INT97071

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Context Info
Confidence 0.43
First Reported 2001
Last Reported 2010
Negated 0
Speculated 2
Reported most in Abstract
Documents 1
Total Number 3
Disease Relevance 0.59
Pain Relevance 1.00

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Gstp1) plasma membrane (Gstp1) nucleus (Gstp1)
intracellular (Gstp1) protein complex (Gstp1) cytoplasm (Gstp1)
Anatomy Link Frequency
hepatocytes 2
Gstp1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Paracetamol 18 100.00 Very High Very High Very High
anesthesia 1 5.00 Very Low Very Low Very Low
Inflammatory response 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Hyperplasia 4 100.00 Very High Very High Very High
Cancer 10 89.68 High High
Hepatotoxicity 2 71.60 Quite High
Targeted Disruption 15 50.00 Quite Low
Lymphatic System Cancer 1 30.40 Quite Low
Sprains And Strains 15 5.00 Very Low Very Low Very Low
Body Weight 5 5.00 Very Low Very Low Very Low
Toxicity 3 5.00 Very Low Very Low Very Low
Apoptosis 1 5.00 Very Low Very Low Very Low
Hypertrophy 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Effects of acetaminophen (AAP) pretreatment on hepatic aflatoxin B1 (AFB(1))-DNA binding, cellular proliferation, and AFB(1)-induced glutathione S-transferase placental form (GST-P) positive hepatocytes and foci have been examined in young male rats and hamsters.
Spec (examined) Regulation (Effects) of GST-P in hepatocytes associated with paracetamol and hyperplasia
1) Confidence 0.43 Published 2001 Journal Cancer Lett. Section Abstract Doc Link 11463488 Disease Relevance 0.17 Pain Relevance 0.50
Effects of acetaminophen (AAP) pretreatment on hepatic aflatoxin B1 (AFB(1))-DNA binding, cellular proliferation, and AFB(1)-induced glutathione S-transferase placental form (GST-P) positive hepatocytes and foci have been examined in young male rats and hamsters.
Spec (examined) Regulation (Effects) of glutathione S-transferase placental in hepatocytes associated with paracetamol and hyperplasia
2) Confidence 0.43 Published 2001 Journal Cancer Lett. Section Abstract Doc Link 11463488 Disease Relevance 0.17 Pain Relevance 0.50
We hypothesized that we could integrate a genotoxicity assay with a short-term carcinogenicity assay utilizing GST-P foci in F344 gpt delta rats.
Regulation (utilizing) of GST-P
3) Confidence 0.10 Published 2010 Journal Toxicological Sciences Section Body Doc Link PMC2819973 Disease Relevance 0.24 Pain Relevance 0

General Comments

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