INT97068

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.07
First Reported 2001
Last Reported 2008
Negated 0
Speculated 1
Reported most in Body
Documents 1
Total Number 9
Disease Relevance 4.20
Pain Relevance 7.59

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (PISD) lyase activity (PISD)
Anatomy Link Frequency
neurons 7
visceral 2
PISD (Homo sapiens)
Pain Link Frequency Relevance Heat
Dorsal column 503 100.00 Very High Very High Very High
Spinal cord 177 99.60 Very High Very High Very High
intrathecal 32 99.60 Very High Very High Very High
Visceral pain 208 99.12 Very High Very High Very High
Pain 50 99.00 Very High Very High Very High
Inflammation 32 98.40 Very High Very High Very High
Kinase C 72 97.52 Very High Very High Very High
spinothalamic tract 40 96.08 Very High Very High Very High
nMDA receptor 40 94.36 High High
Pain management 8 93.80 High High
Disease Link Frequency Relevance Heat
Irritable Bowel Syndrome /

Irritable Bowel Syndrome Super / Visceral Pain

216 99.12 Very High Very High Very High
Nociception 265 98.68 Very High Very High Very High
INFLAMMATION 32 98.40 Very High Very High Very High
Pain 32 87.32 High High
Cancer 32 76.60 Quite High
Targeted Disruption 8 64.32 Quite High
Stress 8 17.76 Low Low
Inflammatory Pain 8 10.24 Low Low
Neuropathic Pain 8 8.48 Low Low
Hypoxia 8 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
It also suggests that activation of PKA in PSDC neurons might increase CREB-induced the expression of NK1 receptor and contribute to the sensitization of PSDC neurons (Figure 2).
Gene_expression (neurons) of PSDC in neurons associated with dorsal column
1) Confidence 0.07 Published 2008 Journal Mol Pain Section Body Doc Link PMC2584043 Disease Relevance 0.20 Pain Relevance 0.90
An increased expression of neurokinin NK1 receptors in PSDC neurons was demonstrated after colonic inflammation or bladder irritation [25,29].
Gene_expression (expression) of PSDC in neurons associated with inflammation and dorsal column
2) Confidence 0.07 Published 2008 Journal Mol Pain Section Body Doc Link PMC2584043 Disease Relevance 0.39 Pain Relevance 0.99
Role of the PSDC pathway and PSDC neurons in the transmission of visceral nociception
Gene_expression (pathway) of PSDC in neurons associated with nociception and dorsal column
3) Confidence 0.07 Published 2008 Journal Mol Pain Section Body Doc Link PMC2584043 Disease Relevance 0.48 Pain Relevance 1.02
We found that intracolonic injection of mustard oil significantly induced the expression of PKA kinase protein, as well as CREB, in the lumbosacral spinal cord and in pre-labeled PSDC neurons.
Gene_expression (neurons) of PSDC in neurons associated with dorsal column and spinal cord
4) Confidence 0.07 Published 2008 Journal Mol Pain Section Body Doc Link PMC2584043 Disease Relevance 0.56 Pain Relevance 0.79
Another important role for the activation of PKA in PSDC neurons is that PKA may mediate painful stimulation-elicited gene expression through its regulation of transcription factors, such as c-fos and CREB [33,35,40,45].
Gene_expression (neurons) of PSDC in neurons associated with pain and dorsal column
5) Confidence 0.07 Published 2008 Journal Mol Pain Section Body Doc Link PMC2584043 Disease Relevance 0.12 Pain Relevance 0.89
This study was conducted to ascertain the possible expression of Fos-like immunoreactivity (Fos-LI) in the postsynaptic dorsal column (PSDC) neurons in response to noxious mechanical stimulation of the forepaw glabrous area of normal rats.
Spec (possible) Gene_expression (expression) of PSDC in neurons associated with dorsal column
6) Confidence 0.06 Published 2001 Journal Neurosci. Res. Section Abstract Doc Link 11463480 Disease Relevance 0 Pain Relevance 0.25
Our group demonstrated the intracellular cascade in PSDC neurons mediated by PKA in a visceral pain model in rats with the intracolonic injection of mustard oil [41,42].
Gene_expression (neurons) of PSDC in visceral associated with visceral pain and dorsal column
7) Confidence 0.06 Published 2008 Journal Mol Pain Section Body Doc Link PMC2584043 Disease Relevance 0.74 Pain Relevance 0.78
Activation of signal transduction pathways in PSDC neurons in response to visceral stimuli
Gene_expression (neurons) of PSDC in visceral associated with dorsal column
8) Confidence 0.06 Published 2008 Journal Mol Pain Section Body Doc Link PMC2584043 Disease Relevance 0.21 Pain Relevance 0.97
Role of the PSDC pathway and PSDC neurons in the transmission of visceral nociception
Gene_expression (neurons) of PSDC in neurons associated with nociception and dorsal column
9) Confidence 0.06 Published 2008 Journal Mol Pain Section Body Doc Link PMC2584043 Disease Relevance 0.48 Pain Relevance 0.99

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox