INT97100

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Context Info
Confidence 0.58
First Reported 2001
Last Reported 2009
Negated 0
Speculated 2
Reported most in Abstract
Documents 16
Total Number 20
Disease Relevance 6.18
Pain Relevance 14.36

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (Dlg4) protein complex assembly (Dlg4) response to stress (Dlg4)
cytoplasm (Dlg4)
Anatomy Link Frequency
shell 2
spinal 2
spinal cord 2
nerve 2
spike 1
Dlg4 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
neuralgia 12 100.00 Very High Very High Very High
Spinal cord 6 100.00 Very High Very High Very High
Morphine 53 99.70 Very High Very High Very High
Nucleus accumbens 27 99.68 Very High Very High Very High
gABA 13 99.26 Very High Very High Very High
dopamine receptor 4 99.06 Very High Very High Very High
Neuropathic pain 17 99.00 Very High Very High Very High
Lasting pain 4 98.98 Very High Very High Very High
Opioid 8 98.76 Very High Very High Very High
tolerance 8 98.48 Very High Very High Very High
Disease Link Frequency Relevance Heat
Nervous System Injury 12 99.84 Very High Very High Very High
Recurrence 3 99.04 Very High Very High Very High
Neuropathic Pain 21 99.00 Very High Very High Very High
Pain 5 98.98 Very High Very High Very High
Depression 13 97.88 Very High Very High Very High
Hyperalgesia 17 96.44 Very High Very High Very High
Amnesia 2 96.10 Very High Very High Very High
Apoptosis 2 94.40 High High
Nociception 2 91.84 High High
Cognitive Disorder 11 90.92 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Effect of the deficiency of spinal PSD-95/SAP90 on the minimum alveolar anesthetic concentration of isoflurane in rats.
Negative_regulation (deficiency) of SAP90 in spinal associated with isoflurane
1) Confidence 0.58 Published 2001 Journal Anesthesiology Section Title Doc Link 11465592 Disease Relevance 0.09 Pain Relevance 0.28
Effect of the deficiency of spinal PSD-95/SAP90 on the minimum alveolar anesthetic concentration of isoflurane in rats.
Negative_regulation (deficiency) of PSD-95 in spinal associated with isoflurane
2) Confidence 0.58 Published 2001 Journal Anesthesiology Section Title Doc Link 11465592 Disease Relevance 0.09 Pain Relevance 0.28
Our results indicate that the deficiency of postsynaptic density protein-95 protein in the spinal cord significantly attenuates nerve injury-induced mechanical and thermal hyperalgesia during both the development and maintenance of chronic neuropathic pain.
Negative_regulation (deficiency) of postsynaptic density protein-95 in spinal cord associated with nervous system injury, thermal hyperalgesia, neuropathic pain and spinal cord
3) Confidence 0.58 Published 2003 Journal Neuroscience Section Abstract Doc Link 12617977 Disease Relevance 0.90 Pain Relevance 0.90
An interesting finding was the observation that high levels of network activity were associated with gradual increases in PSD-95:GFP puncta numbers, whereas suppressed activity levels were associated with gradual decreases in PSD-95:GFP puncta numbers (see also [82],[83]).
Negative_regulation (decreases) of PSD-95
4) Confidence 0.50 Published 2009 Journal PLoS Biology Section Body Doc Link PMC2693930 Disease Relevance 0.07 Pain Relevance 0
To address the role of PSD-95/SAP90 in chronic pain, the present study investigated the effect of the deficiency of PSD-95/SAP90 on nerve injury-induced neuropathic pain.
Spec (investigated) Negative_regulation (deficiency) of PSD-95 in nerve associated with nervous system injury, lasting pain and neuropathic pain
5) Confidence 0.43 Published 2001 Journal Neuroreport Section Abstract Doc Link 11711866 Disease Relevance 0.79 Pain Relevance 0.74
Knockdown of PSD-95/SAP90 delays the development of neuropathic pain in rats.
Negative_regulation (Knockdown) of PSD-95 associated with neuralgia and neuropathic pain
6) Confidence 0.43 Published 2001 Journal Neuroreport Section Title Doc Link 11711866 Disease Relevance 0.77 Pain Relevance 1.05
At the end of each experiment, spike counts per electrode were extracted from the electrophysiological recordings, and the numbers of PSD-95:GFP puncta and their respective fluorescence intensities were extracted from maximal intensity projections of Z-stacks for each time point and each site (see Materials and Methods).
Negative_regulation (numbers) of PSD-95 in spike
7) Confidence 0.42 Published 2009 Journal PLoS Biology Section Body Doc Link PMC2693930 Disease Relevance 0 Pain Relevance 0.08
The real-time polymerase chain reaction results showed that prenatal morphine exposure caused significant decreases in mRNA levels of the PSD-95 and three NMDAR subunits (NR1, NR2A, and NR2B) in offspring (P14 and P45).
Negative_regulation (decreases) of PSD-95 associated with morphine
8) Confidence 0.41 Published 2009 Journal Neuroscience Section Abstract Doc Link 19041927 Disease Relevance 0.16 Pain Relevance 0.65
The present study indicates that the deficiency of spinal cord PSD-95 attenuates the development of opioid tolerance.
Negative_regulation (deficiency) of PSD-95 in spinal cord associated with tolerance, opioid and spinal cord
9) Confidence 0.38 Published 2004 Journal Neuroscience Section Abstract Doc Link 14667437 Disease Relevance 0 Pain Relevance 1.43
Furthermore, this was seen for both the entire PSD-95:GFP population and for the smaller population of tracked PSD-95:GFP puncta (Figure S5B), indicating that the population of tracked puncta faithfully represented the entire PSD-95:GFP puncta population.
Negative_regulation (represented) of PSD-95
10) Confidence 0.37 Published 2009 Journal PLoS Biology Section Body Doc Link PMC2693930 Disease Relevance 0 Pain Relevance 0.28
Similarly, at the protein level, immunoblotting showed that decreased whole levels of PSD-95 and NMDAR subunits were seen in offspring subjected with prenatal morphine.
Negative_regulation (decreased) of PSD-95 associated with morphine
11) Confidence 0.36 Published 2009 Journal Neuroscience Section Abstract Doc Link 19041927 Disease Relevance 0.15 Pain Relevance 0.75
Collectively, the study demonstrates that maternal exposure to morphine decreases the magnitude of PSD-95, nNOS, the phosphorylation of CREB(Serine-133), and LTD expression in hippocampal CA1 subregion of young offspring (e.g., P14).
Negative_regulation (magnitude) of PSD-95 associated with depression and morphine
12) Confidence 0.35 Published 2006 Journal Hippocampus Section Abstract Doc Link 16598705 Disease Relevance 0.27 Pain Relevance 0.93
Caspace 1, D2 dopamine receptor, GABA-A alpha1 subunit, GRIA 1/3/4, Galphai2, PSD-95 and CREB were down-regulated in the NAc shell with morphine administration.
Negative_regulation (down-regulated) of PSD-95 in shell associated with nucleus accumbens, gaba, dopamine receptor and morphine
13) Confidence 0.28 Published 2004 Journal Neuroscience Section Abstract Doc Link 15183518 Disease Relevance 0.09 Pain Relevance 1.23
Specifically, GABA-A alpha1 subunit, GRIA1 subunit and PSD-95 mRNAs were decreased in the shell but increased in the core following morphine administration.
Negative_regulation (decreased) of PSD-95 in shell associated with gaba and morphine
14) Confidence 0.20 Published 2004 Journal Neuroscience Section Abstract Doc Link 15183518 Disease Relevance 0.09 Pain Relevance 1.22
To address the role of PSD-95/SAP90 in chronic pain, the present study investigated the effect of the deficiency of PSD-95/SAP90 on nerve injury-induced neuropathic pain.
Spec (investigated) Negative_regulation (deficiency) of SAP90 in nerve associated with nervous system injury, lasting pain and neuropathic pain
15) Confidence 0.19 Published 2001 Journal Neuroreport Section Abstract Doc Link 11711866 Disease Relevance 0.79 Pain Relevance 0.74
Knockdown of PSD-95/SAP90 delays the development of neuropathic pain in rats.
Negative_regulation (Knockdown) of SAP90 associated with neuralgia and neuropathic pain
16) Confidence 0.19 Published 2001 Journal Neuroreport Section Title Doc Link 11711866 Disease Relevance 0.78 Pain Relevance 1.06
When FLX treatment was withdrawn for 90 days in those LH-FLX animals in which reversion of despair had been observed at day 25, recurrence of despaired behavior was found accompanied by decreased SYN, PSD-95, and NFL labelings.
Negative_regulation (decreased) of PSD-95 associated with recurrence and fluoxetine
17) Confidence 0.09 Published 2008 Journal Neuropsychopharmacology Section Abstract Doc Link 17955054 Disease Relevance 0.23 Pain Relevance 0.79
Whereas LH animals treated 21 days with saline (LH-S group) displayed diminished SYN and PSD-95 immunostainings in the CA3 but not in the DG, chronic treatment with FLX not only reversed the despaired behavior induced by exposure to LH paradigm, but also fully recovered SYN and PSD-95 labeling to control values.
Negative_regulation (recovered) of PSD-95 associated with fluoxetine
18) Confidence 0.09 Published 2008 Journal Neuropsychopharmacology Section Abstract Doc Link 17955054 Disease Relevance 0.28 Pain Relevance 0.86
Memory loss in response to MDMA is previously reported to be caused by prevented learning specific increase in NMDA NR1 expression and Ca2+/calmodulin-dependent protein kinase II (CaMKII) posphorylation by reduced scaffolding postsynaptic density protein PSD-95 levels, instead of direct effects by reduced 5HT activity itself [50,51].
Negative_regulation (reduced) of protein PSD-95 associated with 5ht and amnesia
19) Confidence 0.06 Published 2008 Journal BMC Neurosci Section Body Doc Link PMC2358913 Disease Relevance 0.34 Pain Relevance 0.33
Whereas LH animals treated 21 days with saline (LH-S group) displayed diminished SYN and PSD-95 immunostainings in the CA3 but not in the DG, chronic treatment with FLX not only reversed the despaired behavior induced by exposure to LH paradigm, but also fully recovered SYN and PSD-95 labeling to control values.
Negative_regulation (diminished) of PSD-95 associated with fluoxetine
20) Confidence 0.03 Published 2008 Journal Neuropsychopharmacology Section Abstract Doc Link 17955054 Disease Relevance 0.28 Pain Relevance 0.78

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