INT97130

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Context Info
Confidence 0.35
First Reported 2001
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 5
Total Number 5
Disease Relevance 1.96
Pain Relevance 0.63

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (CD40) extracellular region (CD40) plasma membrane (CD40)
enzyme binding (CD40) protein complex assembly (CD40) signal transducer activity (CD40)
Anatomy Link Frequency
PDL-1 1
CD86 1
B-cell 1
dendritic cells 1
CD40 (Homo sapiens)
Pain Link Frequency Relevance Heat
tolerance 7 100.00 Very High Very High Very High
Inflammation 54 91.92 High High
rheumatoid arthritis 58 91.40 High High
psoriasis 68 76.32 Quite High
cytokine 33 62.32 Quite High
chemokine 10 56.48 Quite High
Infliximab 15 5.00 Very Low Very Low Very Low
methotrexate 14 5.00 Very Low Very Low Very Low
Etanercept 13 5.00 Very Low Very Low Very Low
Chronic pancreatitis 10 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Adhesions 9 98.96 Very High Very High Very High
INFLAMMATION 55 91.92 High High
Rheumatoid Arthritis 58 91.40 High High
Autoimmune Disease 12 90.88 High High
Adenocarcinoma 90 84.36 Quite High
Disease 50 79.88 Quite High
Psoriasis 76 76.32 Quite High
Immunization 1 75.96 Quite High
Infection 9 75.32 Quite High
Lymphatic System Cancer 13 62.64 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In distinction to drug-free maturing dendritic cells, 2.5 micromol/L sulfasalazine upregulated the levels of CD14 and CD68 and downregulated the levels of CD40, CD80, and CD83 (for all CD markers, p<0.03 for difference between measurements in the absence and the presence of sulfasalazine).
Negative_regulation (downregulated) of CD40 in dendritic cells
1) Confidence 0.35 Published 2001 Journal Croat. Med. J. Section Body Doc Link 11471196 Disease Relevance 0 Pain Relevance 0
The TLR3 ligation induced a MDC maturation profile with upregulation of the markers; CD40, CD83, CD86, CCR7, PDL-1, and downregulation of ICOSL, B7H3, and CCR5 (Figure 9).
Negative_regulation (downregulation) of CD40 in PDL-1
2) Confidence 0.22 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2955544 Disease Relevance 0.31 Pain Relevance 0.03
The loss of tolerance model due to CD40–CD40L activation signals
Negative_regulation (loss) of CD40 associated with tolerance
3) Confidence 0.21 Published 2006 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC1661661 Disease Relevance 0.85 Pain Relevance 0.45
Indeed, antagonistic antibodies to CD22 could provoke downregulation of the BCR (by SHP-1 [Src homology phosphatase-1] recruitment) and inhibiting T- and B-cell crosstalk by downregulation of the CD40 pathway [15,18,19].
Negative_regulation (downregulation) of CD40 in B-cell
4) Confidence 0.21 Published 2006 Journal Arthritis Res Ther Section Body Doc Link PMC1779377 Disease Relevance 0.39 Pain Relevance 0
In addition, the LC also acquires a number of cell surface receptor markers such as CD80, CD86, CD40, CD83, and intercellular adhesion molecule (ICAM) 1.
Negative_regulation (number) of CD40 in CD86 associated with adhesions
5) Confidence 0.17 Published 2008 Journal Indian Journal of Pharmacology Section Body Doc Link PMC2792605 Disease Relevance 0.43 Pain Relevance 0.15

General Comments

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