INT97126

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Context Info
Confidence 0.40
First Reported 2001
Last Reported 2010
Negated 1
Speculated 2
Reported most in Abstract
Documents 9
Total Number 11
Disease Relevance 8.15
Pain Relevance 3.60

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleoplasm (CASP3) mitochondrion (CASP3) cytoplasm (CASP3)
cytosol (CASP3) peptidase activity (CASP3) nucleolus (CASP3)
Anatomy Link Frequency
poly 1
HL-60 1
Caco-2 1
neutrophils 1
CASP3 (Homo sapiens)
Pain Link Frequency Relevance Heat
qutenza 36 99.84 Very High Very High Very High
aspirin 24 99.20 Very High Very High Very High
Paracetamol 12 99.10 Very High Very High Very High
Inflammation 48 96.32 Very High Very High Very High
cINOD 16 90.16 High High
metalloproteinase 3 87.28 High High
COX-2 inhibitor 4 84.64 Quite High
chemokine 2 82.08 Quite High
Inflammatory response 1 78.80 Quite High
rheumatoid arthritis 20 43.88 Quite Low
Disease Link Frequency Relevance Heat
Apoptosis 135 100.00 Very High Very High Very High
Cervical Cancer 14 99.60 Very High Very High Very High
Leukemia 14 98.36 Very High Very High Very High
INFLAMMATION 60 96.32 Very High Very High Very High
Death 12 94.00 High High
Hepatocellular Cancer 10 92.72 High High
Cancer 222 92.56 High High
Disease 13 91.72 High High
Injury 13 90.36 High High
Familial Adenomatous Polyposis 8 87.92 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In the study, effect of racemic mixtures and enantiomers of 2-arylpropionic acid derivatives: ketoprofen, flurbiprofen (FBP), and (+)-S-naproxen and 2-arylbutyric acid: indobufen on apoptosis activation via caspase-3 and phosphatidylserine (PS) translocation (annexin-V binding) in human neutrophils in vitro has been investigated.
Spec (investigated) Regulation (effect) of caspase-3 in neutrophils associated with apoptosis
1) Confidence 0.40 Published 2008 Journal Chirality Section Abstract Doc Link 18092300 Disease Relevance 1.12 Pain Relevance 0.36
We identified the regulation of apoptosis-responsive genes, bcl-2, caspase-3 and p53 after combined treatment.
Regulation (regulation) of caspase-3 associated with apoptosis
2) Confidence 0.32 Published 2003 Journal Cancer Lett. Section Abstract Doc Link 12490308 Disease Relevance 0.68 Pain Relevance 0.43
The combined treatment of aspirin and radiation induces apoptosis by the regulation of bcl-2 and caspase-3 in human cervical cancer cell.
Regulation (regulation) of caspase-3 associated with aspirin, cervical cancer and apoptosis
3) Confidence 0.32 Published 2003 Journal Cancer Lett. Section Title Doc Link 12490308 Disease Relevance 0.75 Pain Relevance 0.52
Involvement of Bax, Bcl-2, Ca2+ and caspase-3 in capsaicin-induced apoptosis of human leukemia HL-60 cells.
Regulation (Involvement) of caspase-3 in HL-60 associated with leukemia, qutenza and apoptosis
4) Confidence 0.23 Published 2006 Journal Anticancer Res. Section Title Doc Link 16827131 Disease Relevance 0.67 Pain Relevance 0.73
In an effort to further investigate the mechanism by which non-metabolized acetaminophen induces apoptosis, we have now examined the roles of caspase-3, the DNA fragmentation factor, and the poly(ADP-ribose) polymerase-1-regulated Ca2+ and Mg2+-dependent endonuclease DNAS1L3 in the induction of such death process.
Spec (examined) Regulation (roles) of caspase-3 in poly associated with paracetamol, apoptosis and death
5) Confidence 0.18 Published 2004 Journal Basic Clin. Pharmacol. Toxicol. Section Abstract Doc Link 14725611 Disease Relevance 0.60 Pain Relevance 0.38
Our results indicated that the capsaicin-induced apoptosis in HepG2 cells may result from the elevation of intracellular Ca2+ production, ROS, disruption of alpha psi(m), regulation of Bcl-2 family protein expression and caspase-3 activity.
Regulation (regulation) of caspase-3 associated with qutenza and apoptosis
6) Confidence 0.13 Published 2009 Journal Anticancer Res. Section Abstract Doc Link 19331147 Disease Relevance 0.32 Pain Relevance 0.73
A clear positive correlation between COX-2 expression and inhibition of apoptosis has been established, associated with increased PGE2 levels resulting in modulation of pro- and anti-apoptotic factors (e.g., bcl-2, MAKs/ras, caspase-3, Par-4).
Regulation (modulation) of caspase-3 associated with apoptosis
7) Confidence 0.09 Published 2001 Journal J. Cancer Res. Clin. Oncol. Section Abstract Doc Link 11469677 Disease Relevance 1.04 Pain Relevance 0.17
Therefore, induction of apoptosis by triptolide was dependent on the caspase-3 pathway.
Regulation (dependent) of caspase-3 associated with apoptosis
8) Confidence 0.09 Published 2004 Journal BMC Pharmacol Section Body Doc Link PMC373449 Disease Relevance 0.90 Pain Relevance 0.05
Effect of PTL at various concentrations on caspase-9 and caspase-3 expression
Regulation (concentrations) of caspase-3
9) Confidence 0.05 Published 2010 Journal J Exp Clin Cancer Res Section Body Doc Link PMC2924280 Disease Relevance 0.52 Pain Relevance 0
No significant alteration in pro-caspase 3 or beta-catenin expression was found in HCA7, LS174, or Caco-2 cells treated with sulindac sulfone.
Neg (No) Regulation (alteration) of pro-caspase 3 in Caco-2
10) Confidence 0.01 Published 2005 Journal Ann. N. Y. Acad. Sci. Section Abstract Doc Link 16382042 Disease Relevance 0.48 Pain Relevance 0.07
Antiproliferative effects of diosgenin are mediated through cell-cycle arrest, disruption of Ca2+ homeostasis, activation of p53, release of apoptosis-inducing factor, and modulation of caspase-3 activity.
Regulation (modulation) of caspase-3 associated with apoptosis
11) Confidence 0.01 Published 2008 Journal Pharm Res Section Body Doc Link PMC2515569 Disease Relevance 1.06 Pain Relevance 0.17

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