INT97092

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Context Info
Confidence 0.27
First Reported 2001
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 2
Disease Relevance 0.31
Pain Relevance 0

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleoplasm (PRKCA) mitochondrion (PRKCA) small molecule metabolic process (PRKCA)
endoplasmic reticulum (PRKCA) enzyme binding (PRKCA) cytoplasm (PRKCA)
Anatomy Link Frequency
fibroblasts 2
PRKCA (Homo sapiens)
Pain Link Frequency Relevance Heat
local anesthetic 5 50.00 Quite Low
Inflammation 4 5.00 Very Low Very Low Very Low
anesthesia 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Obesity 51 74.24 Quite High
Disorder Of Lipid Metabolism 21 57.24 Quite High
Atherosclerosis 7 5.00 Very Low Very Low Very Low
Cardiovascular Disease 4 5.00 Very Low Very Low Very Low
INFLAMMATION 4 5.00 Very Low Very Low Very Low
Diabetes Mellitus 1 5.00 Very Low Very Low Very Low
Overweight 1 5.00 Very Low Very Low Very Low
Stress 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Using protein kinase C (PKC) inhibitors, the PKC activator phorbol myristate acetate (PMA), and the phospholipase C (PLC) antagonist U-73122, we studied involvement of PKC and PLC in the priming process.
Positive_regulation (Using) of Negative_regulation (inhibitors) of PKC
1) Confidence 0.27 Published 2001 Journal Anesthesiology Section Body Doc Link 11465548 Disease Relevance 0 Pain Relevance 0
Finally, it is also known that PKC activators are capable of activating cholesterol efflux in fibroblasts, vascular smooth muscle cells, and in human macrophages [14,15], whereas inhibitors of PKC lead to a reduction in apoA-I induced efflux [16].
Positive_regulation (lead) of Negative_regulation (inhibitors) of PKC in fibroblasts
2) Confidence 0.19 Published 2010 Journal Lipids Health Dis Section Body Doc Link PMC2917427 Disease Relevance 0.31 Pain Relevance 0

General Comments

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