INT97077

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Context Info
Confidence 0.78
First Reported 2000
Last Reported 2007
Negated 0
Speculated 0
Reported most in Body
Documents 16
Total Number 36
Disease Relevance 11.89
Pain Relevance 6.47

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Link Frequency
vasculature 5
platelet 3
dendritic cells 2
glial cells 2
B lymphocyte 2
Entpd1 (Mus musculus)
Pain Link Frequency Relevance Heat
Peripheral nervous system 33 99.96 Very High Very High Very High
tolerance 21 99.12 Very High Very High Very High
Inflammation 337 98.64 Very High Very High Very High
Inflammatory response 27 98.24 Very High Very High Very High
cytokine 178 98.12 Very High Very High Very High
antagonist 793 97.56 Very High Very High Very High
agonist 264 96.76 Very High Very High Very High
Angina 19 96.52 Very High Very High Very High
adenocard 668 94.64 High High
Central nervous system 105 90.72 High High
Disease Link Frequency Relevance Heat
Targeted Disruption 68 99.88 Very High Very High Very High
Atherosclerosis 2 99.48 Very High Very High Very High
Hypoxia 42 98.72 Very High Very High Very High
Melanoma 21 98.68 Very High Very High Very High
INFLAMMATION 295 98.64 Very High Very High Very High
Vasculitis 110 98.60 Very High Very High Very High
Stress 176 98.24 Very High Very High Very High
Acute Coronary Syndrome 2 97.52 Very High Very High Very High
Cardiovascular Disease 21 97.36 Very High Very High Very High
Thrombosis 48 97.04 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Systemic administration of soluble derivatives of CD39 or targeted expression of the native protein to sites of vascular injury may have future therapeutic application.
Gene_expression (expression) of CD39 associated with vasculitis
1) Confidence 0.78 Published 2000 Journal Curr Drug Targets Section Abstract Doc Link 11465076 Disease Relevance 0.49 Pain Relevance 0.11
CD39, the ATP diphosphohydrolase (ATPDase) expressed on quiescent vascular endothelium, modulates platelet purinoreceptor activity by the sequential hydrolysis of extracellular ATP or ADP directly to AMP.
Gene_expression (expressed) of ATP diphosphohydrolase in platelet
2) Confidence 0.78 Published 2000 Journal Curr Drug Targets Section Abstract Doc Link 11465076 Disease Relevance 0.54 Pain Relevance 0.15
This thromboregulatory potential of CD39 has been recently demonstrated by the generation of mutant mice with disruption of the gene, and by a series of experiments where high level ATPDase expression has been attained by adenoviral vectors in the injured vasculature.
Gene_expression (expression) of ATPDase in vasculature
3) Confidence 0.78 Published 2000 Journal Curr Drug Targets Section Abstract Doc Link 11465076 Disease Relevance 0.43 Pain Relevance 0.12
CD39, the ATP diphosphohydrolase (ATPDase) expressed on quiescent vascular endothelium, modulates platelet purinoreceptor activity by the sequential hydrolysis of extracellular ATP or ADP directly to AMP.
Gene_expression (expressed) of ATPDase in platelet
4) Confidence 0.78 Published 2000 Journal Curr Drug Targets Section Abstract Doc Link 11465076 Disease Relevance 0.53 Pain Relevance 0.15
These results suggest that CD39 expressed in atheromatous plaque plays an important role in preventing acute coronary syndromes.
Gene_expression (expressed) of CD39 in plaque associated with acute coronary syndrome
5) Confidence 0.76 Published 2005 Journal Am. J. Cardiol. Section Abstract Doc Link 15721107 Disease Relevance 0.96 Pain Relevance 0.62
To determine whether the expression of CD39 in coronary atherosclerotic lesions is related to plaque instability and thrombus formation, we assessed directional coronary atherectomy (DCA) specimens from patients with stable and unstable angina pectoris.
Gene_expression (expression) of CD39 in plaque associated with angina, atherosclerosis and thrombosis
6) Confidence 0.76 Published 2005 Journal Am. J. Cardiol. Section Abstract Doc Link 15721107 Disease Relevance 0.83 Pain Relevance 0.56
The selective expression of CD39 by Treg and the question whether this ectonucleotidase and/or extracellular nucleotides influence(s) the function of these interesting cells is a focus of current work.


Gene_expression (expression) of CD39
7) Confidence 0.71 Published 2006 Journal Purinergic Signal Section Body Doc Link PMC2254478 Disease Relevance 0.08 Pain Relevance 0.16
The modulated expression of NTPDase1 has been closely associated with inflammatory cytokines, oxidative stress and hypoxia in vitro and in vivo [19, 90].
Gene_expression (expression) of NTPDase1 associated with stress, inflammation, hypoxia and cytokine
8) Confidence 0.71 Published 2006 Journal Purinergic Signal Section Body Doc Link PMC2254478 Disease Relevance 0.51 Pain Relevance 0.17
In mouse, rat and porcine kidneys, NTPDase1 can be detected in vascular structures, including blood vessels of glomerular and peritubular capillaries [174, 199, 200].
Gene_expression (detected) of NTPDase1 in blood vessels
9) Confidence 0.71 Published 2006 Journal Purinergic Signal Section Body Doc Link PMC2254478 Disease Relevance 0.20 Pain Relevance 0.12
Expression of NTPDase1 is increased in differentiating melanomas followed by a gradual decrease with tumor progression [91] and enhanced NTPDase1 activity of stimulated endothelial and mesangial cells is downregulated by glucocorticosteroids [92].
Gene_expression (Expression) of NTPDase1 in mesangial cells associated with cancer and melanoma
10) Confidence 0.71 Published 2006 Journal Purinergic Signal Section Body Doc Link PMC2254478 Disease Relevance 0.55 Pain Relevance 0.17
This was then followed by the functional expression of human CD39 and the demonstration that this protein was in fact an ecto-apyrase [43].
Gene_expression (expression) of CD39
11) Confidence 0.71 Published 2006 Journal Purinergic Signal Section Body Doc Link PMC2254478 Disease Relevance 0 Pain Relevance 0
In keeping with these biochemical properties, NTPDase1 is dominantly expressed by endothelial cells and the associated vascular smooth muscle where it serves as a thromboregulatory factor.
Gene_expression (expressed) of NTPDase1 in endothelial cells
12) Confidence 0.71 Published 2006 Journal Purinergic Signal Section Body Doc Link PMC2254478 Disease Relevance 0.22 Pain Relevance 0.20
Modulated, distinct NTPDase expression appears to regulate nucleotide-mediated signaling in essentially every tissue, including the vasculature and of immune and nervous systems.
Gene_expression (expression) of NTPDase in nervous systems
13) Confidence 0.71 Published 2006 Journal Purinergic Signal Section Body Doc Link PMC2254478 Disease Relevance 0.27 Pain Relevance 0.06
Similarly cultured normal and immortalized pituitary and hypothalamic cells express NTPDase1-3 [116].
Gene_expression (express) of NTPDase1 in pituitary
14) Confidence 0.71 Published 2006 Journal Purinergic Signal Section Body Doc Link PMC2254478 Disease Relevance 0.10 Pain Relevance 0.32
To date, there is only scattered evidence on promoters and the factors controlling NTPDase expression [22].
Gene_expression (expression) of NTPDase
15) Confidence 0.71 Published 2006 Journal Purinergic Signal Section Body Doc Link PMC2254478 Disease Relevance 0.35 Pain Relevance 0.12
Alternatively, microglial expression of NTPDase1 might contribute to preventing receptor desensitization on prolonged exposure to elevated ATP levels.
Gene_expression (expression) of NTPDase1 associated with antagonist
16) Confidence 0.71 Published 2006 Journal Purinergic Signal Section Body Doc Link PMC2254478 Disease Relevance 0.30 Pain Relevance 0.42
To test how extracellular nucleotide-mediated signaling influences pathophysiological events, several techniques have been developed and validated to manipulate NTPDase1 expression in the vasculature and to study conditions of inflammatory stress.
Gene_expression (expression) of NTPDase1 in vasculature associated with stress and inflammation
17) Confidence 0.71 Published 2006 Journal Purinergic Signal Section Body Doc Link PMC2254478 Disease Relevance 0.38 Pain Relevance 0.08
CD39, the ATP diphosphohydrolase (ATPDase) expressed on quiescent vascular endothelium, modulates platelet purinoreceptor activity by the sequential hydrolysis of extracellular ATP or ADP directly to AMP.
Gene_expression (expressed) of CD39 in platelet
18) Confidence 0.68 Published 2000 Journal Curr Drug Targets Section Abstract Doc Link 11465076 Disease Relevance 0.54 Pain Relevance 0.15
The future planned use of transgenic mice expressing fluorescent protein under the promoter of the respective NTPDase isoform will greatly facilitate the identification of the expression pattern of individual enzyme isoforms in the developing and adult nervous system.


Gene_expression (expressing) of NTPDase isoform in adult nervous system associated with targeted disruption
19) Confidence 0.62 Published 2006 Journal Purinergic Signal Section Body Doc Link PMC2254478 Disease Relevance 0.10 Pain Relevance 0.41
Members of the E-NTPDase family are constitutively expressed in many tissues.
Gene_expression (expressed) of NTPDase
20) Confidence 0.62 Published 2006 Journal Purinergic Signal Section Body Doc Link PMC2254478 Disease Relevance 0.30 Pain Relevance 0.11

General Comments

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