of the p53 gene was flanked by the loxP sequences (floxed p53).
Transcription (flanked) of p53
8) Confidence 0.39 Published 2005 Journal Am. J. Physiol. Renal Physiol. Section Abstract Doc Link 15840768 Disease Relevance 0.75 Pain Relevance 0.07
These differences in p21 protein and BrdU index were predicted based on p53 status of these two cell lines and are in parallel with other reports on mammary tumors, where the absence of p53 results primarily in greater proliferation response in the affected cell [42].
Neg (absence) Transcription (absence) of p53 associated with cancer
9) Confidence 0.34 Published 2001 Journal Breast Cancer Res Section Body Doc Link PMC13923 Disease Relevance 0.10 Pain Relevance 0
The endogenous mRNA expression of Oct3/4, Sox2, Klf4, c-Myc, p53, p21 and Tert in pGFs, mGFs and TTFs at passages 4 to 6 was determined by real-time RT-PCR analysis.
Transcription (expression) of p53
10) Confidence 0.12 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2939066 Disease Relevance 0 Pain Relevance 0
Most previous studies indicated that HDAC inhibitors upregulate the transcription of p53 [31,32].
Transcription (transcription) of p53
11) Confidence 0.11 Published 2010 Journal J Exp Clin Cancer Res Section Body Doc Link PMC2994814 Disease Relevance 0.66 Pain Relevance 0
In addition to NRs, NIF-1 enhances the transcriptional activity of c-Fos, c-Jun and p53 [Mahajan et al., 2007; Mahajan et al., 2002].
Transcription (activity) of p53
12) Confidence 0.08 Published 2008 Journal Nuclear Receptor Signaling Section Body Doc Link PMC2254332 Disease Relevance 0 Pain Relevance 0

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