INT97096

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Context Info
Confidence 0.61
First Reported 2001
Last Reported 2010
Negated 1
Speculated 4
Reported most in Body
Documents 18
Total Number 22
Disease Relevance 6.42
Pain Relevance 3.90

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

endoplasmic reticulum (Hmox1) enzyme binding (Hmox1) signal transducer activity (Hmox1)
cytosol (Hmox1) signal transduction (Hmox1) cell death (Hmox1)
Anatomy Link Frequency
liver 4
hippocampus 2
hypothalamus 2
Hepatocytes 1
epithelial cells 1
Hmox1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Hippocampus 44 100.00 Very High Very High Very High
Paracetamol 18 100.00 Very High Very High Very High
cINOD 16 99.82 Very High Very High Very High
cytokine 73 98.60 Very High Very High Very High
isoflurane 3 98.06 Very High Very High Very High
ketamine 6 97.66 Very High Very High Very High
Inflammatory response 12 97.56 Very High Very High Very High
Pain 3 95.96 Very High Very High Very High
Inflammation 136 91.56 High High
anesthesia 15 90.48 High High
Disease Link Frequency Relevance Heat
Hypotension 1 100.00 Very High Very High Very High
Injury 58 99.32 Very High Very High Very High
Nociception 6 98.64 Very High Very High Very High
INFLAMMATION 156 97.20 Very High Very High Very High
Pain 1 95.96 Very High Very High Very High
Stress 63 95.40 Very High Very High Very High
Apoptosis 105 93.60 High High
Sepsis 29 92.24 High High
Breast Cancer 4 92.06 High High
Death 8 90.92 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Up regulation of HO-1 in the liver following acetaminophen administration correlated with induction of ferritin and manganese superoxide dismutase (MnSOD).
Regulation (regulation) of HO-1 in liver associated with paracetamol
1) Confidence 0.61 Published 2002 Journal Toxicol. Appl. Pharmacol. Section Abstract Doc Link 12051994 Disease Relevance 0.38 Pain Relevance 0.60
The present study was undertaken to consider the regulation of HO-1 and HO-2 n the human airway wall, and to suggest a probable role that HOs may play in cellular defense against oxidative stress due to SM.
Regulation (regulation) of HO associated with stress
2) Confidence 0.60 Published 2010 Journal Gene Regul Syst Bio Section Abstract Doc Link PMC2956478 Disease Relevance 0.27 Pain Relevance 0
Ketamine has hepatoprotective effects against LPS-induced liver injury that appear to be mediated, at least in part, by differential modulation of the oxidative stress proteins iNOS and HO-1.
Regulation (modulation) of HO-1 in liver
3) Confidence 0.60 Published 2005 Journal J Trauma Section Body Doc Link 15824646 Disease Relevance 0.06 Pain Relevance 0
To examine the mechanisms for the effects of HO-1 on leukocyte and platelet behavior, these studies were repeated with superfusion of either CO, bilirubin, or Nomega-nitro-L-arginine methyl ester (L-NAME).
Spec (examine) Regulation (effects) of HO-1 in platelet
4) Confidence 0.45 Published 2001 Journal Anesthesiology Section Body Doc Link 11465558 Disease Relevance 0 Pain Relevance 0
Here, we have examined up-regulation of HO-1 by NSAIDs and the contribution of HO-1 to the protection of gastric mucosal cells against NSAIDs both in vitro and in vivo.
Spec (examined) Regulation (contribution) of HO-1 associated with cinod
5) Confidence 0.45 Published 2006 Journal J. Biol. Chem. Section Abstract Doc Link 16945925 Disease Relevance 0.55 Pain Relevance 1.05
The HO system has been implicated in the regulation of blood pressure and the blood pressure lowering effect of HO-1 induction has been attributed to various mechanisms, including decreased production of vasoconstrictor eicosanoids and increased production of CO [15].
Regulation (regulation) of HO in blood associated with hypotension
6) Confidence 0.42 Published 2008 Journal International Journal of Molecular Sciences Section Body Doc Link PMC2635644 Disease Relevance 0.93 Pain Relevance 0.04
Of note, exogenous application of CORM-2 had an augmenting effect on the expression levels of HO-1, indicating that the exogenous addition of one of the reaction products of HO-1 has a positive feed forward effect on HO-1 expression.
Regulation (effect) of HO-1
7) Confidence 0.29 Published 2010 Journal BMC Gastroenterol Section Body Doc Link PMC2873601 Disease Relevance 0.81 Pain Relevance 0.31
In contrast to the up-regulation at mRNA level, immunohistochemistry staining revealed no change at protein level of HO-1 in bronchial epithelial cells in SM exposed group and we were countered with a discrepancy between mRNA and protein levels of HO-1, whereas we detected HO-1 immonopositivity in the unexposed group.
Neg (no) Regulation (change) of HO in epithelial cells
8) Confidence 0.26 Published 2010 Journal Gene Regul Syst Bio Section Body Doc Link PMC2956478 Disease Relevance 0.77 Pain Relevance 0.04
The present study was undertaken to consider the regulation of HO-1 and HO-2 n the human airway wall, and to suggest a probable role that HOs may play in cellular defense against oxidative stress due to SM.
Regulation (regulation) of HO associated with stress
9) Confidence 0.26 Published 2010 Journal Gene Regul Syst Bio Section Abstract Doc Link PMC2956478 Disease Relevance 0.27 Pain Relevance 0
For instance, Bruggink showed in patients with end-stage heart failure, cathepsin K protein after Left Ventricular Assist Device (LVAD) decreased in macrophage, while its mRNA levels have been upregulated during LVAD treatment.36 Other research about the role of Peroxiredoxins (Prxs), a recent group of peroxidases with high antioxidant activity in breast cancer revealed low expression of PrxI, II, v and vI proteins in contrast with high levels of mRNA.34 Although cited research has been focused on different tissues and molecules in comparison to our study, these kinds of paradoxical discrepancies between mRNA and protein level of HO-1 may be explained by translational and post translational alterations as mentioned in these studies.34 Conformational alterations of HO-1 protein following unclear mutations after SM exposure could be one of the reasons for this discrepancy.35 Another hypothesis offers destabilizing of HO-1 protein via phosphorylation and over oxidation which culminate in protein degradation35 which might refer to the secondary effect of SM.
Regulation (alterations) of HO in heart associated with breast cancer and myocardial infarction
10) Confidence 0.26 Published 2010 Journal Gene Regul Syst Bio Section Body Doc Link PMC2956478 Disease Relevance 0.23 Pain Relevance 0
We hypothesized that ketamine, but not isoflurane, would attenuate lipopolysaccharide (LPS)-induced liver injury through differential modulation of iNOS and HO-1.
Regulation (modulation) of HO-1 in liver associated with ketamine, injury and isoflurane
11) Confidence 0.26 Published 2005 Journal J Trauma Section Abstract Doc Link 15824646 Disease Relevance 0.75 Pain Relevance 0.36
RESULTS: LPS significantly increased serum aspartate aminotransferase levels, iNOS, and HO-1 immunoreactivity in the liver.
Regulation (immunoreactivity) of HO-1 in liver
12) Confidence 0.26 Published 2005 Journal J Trauma Section Body Doc Link 15824646 Disease Relevance 0.08 Pain Relevance 0
Changes of HO-1 mRNA (Figure 1)

In both the hypothalamus and hippocampus, HO-1 mRNA levels were significantly increased 6 hr after the injection of LPS.

Regulation (Changes) of HO-1 mRNA in hippocampus associated with hippocampus
13) Confidence 0.26 Published 2008 Journal Neuropsychiatric Disease and Treatment Section Body Doc Link PMC2526382 Disease Relevance 0 Pain Relevance 0.12
Changes of HO-1 mRNA (Figure 1)

In both the hypothalamus and hippocampus, HO-1 mRNA levels were significantly increased 6 hr after the injection of LPS.

Regulation (Changes) of HO-1 mRNA in hippocampus associated with hippocampus
14) Confidence 0.26 Published 2008 Journal Neuropsychiatric Disease and Treatment Section Body Doc Link PMC2526382 Disease Relevance 0 Pain Relevance 0.12
Hepatocytes were found to be more sensitive than macrophages to the effects of acetaminophen on HO-1.
Regulation (effects) of HO-1 in Hepatocytes associated with paracetamol
15) Confidence 0.23 Published 2002 Journal Toxicol. Appl. Pharmacol. Section Abstract Doc Link 12051994 Disease Relevance 0.38 Pain Relevance 0.61
Interestingly, CORM-2 but not iCORM-2 treatment induced a further significant up-regulation of HO-1 (Fig. 3A and 3C, p < 0.05).
Regulation (regulation) of HO-1
16) Confidence 0.21 Published 2010 Journal BMC Gastroenterol Section Body Doc Link PMC2873601 Disease Relevance 0.45 Pain Relevance 0.11
The aim of the present study was to investigate the role of the peripheral heme oxygenase (HO)-carbon monoxide (CO) pathway on nociceptive response of rats to the formalin experimental model of pain.
Spec (investigate) Regulation (role) of HO associated with nociception and pain
17) Confidence 0.18 Published 2007 Journal Eur. J. Pharmacol. Section Abstract Doc Link 17182031 Disease Relevance 0.33 Pain Relevance 0.10
To examine the mechanisms for the effects of HO-1 on leukocyte and platelet behavior, these studies were repeated with superfusion of either CO, bilirubin, or Nomega-nitro-L-arginine methyl ester (L-NAME).
Spec (examine) Regulation (effects) of HO-1 in leukocyte
18) Confidence 0.15 Published 2001 Journal Anesthesiology Section Body Doc Link 11465558 Disease Relevance 0 Pain Relevance 0
At the same time, the concentration of HO-1 protein, a positive control for APR, peaked at 12 h during APR, as previously described, confirming successful APR induction (Tron et al. 2005; Fig. 6a, b).
Regulation (control) of HO-1
19) Confidence 0.09 Published 2010 Journal Cell Tissue Res Section Body Doc Link PMC2977073 Disease Relevance 0 Pain Relevance 0
Changes of HO-1 mRNA (Figure 1)

In both the hypothalamus and hippocampus, HO-1 mRNA levels were significantly increased 6 hr after the injection of LPS.

Regulation (Changes) of HO-1 mRNA in hypothalamus associated with hippocampus
20) Confidence 0.09 Published 2008 Journal Neuropsychiatric Disease and Treatment Section Body Doc Link PMC2526382 Disease Relevance 0 Pain Relevance 0.12

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