INT97073

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Context Info
Confidence 0.42
First Reported 2001
Last Reported 2010
Negated 0
Speculated 1
Reported most in Body
Documents 6
Total Number 8
Disease Relevance 2.68
Pain Relevance 1.80

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

isomerase activity (Ebp) endoplasmic reticulum (Ebp)
Anatomy Link Frequency
blood 1
germline 1
heart 1
MLH1 1
Ebp (Mus musculus)
Pain Link Frequency Relevance Heat
epidural 6 100.00 Very High Very High Very High
action potential duration 12 99.56 Very High Very High Very High
Analgesic 1 98.48 Very High Very High Very High
agonist 8 97.64 Very High Very High Very High
Pain 5 95.60 Very High Very High Very High
lidocaine 3 93.60 High High
headache 12 92.32 High High
antagonist 3 76.36 Quite High
intrathecal 1 50.00 Quite Low
Sciatica 2 25.00 Low Low
Disease Link Frequency Relevance Heat
Cancer 232 99.88 Very High Very High Very High
Arrhythmia Under Development 3 98.92 Very High Very High Very High
Pain 3 95.60 Very High Very High Very High
Tinnitus 1 93.44 High High
Vomiting 2 93.04 High High
Headache 3 92.32 High High
Post-dural Puncture Headache 7 89.76 High High
Lumbar Puncture Related Headaches 2 83.16 Quite High
Apoptosis 82 69.20 Quite High
Recurrence 3 67.84 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Resistant cases might require an epidural blood patch (EBP).
Spec (might) Positive_regulation (require) of EBP in blood associated with epidural
1) Confidence 0.42 Published 2010 Journal Pain Physician Section Abstract Doc Link 20495590 Disease Relevance 1.04 Pain Relevance 1.08
Regression analysis confirmed a significant direct linear relationship between increasing EBP volumes and worsening adverse neurological outcomes (P = 0.008).
Positive_regulation (increasing) of EBP
2) Confidence 0.40 Published 2005 Journal Pain Pract Section Body Doc Link 17147583 Disease Relevance 0 Pain Relevance 0
Of these, 1 patient who received saline required EBP compared with nine in the control group (P =.004).
Positive_regulation (required) of EBP
3) Confidence 0.34 Published 2001 Journal Reg Anesth Pain Med Section Body Doc Link 11464346 Disease Relevance 0.06 Pain Relevance 0
TdP was induced by an I(Kr) blocker, clofilium, in anesthetized, alpha(1)-agonist-sensitized rabbits.
Positive_regulation (induced) of TdP associated with agonist
4) Confidence 0.18 Published 2008 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 18322148 Disease Relevance 0.10 Pain Relevance 0.24
Clofilium prolonged QT interval corrected for heart rate (QTc) (52 +/- 9%) and monophasic action potential duration (MAPD)(90) (56 +/- 9%) and caused TdP in eight of eight rabbits.
Positive_regulation (caused) of TdP in heart associated with action potential duration
5) Confidence 0.16 Published 2008 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 18322148 Disease Relevance 0.15 Pain Relevance 0.28
We conclude that ranolazine antagonizes the ventricular repolarization changes caused by clofilium and suppresses clofilium-induced TdP in rabbits.
Positive_regulation (induced) of TdP
6) Confidence 0.16 Published 2008 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 18322148 Disease Relevance 0.07 Pain Relevance 0.20
Almost all described MLH1/MSH2 mutations cause MSI-H tumors, although recently MSS MLH1 non-synonymous amino acid substitutions causing deleterious mutations have been described (32,33).
Positive_regulation (cause) of MSI in MLH1 associated with cancer
7) Confidence 0.11 Published 2006 Journal Nucleic Acids Research Section Body Doc Link PMC1361617 Disease Relevance 0.63 Pain Relevance 0
However, it has been suggested that cells from subjects carrying heterozygous germline mutations may have detectable MSI using a more sensitive assay referred to as single-molecule or small pool PCR (34,35) that can detect approximately 5- to 10-fold elevations in MSI rates.
Positive_regulation (elevations) of MSI in germline
8) Confidence 0.10 Published 2006 Journal Nucleic Acids Research Section Body Doc Link PMC1361617 Disease Relevance 0.63 Pain Relevance 0

General Comments

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