INT97131

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Context Info
Confidence 0.67
First Reported 2001
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 25
Total Number 25
Disease Relevance 12.03
Pain Relevance 4.21

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (CD14) extracellular region (CD14) plasma membrane (CD14)
Anatomy Link Frequency
DCs 2
saliva 2
T cells 2
macrophages 1
plasma 1
CD14 (Homo sapiens)
Pain Link Frequency Relevance Heat
psoriasis 82 99.84 Very High Very High Very High
Inflammation 266 99.40 Very High Very High Very High
Arthritis 302 99.36 Very High Very High Very High
rheumatoid arthritis 184 98.96 Very High Very High Very High
endometriosis 21 97.68 Very High Very High Very High
spinal inflammation 62 96.12 Very High Very High Very High
cytokine 160 95.72 Very High Very High Very High
chemokine 52 95.16 Very High Very High Very High
ischemia 3 95.12 Very High Very High Very High
Enkephalin 15 93.36 High High
Disease Link Frequency Relevance Heat
Psoriasis 93 99.84 Very High Very High Very High
Oral Lichen Planus 12 99.84 Very High Very High Very High
Burning Mouth Syndrome 12 99.78 Very High Very High Very High
Sepsis 91 99.68 Very High Very High Very High
Disease 177 99.44 Very High Very High Very High
Arthritis 36 99.40 Very High Very High Very High
Seronegative Spondarthritis 267 99.36 Very High Very High Very High
Endometriosis 12 99.12 Very High Very High Very High
Rheumatoid Arthritis 203 98.96 Very High Very High Very High
Endometriosis (extended) 38 97.68 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Our results suggest that the levels of sCD14 and sTLR-2 in UWS were upregulated in OLP and BMS respectively.
Positive_regulation (upregulated) of CD14 in UWS associated with oral lichen planus and burning mouth syndrome
1) Confidence 0.67 Published 2008 Journal Clin. Immunol. Section Abstract Doc Link 17916440 Disease Relevance 1.21 Pain Relevance 0.08
In addition, oral epithelial cells in the saliva of patients with OLP and BMS exhibited elevated levels of CD14 mRNA and decreased levels of TLR-2 mRNA.
Positive_regulation (elevated) of CD14 in saliva associated with oral lichen planus and burning mouth syndrome
2) Confidence 0.66 Published 2008 Journal Clin. Immunol. Section Abstract Doc Link 17916440 Disease Relevance 1.17 Pain Relevance 0.07
In distinction to drug-free maturing dendritic cells, 2.5 micromol/L sulfasalazine upregulated the levels of CD14 and CD68 and downregulated the levels of CD40, CD80, and CD83 (for all CD markers, p<0.03 for difference between measurements in the absence and the presence of sulfasalazine).
Positive_regulation (upregulated) of CD14 in dendritic cells
3) Confidence 0.56 Published 2001 Journal Croat. Med. J. Section Body Doc Link 11471196 Disease Relevance 0 Pain Relevance 0
Our study is complementary to a study by Moriyama et al [35] who found that animals ventilated with high VT (20 ml/kg) for 4 hours had increased expression of receptor CD14 mRNA and protein in the absence of LPS stimulation.
Positive_regulation (increased) of CD14
4) Confidence 0.49 Published 2010 Journal Respir Res Section Body Doc Link PMC2841148 Disease Relevance 0.34 Pain Relevance 0.14
Flow cytometry analysis revealed that the adherent fibroblast-like cells were consistently positive for CD29, CD44, CD105, and CD166, and were negative for CD14, CD34, and CD45.
Positive_regulation (negative) of CD14 in fibroblast
5) Confidence 0.44 Published 2007 Journal J. Cell. Physiol. Section Abstract Doc Link 17171634 Disease Relevance 0.61 Pain Relevance 0.07
A recent study presented a local upregulation of CD14 and CD163 in ovarian endometriotic lesions [46].
Positive_regulation (upregulation) of CD14 associated with endometriosis
6) Confidence 0.43 Published 2008 Journal Reprod Biol Endocrinol Section Body Doc Link PMC2543020 Disease Relevance 1.07 Pain Relevance 0.27
For example, although CD14+16+ cells are increased in psoriasis, inflammatory arthritis and sepsis, the differentiation fate of these cells is determined by cytokines and chemokines in the local microenvironment.
Positive_regulation (increased) of CD14+ associated with chemokine, psoriasis, inflammation, sepsis, cytokine and arthritis
7) Confidence 0.40 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2875642 Disease Relevance 1.04 Pain Relevance 0.64
After three-day culture in plain media, the percentage of CD14+CD16+ increased in both HC and PsA samples (0.32 to 5.94 for Figure 6(a) vs. 6(c), and 2.50 to 3.38 for Figure 6(b) vs. 6(e)), similar to the result after PBMC were cultured in OC-promoting conditions (Figure 2(b)).
Positive_regulation (increased) of CD14+ associated with arthritis
8) Confidence 0.40 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2875642 Disease Relevance 0.59 Pain Relevance 0.27
blocks CD16 upregulation on some CD14+ cells, resulting in two distinct CD14+ populations, CD14+CD16+ and CD14+CD16int (indicated by vertical arrows in Figures 6(d) and 6(f)).
Positive_regulation (upregulation) of CD14+
9) Confidence 0.40 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2875642 Disease Relevance 0.47 Pain Relevance 0.21
increased the expression of HLA-DR, particularly on CD14HIGH cells (CD14HIGH: + 263%; CD14LOW: + 87%) (Figure 7).
Positive_regulation (increased) of CD14HIGH
10) Confidence 0.34 Published 2010 Journal Crit Care Section Body Doc Link PMC2887183 Disease Relevance 0 Pain Relevance 0.26
increased the expression of HLA-DR, particularly on CD14HIGH cells (CD14HIGH: + 263%; CD14LOW: + 87%) (Figure 7).
Positive_regulation (increased) of CD14HIGH
11) Confidence 0.34 Published 2010 Journal Crit Care Section Body Doc Link PMC2887183 Disease Relevance 0 Pain Relevance 0.26
As shown in Figure 8, HLA-DR expression on both CD14HIGH and CD14LOW monocytes was up-regulated by these pathogen-associated molecular patterns (PAMPs), particularly on CD14HIGH cells.
Positive_regulation (regulated) of CD14HIGH in monocytes
12) Confidence 0.34 Published 2010 Journal Crit Care Section Body Doc Link PMC2887183 Disease Relevance 0 Pain Relevance 0.19
Monocytes express higher levels of CD14 than neutrophils.
Positive_regulation (levels) of CD14 in neutrophils
13) Confidence 0.34 Published 2010 Journal Crit Care Section Body Doc Link PMC2887183 Disease Relevance 0.38 Pain Relevance 0.17
In accordance with previous results [29] the CD14+/CD16- and CD14+/CD16+ subpopulations were both present in all RA (n = 7) and healthy (n = 6) PB samples, however marked heterogeneity was observed in the RA SF, with these two CD14/CD16 subpopulations being observed together in only one out of seven SF samples analysed (data not shown).
Positive_regulation (subpopulations) of CD14 associated with rheumatoid arthritis
14) Confidence 0.32 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2945064 Disease Relevance 0.74 Pain Relevance 0.32
Immature monocyte-derived DCs can be subsequently matured with LPS, which determines the upregulation of their antigen-presenting and co-stimulatory molecules, together with higher expression of the integrin CD11c and lack of CD14.
Positive_regulation (lack) of CD14 in DCs
15) Confidence 0.31 Published 2009 Journal PLoS Neglected Tropical Diseases Section Body Doc Link PMC2654967 Disease Relevance 0.34 Pain Relevance 0.03
B mRNA follows a CD14 migratory-like transcription pattern in the brain of rats following intraperitoneal LPS administration [62].
Positive_regulation (follows) of CD14 in brain
16) Confidence 0.30 Published 2005 Journal Crit Care Section Body Doc Link PMC1065096 Disease Relevance 0.26 Pain Relevance 0.21
The HLA-DR downregulation on the CD14LOW subset, which is increased during sepsis [29], was transient and less severe.
Positive_regulation (increased) of CD14LOW associated with sepsis
17) Confidence 0.30 Published 2010 Journal Crit Care Section Body Doc Link PMC2887183 Disease Relevance 0.26 Pain Relevance 0.08
Alternatively, for double staining CD14 and DENV, cells were firstly labelled with PE-labelled antibodies to CD14 (DAKO at dilution 1:100) for 30 minutes 4°C, washed, fixed with 0,5 ml cold 2% paraformaldehyde for 10 minutes and, after centrifugation, membrane permeabilization was carried out with 1 ml 0.1% saponine PBS with FCS and NaN3 and further labelled with Alexa 654 – labelled monoclonal antibody to Dengue for 30 minutes.
Positive_regulation (staining) of CD14 associated with dengue
18) Confidence 0.25 Published 2005 Journal BMC Infect Dis Section Body Doc Link PMC1208887 Disease Relevance 0.30 Pain Relevance 0
To investigate whether sCD14 from autologous serum was crucial for a stronger response of CD4+CD28null T cells to LPS, cells were incubated with a blocking antibody directed against CD14 prior to the addition of LPS.
Positive_regulation (directed) of CD14 in T cells
19) Confidence 0.25 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1297589 Disease Relevance 0.26 Pain Relevance 0.26
Taking these facts together, activated CD4+CD28null T cells produce perforin upon LPS-mediated activation in a CD14-dependent and TLR4-dependent manner.
Positive_regulation (activation) of CD14-dependent in T cells
20) Confidence 0.25 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1297589 Disease Relevance 0.49 Pain Relevance 0.36

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