INT97055

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.70
First Reported 2001
Last Reported 2011
Negated 0
Speculated 2
Reported most in Body
Documents 51
Total Number 54
Disease Relevance 45.70
Pain Relevance 7.25

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleoplasm (Trp53) mitochondrion (Trp53) endoplasmic reticulum (Trp53)
enzyme binding (Trp53) protein complex assembly (Trp53) DNA binding (Trp53)
Anatomy Link Frequency
spinal cord 6
fibroblast 6
colon 4
lymph node 2
livers 2
Trp53 (Mus musculus)
Pain Link Frequency Relevance Heat
Spinal cord 6 100.00 Very High Very High Very High
Paracetamol 30 99.84 Very High Very High Very High
Morphine 24 98.64 Very High Very High Very High
Somatostatin 71 98.38 Very High Very High Very High
Bile 60 97.96 Very High Very High Very High
Osteoarthritis 37 96.88 Very High Very High Very High
Antinociceptive 12 96.20 Very High Very High Very High
tolerance 31 95.56 Very High Very High Very High
rheumatoid arthritis 79 89.64 High High
Chronic pancreatitis 4 88.60 High High
Disease Link Frequency Relevance Heat
Viral Infection 7 100.00 Very High Very High Very High
Repression 6 100.00 Very High Very High Very High
Cancer 1967 99.92 Very High Very High Very High
Glioma 234 99.84 Very High Very High Very High
Pancreatic Cancer 65 99.84 Very High Very High Very High
Carcinoma 183 99.72 Very High Very High Very High
Colon Cancer 40 99.46 Very High Very High Very High
Aging 74 99.44 Very High Very High Very High
Stress 126 99.38 Very High Very High Very High
Apoptosis 856 99.08 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Apoptosis is however not frequently seen upon retroviral expression or activation of endogenous p53 in glioma cell lines [36], but overexpression of p53 by adenovirus may sensitize glioma cells to apoptosis [155].
Positive_regulation (overexpression) of Gene_expression (overexpression) of p53 associated with apoptosis and glioma
1) Confidence 0.70 Published 2011 Journal Journal of Oncology Section Body Doc Link PMC3010739 Disease Relevance 1.71 Pain Relevance 0
Numerous studies have also been carried out in order to investigate the effects of p53 overexpression in glioma cells.
Spec (investigate) Positive_regulation (overexpression) of Spec (investigate) Gene_expression (overexpression) of p53 associated with glioma
2) Confidence 0.70 Published 2011 Journal Journal of Oncology Section Body Doc Link PMC3010739 Disease Relevance 1.09 Pain Relevance 0
Moreover, p53 expression in the spinal cord had increased significantly 14h after the last morphine administration.
Positive_regulation (increased) of Gene_expression (expression) of p53 in spinal cord associated with morphine and spinal cord
3) Confidence 0.69 Published 2009 Journal Neurosci. Lett. Section Abstract Doc Link 19084050 Disease Relevance 0.14 Pain Relevance 1.12
These results indicate that the increased expression and activation of p53, and the nitric oxide and caspase systems related to p53 may contribute to the development of antinociceptive tolerance to morphine in the mouse spinal cord.
Positive_regulation (increased) of Gene_expression (expression) of p53 in spinal cord associated with tolerance, antinociceptive, spinal cord and morphine
4) Confidence 0.69 Published 2009 Journal Neurosci. Lett. Section Abstract Doc Link 19084050 Disease Relevance 0.13 Pain Relevance 1.11
Compared to control, there was a considerable decrease in bcl-XL expression, and an increase in p53 expression in AAP-exposed livers.
Positive_regulation (increase) of Gene_expression (expression) of p53 in livers associated with paracetamol
5) Confidence 0.64 Published 2001 Journal Free Radic. Biol. Med. Section Abstract Doc Link 11461765 Disease Relevance 0.59 Pain Relevance 0.82
Increased expression of p53 shifts the balance of gene expression in favor of pro-apoptotic family members in cells undergoing apoptosis.
Positive_regulation (Increased) of Gene_expression (expression) of p53 associated with apoptosis
6) Confidence 0.62 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2944824 Disease Relevance 1.32 Pain Relevance 0
As expected, the expression of p53 protein increased in mock Hr transfected COS cells treated with either tunicamycin or staurosporine (figure 4).
Positive_regulation (increased) of Gene_expression (expression) of p53
7) Confidence 0.62 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2944824 Disease Relevance 1.01 Pain Relevance 0
However, there was no difference in p53 overexpression according to anatomic site, and prognostic roles were not identified for cyclin D1 and p53 [11].
Positive_regulation (overexpression) of Gene_expression (overexpression) of p53
8) Confidence 0.53 Published 2010 Journal BMC Cancer Section Body Doc Link PMC2974735 Disease Relevance 1.40 Pain Relevance 0.04
While approximately half of all human tumors contain a mutation or deletion of TP53, the rest of the tumors often have inactivation of p53 through other mechanisms including viral infection, loss of ARF, or overexpression of MDM2 [21].
Positive_regulation (inactivation) of Gene_expression (overexpression) of p53 associated with cancer and viral infection
9) Confidence 0.50 Published 2011 Journal Journal of Oncology Section Body Doc Link PMC3010739 Disease Relevance 1.43 Pain Relevance 0
While approximately half of all human tumors contain a mutation or deletion of TP53, the rest of the tumors often have inactivation of p53 through other mechanisms including viral infection, loss of ARF, or overexpression of MDM2 [21].
Positive_regulation (overexpression) of Gene_expression (overexpression) of p53 associated with cancer and viral infection
10) Confidence 0.50 Published 2011 Journal Journal of Oncology Section Body Doc Link PMC3010739 Disease Relevance 1.42 Pain Relevance 0
These results indicate that the increased expression and activation of p53, and the nitric oxide and caspase systems related to p53 may contribute to the development of antinociceptive tolerance to morphine in the mouse spinal cord.
Positive_regulation (increased) of Gene_expression (expression) of p53 in spinal cord associated with tolerance, antinociceptive, spinal cord and morphine
11) Confidence 0.50 Published 2009 Journal Neurosci. Lett. Section Abstract Doc Link 19084050 Disease Relevance 0.13 Pain Relevance 1.11
p53 protein was found to be overexpressed mainly in the nucleus in four of eleven cases (36%) (Figure 1D).
Positive_regulation (overexpressed) of Gene_expression (overexpressed) of p53 in nucleus
12) Confidence 0.50 Published 2004 Journal BMC Urol Section Body Doc Link PMC517938 Disease Relevance 0.76 Pain Relevance 0
Although an association between p53 protein overexpression and tumor stage, grade and survival has been observed in RCC [30] our data suggest that involvement of p53 alterations does not occur with the same frequency in CDC.
Positive_regulation (overexpression) of Gene_expression (overexpression) of p53 associated with cancer, carcinoma and renal cell carcinoma
13) Confidence 0.50 Published 2004 Journal BMC Urol Section Body Doc Link PMC517938 Disease Relevance 1.07 Pain Relevance 0
Activation of endogenous wild-type p53 with small molecules, reactivation of mutant p53, or transfer of the p53 gene should therefore be considered [152].
Positive_regulation (transfer) of Gene_expression (transfer) of p53
14) Confidence 0.47 Published 2011 Journal Journal of Oncology Section Body Doc Link PMC3010739 Disease Relevance 1.06 Pain Relevance 0
This study investigated the effect of AAP on the expression of these oncogenes and whether agents that modulate DNA fragmentation (chlorpromazine, CPZ) and DNA repair through poly(ADP-Ribose) polymerase (PARP) activity (4-AB: 4-aminobenzamide) can protect against AAP-induced hepatotoxicity by inhibiting oxidative stress, DNA fragmentation, and/or by altering the expression of bcl-XL and p53.
Positive_regulation (altering) of Gene_expression (expression) of p53 in poly associated with stress, paracetamol and hepatotoxicity
15) Confidence 0.46 Published 2001 Journal Free Radic. Biol. Med. Section Abstract Doc Link 11461765 Disease Relevance 0.67 Pain Relevance 0.73
To determine whether the effects of Hr are mediated through decreased expression and activity of p53, the effects of Hr on apoptosis were examined in mouse embryonic fibroblast (MEF) cell lines derived from p53 knock out and wild-type mice.
Spec (whether) Positive_regulation (mediated) of Gene_expression (expression) of p53 in MEF associated with targeted disruption and apoptosis
16) Confidence 0.42 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2944824 Disease Relevance 0.75 Pain Relevance 0
The lower levels of p53 protein were sufficient to affect p53 mediated transcription.
Positive_regulation (sufficient) of Gene_expression (levels) of p53
17) Confidence 0.42 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2944824 Disease Relevance 0.79 Pain Relevance 0
However, recent studies disclosed genetic differences regarding p53 protein overexpression among carcinomas of the proximal (ICC) and distal bile ducts (BDC), indicating different patterns of the inactivation of tumour-suppressor genes [1].
Positive_regulation (overexpression) of Gene_expression (overexpression) of p53 in proximal associated with bile, cholangiocarcinoma, cancer and carcinoma
18) Confidence 0.41 Published 2006 Journal Virchows Arch Section Body Doc Link PMC1888720 Disease Relevance 1.26 Pain Relevance 0.13
The expression of p53 protein was greatly enhanced in AdSiCIAPIN1-infected HepG2 and SMMC-7721 cells (supplementary Figure A is available at Carcinogenesis Online).
Positive_regulation (enhanced) of Gene_expression (expression) of p53
19) Confidence 0.40 Published 2008 Journal Carcinogenesis Section Body Doc Link PMC2516489 Disease Relevance 0.93 Pain Relevance 0
Irradiation induced the expression of P53 and P21 proteins in endothelial cells, but p53 or p21 deficiency and P21 silencing did not prevent radiation-induced inhibition of sprouting or proliferation.
Positive_regulation (induced) of Gene_expression (expression) of P53 in endothelial cells
20) Confidence 0.38 Published 2010 Journal PLoS ONE Section Abstract Doc Link PMC2884035 Disease Relevance 0.41 Pain Relevance 0

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox