INT97108

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Context Info
Confidence 0.73
First Reported 2001
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 5
Total Number 5
Disease Relevance 2.47
Pain Relevance 1.70

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (IL2) extracellular region (IL2) cell adhesion (IL2)
cell-cell signaling (IL2)
Anatomy Link Frequency
brain 1
IL2R 1
IL2 (Homo sapiens)
Pain Link Frequency Relevance Heat
cytokine 30 99.36 Very High Very High Very High
Morphine 12 99.26 Very High Very High Very High
withdrawal 3 98.98 Very High Very High Very High
opiate 1 75.00 Quite High
Inflammation 17 66.48 Quite High
Pain 4 53.92 Quite High
pruritus 4 5.00 Very Low Very Low Very Low
Paracetamol 3 5.00 Very Low Very Low Very Low
Inflammatory response 2 5.00 Very Low Very Low Very Low
Antihistamine 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Immunodeficiency 15 97.96 Very High Very High Very High
Death 3 90.64 High High
Agammaglobulinemia 2 88.32 High High
Disease 23 86.76 High High
Diphtheria 7 83.24 Quite High
Anaerobic Bacterial Infections 2 78.40 Quite High
Neurological Disease 1 70.64 Quite High
INFLAMMATION 20 66.48 Quite High
Necrosis 2 62.84 Quite High
Cancer 11 62.48 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
History of IL2, IL2R, and anti-Tac
Phosphorylation (History) of IL2 in IL2R
1) Confidence 0.73 Published 2010 Journal Cancer management and research Section Body Doc Link PMC3004568 Disease Relevance 0.32 Pain Relevance 0.03
Here, a long-acting form of IL-2, PEG-IL-2, was given for 12-18 months to 15 randomly chosen CVID subjects, in comparison to 39 CVID subjects who served as controls.
Phosphorylation (form) of IL-2 associated with immunodeficiency
2) Confidence 0.60 Published 2001 Journal Clin. Immunol. Section Abstract Doc Link 11465947 Disease Relevance 0.94 Pain Relevance 0.05
Whereas chronic morphine treatment (48 h after implantation of 75 mg morphine pellets) and withdrawal from morphine (10-15 min after an i.p. injection of 1mg/kg of naltroxone 48 h after implantation of 75 mg morphine pellets) did not alter blood-to-brain transport of IL-1alpha or TNF-alpha, both the chronic morphine treatment and withdrawal from morphine groups had increased blood-to-brain transport of IL-2.
Phosphorylation (transport) of IL-2 in brain associated with withdrawal and morphine
3) Confidence 0.37 Published 2008 Journal Brain Behav. Immun. Section Abstract Doc Link 18502094 Disease Relevance 0.20 Pain Relevance 1.41
Here, a long-acting form of IL-2, PEG-IL-2, was given for 12-18 months to 15 randomly chosen CVID subjects, in comparison to 39 CVID subjects who served as controls.
Phosphorylation (form) of PEG-IL-2 associated with immunodeficiency
4) Confidence 0.26 Published 2001 Journal Clin. Immunol. Section Abstract Doc Link 11465947 Disease Relevance 0.95 Pain Relevance 0.05
The concentration of IL-2, IL-4, IL-6, IL-10, TNF-?
Phosphorylation (concentration) of IL-2
5) Confidence 0.06 Published 2008 Journal BMC Immunol Section Body Doc Link PMC2374764 Disease Relevance 0.07 Pain Relevance 0.16

General Comments

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