INT97062

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Context Info
Confidence 0.41
First Reported 2001
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 10
Total Number 10
Disease Relevance 11.63
Pain Relevance 1.65

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

endosome (PML) nucleoplasm (PML) endoplasmic reticulum (PML)
intracellular (PML) protein complex assembly (PML) DNA binding (PML)
Anatomy Link Frequency
cerebrospinal fluid 1
immune system 1
Head 1
PML (Homo sapiens)
Pain Link Frequency Relevance Heat
Multiple sclerosis 320 99.04 Very High Very High Very High
imagery 106 97.04 Very High Very High Very High
headache 15 92.36 High High
Inflammation 46 91.20 High High
corticosteroid 11 89.08 High High
rheumatoid arthritis 2 88.32 High High
Infliximab 7 81.56 Quite High
Demyelination 14 73.32 Quite High
cytokine 11 59.28 Quite High
Central nervous system 40 56.64 Quite High
Disease Link Frequency Relevance Heat
Progressive Multifocal Leukoencephalopathy 167 100.00 Very High Very High Very High
Acquired Immune Deficiency Syndrome Or Hiv Infection 19 100.00 Very High Very High Very High
Tremor 4 99.98 Very High Very High Very High
Encephalomalacia 1 99.92 Very High Very High Very High
Organ Transplantation 4 99.84 Very High Very High Very High
Demyelinating Disease 361 99.56 Very High Very High Very High
Opportunistic Infections 11 99.24 Very High Very High Very High
Neurological Disease 1 99.00 Very High Very High Very High
Ataxia 5 98.64 Very High Very High Very High
Myoclonus 1 97.80 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Head tremor associated with PML has not been previously reported.
PML Binding (associated) of in Head associated with tremor and progressive multifocal leukoencephalopathy
1) Confidence 0.41 Published 2005 Journal Arq Neuropsiquiatr Section Abstract Doc Link 15830082 Disease Relevance 1.45 Pain Relevance 0.09
PML in AIDS patients has been associated with a nearly uniformly poor prognosis until recent reports of improved outcomes after highly active antiretroviral therapy.
PML Binding (associated) of associated with progressive multifocal leukoencephalopathy and acquired immune deficiency syndrome or hiv infection
2) Confidence 0.29 Published 2001 Journal J Neuroimaging Section Abstract Doc Link 11462308 Disease Relevance 1.37 Pain Relevance 0.38
At this time, the treating neurologist suspected PML and a cerebrospinal fluid (CSF) sample was sent out for JC virus PCR testing, which returned positive.
PML Binding (sent) of in cerebrospinal fluid associated with progressive multifocal leukoencephalopathy
3) Confidence 0.28 Published 2009 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC2724189 Disease Relevance 1.20 Pain Relevance 0.16
All three patients were concomitantly receiving other immunosuppressive agents preceding the diagnosis of PML.
PML Binding (diagnosis) of associated with progressive multifocal leukoencephalopathy
4) Confidence 0.17 Published 2009 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC2789688 Disease Relevance 1.10 Pain Relevance 0.23
Results from the AFFIRM trial demonstrated that natalizumab decreased relapse rates by 68% at 1 year, reduced sustained disability by 42% over 2 years, and decreased MRI lesion activity.63 Natalizumab therapy is currently only available to patients enrolled in the Tysabri Outreach Unified Commitment to Health (TOUCH®) prescribing program due to its association with progressive multifocal leukoencephalopathy (PML), a rare, demyelinating neurological disorder caused by the reactivation of the JC virus.
PML Binding (association) of associated with progressive multifocal leukoencephalopathy, neurological disease, demyelinating disease, imagery and recurrence
5) Confidence 0.13 Published 2010 Journal Drug Design, Development and Therapy Section Body Doc Link PMC2998807 Disease Relevance 0.95 Pain Relevance 0.17
In addition, a plan has been developed to monitor, evaluate and measure risk factors associated with cases PML and other serious opportunistic infections and regularly report these to FDA.
PML Binding (associated) of associated with opportunistic infections and progressive multifocal leukoencephalopathy
6) Confidence 0.11 Published 2008 Journal AAPS J Section Body Doc Link PMC2751449 Disease Relevance 0.87 Pain Relevance 0.04
Identification of an association between natazulimab with PML emanated from two postmarketing clinical studies to determine the safety and efficacy of this agent in patients with relapsing-remitting forms of the disease that were being performed by the manufacturer at the time of approval.
PML Binding (association) of associated with progressive multifocal leukoencephalopathy and disease
7) Confidence 0.11 Published 2008 Journal AAPS J Section Body Doc Link PMC2751449 Disease Relevance 1.06 Pain Relevance 0.10
As no interactions with AED drugs were described for natalizumab and recent clinical data show that safety may be increased for PML associated with natalizumab therapy [35], our results suggest that anti-adhesion therapies such as natalizumab may complement traditional therapies, and might be useful in treating refractory epilepsy and epilepsy following MS or inflammatory inciting events such as trauma, stroke and infections.
PML Binding (associated) of associated with progressive multifocal leukoencephalopathy, stroke, infection, epilepsy, multiple sclerosis, inflammation, injury and adhesions
8) Confidence 0.07 Published 2010 Journal BMC Neurol Section Body Doc Link PMC2954970 Disease Relevance 2.01 Pain Relevance 0.27
Currently, several initiatives to better understand PML and its management in the context of natalizumab therapy are being planned or conducted.


PML Binding (management) of associated with progressive multifocal leukoencephalopathy
9) Confidence 0.04 Published 2008 Journal Biologics : Targets & Therapy Section Body Doc Link PMC2721353 Disease Relevance 0.54 Pain Relevance 0
However, experience with PML in organ transplant recipients and patients with HIV strongly suggests that reconstitution of the immune system is associated with a better prognosis (Clifford et al 1999; Crowder et al 2005; Shitrit et al 2005).
PML Binding (experience) of in immune system associated with progressive multifocal leukoencephalopathy, acquired immune deficiency syndrome or hiv infection and organ transplantation
10) Confidence 0.04 Published 2008 Journal Biologics : Targets & Therapy Section Body Doc Link PMC2721353 Disease Relevance 1.10 Pain Relevance 0.20

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