INT97063

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Context Info
Confidence 0.77
First Reported 2001
Last Reported 2011
Negated 4
Speculated 0
Reported most in Body
Documents 16
Total Number 16
Disease Relevance 13.81
Pain Relevance 3.13

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell proliferation (CD5) plasma membrane (CD5)
Anatomy Link Frequency
B cells 5
T-cell 2
lymphocytes 1
bone marrow 1
MALT 1
CD5 (Homo sapiens)
Pain Link Frequency Relevance Heat
chemokine 246 99.80 Very High Very High Very High
rheumatoid arthritis 240 98.80 Very High Very High Very High
cytokine 57 95.24 Very High Very High Very High
Pain 10 87.72 High High
Central nervous system 26 85.32 High High
anesthesia 1 85.08 High High
Inflammation 177 84.88 Quite High
metalloproteinase 2 82.76 Quite High
imagery 9 79.68 Quite High
Arthritis 13 78.16 Quite High
Disease Link Frequency Relevance Heat
Diffuse Large B-cell Lymphoma 6 99.98 Very High Very High Very High
Lymphatic System Cancer 134 99.76 Very High Very High Very High
Cancer 47 99.76 Very High Very High Very High
Malignant Neoplastic Disease 13 99.76 Very High Very High Very High
Mantle-cell Lymphoma 13 99.68 Very High Very High Very High
Rheumatoid Arthritis 240 98.80 Very High Very High Very High
Hodgkin's Disease 14 97.48 Very High Very High Very High
Epstein-barr Virus 31 96.84 Very High Very High Very High
Disease 78 95.72 Very High Very High Very High
Chronic Fatigue Syndrome 150 94.76 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Since it was reported that lymphomas with a mantle cell lymphoma morphology and CD5 expression, but without cyclin D1 overexpression, exist in about 10% of mantle cell lymphoma cases, we diagnosed his disease as mantle cell lymphoma.
Gene_expression (expression) of CD5 associated with mantle-cell lymphoma, lymphatic system cancer and disease
1) Confidence 0.77 Published 2001 Journal Hepatogastroenterology Section Abstract Doc Link 11462900 Disease Relevance 0.80 Pain Relevance 0.09
The lack of CD5 expression underscores the importance of performing thorough immunohistochemical studies, particularly to exclude MALT lymphoma.
Gene_expression (expression) of CD5 in MALT associated with lymphatic system cancer
2) Confidence 0.72 Published 2004 Journal Leuk. Lymphoma Section Abstract Doc Link 15359648 Disease Relevance 1.16 Pain Relevance 0.16
The DLBCL expressed CD19, CD20, CD79a, CD5, CD10, CD23, CD38, CD117, bcl-2, and bcl-6, with monotypic expression of immunoglobulin kappa light chain.
Gene_expression (expressed) of CD5 associated with diffuse large b-cell lymphoma
3) Confidence 0.58 Published 2005 Journal Am. J. Clin. Pathol. Section Abstract Doc Link 15842045 Disease Relevance 0.76 Pain Relevance 0.11
The T cells expressed CD2, CD3, CD5, CD7, and CD8, with partial loss of CD4.
Gene_expression (expressed) of CD5 in T cells
4) Confidence 0.58 Published 2005 Journal Am. J. Clin. Pathol. Section Abstract Doc Link 15842045 Disease Relevance 0.73 Pain Relevance 0.10
The DLBCL expressed CD19, CD20, CD79a, CD5, CD10, CD23, CD38, CD117, bcl-2, and bcl-6, with monotypic expression of immunoglobulin kappa light chain.
Gene_expression (expressed) of CD5 associated with diffuse large b-cell lymphoma
5) Confidence 0.50 Published 2005 Journal Am. J. Clin. Pathol. Section Abstract Doc Link 15842045 Disease Relevance 0.76 Pain Relevance 0.11
The lymphoma cells were positive for CD2, CD3, CD5, CD8, and T-cell receptor (TCR) beta F1, but negative for CD4, CD19, CD20, CD103, and CD56.
Neg (negative) Gene_expression (positive) of CD5 in T-cell associated with lymphatic system cancer
6) Confidence 0.48 Published 2003 Journal J. Gastroenterol. Section Abstract Doc Link 12743779 Disease Relevance 0.79 Pain Relevance 0.10
The tumour cells were immunopositivity for CD20 and CD10, expressed weak positivity for CD3, negative for CD5 and showed > 90% positivity for Ki-67.
Neg (negative) Gene_expression (negative) of CD5 associated with cancer
7) Confidence 0.37 Published 2010 Journal Malays J Pathol Section Abstract Doc Link 20614728 Disease Relevance 1.06 Pain Relevance 0.09
Finally, IL-4 downregulates the surface expression of CD5 on B cells and inhibits spontaneous Ig and IgM rheumatoid factor production in patients with RA [77].
Gene_expression (expression) of CD5 in B cells associated with rheumatoid arthritis
8) Confidence 0.32 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC2833981 Disease Relevance 0.81 Pain Relevance 0.40
Comparable frequencies of CD5 expression were found for patients with RA (range 12 to 23% of B cells).
Gene_expression (expression) of CD5 in B cells associated with rheumatoid arthritis
9) Confidence 0.31 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1257429 Disease Relevance 0.60 Pain Relevance 0.36
The tumor cells were immunonegative for CD3, CD5, cyclin D1, CD21, CD23, CD10, and Ig M.
Gene_expression (immunonegative) of CD5 associated with cancer
10) Confidence 0.28 Published 2008 Journal J Hematop Section Body Doc Link PMC2713483 Disease Relevance 0.85 Pain Relevance 0
Staining of PBMC of healthy controls showed that on average 20% of B cells were positive for CD5 (data not shown).
Gene_expression (positive) of CD5 in B cells
11) Confidence 0.27 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1257429 Disease Relevance 0.62 Pain Relevance 0.36
To assess chemokine receptor expression on CD5+ B cells, CD19+ B cells were purified by magnetic cell sorting and stained for CD5, CD27 and the respective chemokine receptor.
Gene_expression (expression) of CD5 in B cells associated with chemokine
12) Confidence 0.27 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1257429 Disease Relevance 0.48 Pain Relevance 0.31
The lymphocytes express B-cell markers (CD19, CD20, and CD79a) and are negative for CD3, CD5, CD10, CD23, and cyclin D1.
Neg (negative) Gene_expression (negative) of CD5 in lymphocytes
13) Confidence 0.25 Published 2008 Journal J Hematop Section Body Doc Link PMC2713483 Disease Relevance 1.47 Pain Relevance 0.26
Flow cytometry of the bone marrow biopsy revealed that the majority of cells were immunoreactive for CD45, CD2, CD3, CD4, and CD30, whereas the expression of CD5 and CD7 was greatly reduced compared to CD2 and CD3.
Gene_expression (expression) of CD5 in bone marrow
14) Confidence 0.20 Published 2007 Journal J Gen Intern Med Section Body Doc Link PMC1824742 Disease Relevance 0.36 Pain Relevance 0
A significant increase in the numbers of B cells with CD20+ CD5+ phenotype which is correlated with autoantibody production and with CD21 markers that is a ligand for retroviruses was also found in patients with CFS [61].
Gene_expression (phenotype) of CD5 in B cells associated with chronic fatigue syndrome
15) Confidence 0.16 Published 2010 Journal Nutr Metab (Lond) Section Body Doc Link PMC2964729 Disease Relevance 1.58 Pain Relevance 0.48
The malignant cells were negative for CD20, CD30, CD45, CD5, Alk-1 and TCK.
Neg (negative) Gene_expression (negative) of CD5 associated with malignant neoplastic disease
16) Confidence 0.08 Published 2011 Journal J Med Case Reports Section Body Doc Link PMC3024289 Disease Relevance 0.98 Pain Relevance 0.22

General Comments

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