INT97128

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Context Info
Confidence 0.80
First Reported 2001
Last Reported 2010
Negated 0
Speculated 3
Reported most in Body
Documents 32
Total Number 34
Disease Relevance 21.75
Pain Relevance 4.02

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (SPP1) extracellular region (SPP1) cell adhesion (SPP1)
cytoplasm (SPP1)
Anatomy Link Frequency
epithelial cells 4
coronary artery 2
monocytes 2
tendons 2
brain 2
SPP1 (Homo sapiens)
Pain Link Frequency Relevance Heat
fibrosis 648 99.84 Very High Very High Very High
metalloproteinase 4 99.44 Very High Very High Very High
cytokine 60 97.56 Very High Very High Very High
Pain 53 94.76 High High
pulpitis 1 91.32 High High
Inflammation 78 85.52 High High
Acupuncture 61 85.04 High High
Angina 10 83.68 Quite High
Central nervous system 48 81.60 Quite High
Inflammatory response 7 78.56 Quite High
Disease Link Frequency Relevance Heat
Adhesions 89 100.00 Very High Very High Very High
Cancer 331 99.92 Very High Very High Very High
Pulmonary Fibrosis 585 99.84 Very High Very High Very High
Calcification 11 99.52 Very High Very High Very High
Metastasis 248 98.64 Very High Very High Very High
Cardiovascular Disease 11 98.28 Very High Very High Very High
Disease 219 98.04 Very High Very High Very High
Coronary Artery Disease 4 98.04 Very High Very High Very High
Diabetes Mellitus 16 97.80 Very High Very High Very High
Tendinopathy 6 97.72 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
To examine the involvement of osteopontin (OPN), a potent regulator of calcium deposition on connective tissues, localization and expression of OPN protein and messenger (m)RNA were investigated in human tissue samples of calcified rotator cuff tendons.
Spec (investigated) Localization (localization) of OPN in tendons associated with calcification
1) Confidence 0.80 Published 2001 Journal Virchows Arch. Section Abstract Doc Link 11469694 Disease Relevance 0.36 Pain Relevance 0.09
Immunohistochemical localization of osteopontin in human pulp stones.
Localization (localization) of osteopontin
2) Confidence 0.80 Published 2001 Journal J Endod Section Title Doc Link 11485265 Disease Relevance 0.33 Pain Relevance 0.09
Our results provide a potential mechanism by which osteopontin secreted from epithelial cells exerts its profibrotic effects through direct signaling on fibroblasts and epithelial cells.
Localization (secreted) of osteopontin in fibroblasts
3) Confidence 0.79 Published 2005 Journal PLoS Medicine Section Body Doc Link PMC1198037 Disease Relevance 0.55 Pain Relevance 0.20
As illustrated in Figure 3A–3C, osteopontin was localized primarily in alveolar epithelial cells that exhibited an intense cytoplasmic staining in IPF lungs.
Localization (localized) of osteopontin in lungs associated with fibrosis
4) Confidence 0.79 Published 2005 Journal PLoS Medicine Section Body Doc Link PMC1198037 Disease Relevance 0.77 Pain Relevance 0.39
This is also supported by the colocalization of MMP-7 and osteopontin in IPF epithelial cells, and by the computational relationship of the expression levels of osteopontin and MMP-7.
Localization (colocalization) of osteopontin in epithelial cells associated with fibrosis
5) Confidence 0.79 Published 2005 Journal PLoS Medicine Section Body Doc Link PMC1198037 Disease Relevance 0.71 Pain Relevance 0.33
Localization and expression of osteopontin in the rotator cuff tendons in patients with calcifying tendinitis.
Localization (Localization) of osteopontin in tendons associated with tendinopathy
6) Confidence 0.75 Published 2001 Journal Virchows Arch. Section Title Doc Link 11469694 Disease Relevance 0.43 Pain Relevance 0.15
Similarly, osteopontin is cleaved and activated by MMP-7 [31], and we observe that MMP-7 is induced by osteopontin in epithelial cells, suggesting that this positive feedback mechanism is also applicable to osteopontin and MMP-7.
Localization (cleaved) of osteopontin in epithelial cells
7) Confidence 0.74 Published 2005 Journal PLoS Medicine Section Body Doc Link PMC1198037 Disease Relevance 0.81 Pain Relevance 0.37
Interestingly, osteopontin was colocalized with MMP-7 in alveolar epithelial cells of IPF lungs, and application of the weakest link models to microarray data suggested that the genes of both interacted to affect the IPF phenotype.
Localization (colocalized) of osteopontin in epithelial cells associated with fibrosis
8) Confidence 0.74 Published 2005 Journal PLoS Medicine Section Body Doc Link PMC1198037 Disease Relevance 0.49 Pain Relevance 0.22
SPP1 (osteopontin), a secreted, integrin-binding glycoprotein with adhesive properties, has been shown to be correlated with metastasis to the bone and with poor prognosis in various cancers and is highly upregulated in all the metastatic samples in our study.
Localization (secreted) of osteopontin associated with cancer and metastasis
9) Confidence 0.73 Published 2007 Journal BMC Cancer Section Body Doc Link PMC1865555 Disease Relevance 0.95 Pain Relevance 0
In agreement with this, the secreted phosphoprotein and cell adhesion molecule osteopontin (SPP1) is one of the most highly upregulated transcripts in our metastatic samples.
Localization (secreted) of osteopontin associated with adhesions
10) Confidence 0.73 Published 2007 Journal BMC Cancer Section Body Doc Link PMC1865555 Disease Relevance 1.22 Pain Relevance 0
SPP1 (osteopontin), a secreted, integrin-binding glycoprotein with adhesive properties, has been shown to be correlated with metastasis to the bone and with poor prognosis in various cancers and is highly upregulated in all the metastatic samples in our study.
Localization (secreted) of SPP1 associated with cancer and metastasis
11) Confidence 0.73 Published 2007 Journal BMC Cancer Section Body Doc Link PMC1865555 Disease Relevance 0.95 Pain Relevance 0
In agreement with this, the secreted phosphoprotein and cell adhesion molecule osteopontin (SPP1) is one of the most highly upregulated transcripts in our metastatic samples.
Localization (secreted) of SPP1 associated with adhesions
12) Confidence 0.73 Published 2007 Journal BMC Cancer Section Body Doc Link PMC1865555 Disease Relevance 1.22 Pain Relevance 0
Immunohistochemistry demonstrated that OPN was localized in cells surrounding the calcified area.
Localization (localized) of OPN
13) Confidence 0.70 Published 2001 Journal Virchows Arch. Section Abstract Doc Link 11469694 Disease Relevance 0.34 Pain Relevance 0.09
Osteopontin (also termed secreted phosphoprotein 1) is a phosphorylated acidic glycoprotein that contains an Arg-Gly-Asp motif that binds to the integrin family of adhesion molecules [8].
Localization (secreted) of Osteopontin associated with adhesions
14) Confidence 0.70 Published 2005 Journal PLoS Medicine Section Body Doc Link PMC1198037 Disease Relevance 1.34 Pain Relevance 0.26
Our results provide a potential mechanism by which osteopontin secreted from the alveolar epithelium may exert a profibrotic effect in IPF lungs and highlight osteopontin as a potential target for therapeutic intervention in this incurable disease.



Localization (secreted) of osteopontin in lungs associated with fibrosis and disease
15) Confidence 0.70 Published 2005 Journal PLoS Medicine Section Abstract Doc Link PMC1198037 Disease Relevance 0.50 Pain Relevance 0.20
Two multiplex PCR were used to detect Escherichia coli, Salmonella spp., and Shigella spp.
Localization (detect) of spp
16) Confidence 0.68 Published 2007 Journal Ann Clin Microbiol Antimicrob Section Abstract Doc Link PMC2246149 Disease Relevance 0.50 Pain Relevance 0
Two multiplex PCR were used to detect Escherichia coli, Salmonella spp., and Shigella spp.
Localization (detect) of spp
17) Confidence 0.68 Published 2007 Journal Ann Clin Microbiol Antimicrob Section Abstract Doc Link PMC2246149 Disease Relevance 0.49 Pain Relevance 0
AIMS: Levels of the secreted glycophosphoprotein osteopontin (OPN) have been associated with the presence and extent of coronary artery disease (CAD).
Localization (secreted) of osteopontin in coronary artery associated with coronary artery disease
18) Confidence 0.63 Published 2006 Journal Eur. Heart J. Section Abstract Doc Link 16421174 Disease Relevance 0.27 Pain Relevance 0.16
Osteopontin (also termed secreted phosphoprotein 1) is a phosphorylated acidic glycoprotein that contains an Arg-Gly-Asp motif that binds to the integrin family of adhesion molecules [8].
Localization (secreted) of phosphoprotein 1 associated with adhesions
19) Confidence 0.61 Published 2005 Journal PLoS Medicine Section Body Doc Link PMC1198037 Disease Relevance 1.34 Pain Relevance 0.26
OPN is a secreted protein responsible for stimulating various signaling pathways, including those promoting survival and metastases under hypoxia [25].
Localization (secreted) of OPN associated with hypoxia and metastasis
20) Confidence 0.56 Published 2009 Journal J Transl Med Section Body Doc Link PMC2796647 Disease Relevance 0.94 Pain Relevance 0.04

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