INT97132

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Context Info
Confidence 0.08
First Reported 2001
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 5
Total Number 9
Disease Relevance 6.54
Pain Relevance 2.76

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (TBK1) plasma membrane (TBK1) cytoplasm (TBK1)
Anatomy Link Frequency
leukocyte 2
cartilage 2
dendritic cells 2
TBK1 (Homo sapiens)
Pain Link Frequency Relevance Heat
Inflammation 425 99.28 Very High Very High Very High
COX-2 inhibitor 17 99.04 Very High Very High Very High
cINOD 177 98.16 Very High Very High Very High
aspirin 50 95.04 Very High Very High Very High
cytokine 61 94.24 High High
ischemia 2 93.20 High High
Arthritis 25 88.20 High High
Osteoarthritis 10 85.00 Quite High
Inflammatory response 20 83.92 Quite High
metalloproteinase 15 80.16 Quite High
Disease Link Frequency Relevance Heat
Cancer 54 99.70 Very High Very High Very High
Apoptosis 18 99.50 Very High Very High Very High
INFLAMMATION 453 99.28 Very High Very High Very High
Cv Unclassified Under Development 3 93.20 High High
Reperfusion Injury 1 92.48 High High
Pressure And Volume Under Development 21 89.72 High High
Enteropathy 5 89.64 High High
Stress 2 89.44 High High
Bursitis 5 88.60 High High
Arthritis 45 88.20 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
At 1.25 micromol/L, sulfasalazine largely inhibited NF-kB activation in dendritic cells.
Negative_regulation (inhibited) of Positive_regulation (activation) of NF-kB in dendritic cells
1) Confidence 0.08 Published 2001 Journal Croat. Med. J. Section Body Doc Link 11471196 Disease Relevance 0 Pain Relevance 0
This herb has been shown to prevent the activation of the transcriptional factor NF-kB and it directly inhibits TNF-?
Negative_regulation (prevent) of Positive_regulation (activation) of NF-kB
2) Confidence 0.06 Published 2010 Journal Surgical Neurology International Section Body Doc Link PMC3011108 Disease Relevance 0.74 Pain Relevance 0.11
These agents inhibit the NF-kB pathway in endothelial cells and block NF-kB activation to inhibit leukocyte recruitment.[114115116] NSAIDs have also been found to inhibit both the COX system and the NF-kB pathway.
Negative_regulation (block) of Positive_regulation (activation) of NF-kB in leukocyte associated with cinod
3) Confidence 0.06 Published 2010 Journal Surgical Neurology International Section Body Doc Link PMC3011108 Disease Relevance 0.90 Pain Relevance 0.70
In vitro inhibition of COX-2 with targeted molecules is thought to promote apoptosis of cancer cells through inhibition of NF-kB activation [20].
Negative_regulation (inhibition) of Positive_regulation (activation) of NF-kB associated with cancer and apoptosis
4) Confidence 0.06 Published 2007 Journal BMC Cancer Section Body Doc Link PMC2234426 Disease Relevance 1.21 Pain Relevance 0.38
Resveratrol shows the anti-inflammatory properties as it suppresses COX-2 by blocking NF-kB activation.
Negative_regulation (blocking) of Positive_regulation (activation) of NF-kB associated with inflammation
5) Confidence 0.04 Published 2010 Journal Surgical Neurology International Section Body Doc Link PMC3011108 Disease Relevance 0.82 Pain Relevance 0.33
Epigallocatechin-3 galate inhibits IL-1–induced proteoglycan release and type 2 collagen degradation in cartilage explants.[44] In human in vitro models, it also suppresses IL-1b and attenuates activation of the transcription factor NF-kB.
Negative_regulation (attenuates) of Positive_regulation (activation) of NF-kB in cartilage
6) Confidence 0.04 Published 2010 Journal Surgical Neurology International Section Body Doc Link PMC3011108 Disease Relevance 0.67 Pain Relevance 0.14
Immunosuppressant drugs also reduce nuclear expression of NF-kB.[397075] Research now indicates that blocking the activation of NF-kB along with other inflammation mediators [Table 2] is the major mechanism for reducing inflammation by natural compounds.


Negative_regulation (blocking) of Positive_regulation (activation) of NF-kB associated with inflammation
7) Confidence 0.04 Published 2010 Journal Surgical Neurology International Section Body Doc Link PMC3011108 Disease Relevance 0.76 Pain Relevance 0.60
It ultimately inhibits the activation of the transcription factor NF-kB by protecting its inhibitor (IkB) from degradation by the proteasome complex (Fig. 2).
Negative_regulation (inhibits) of Positive_regulation (activation) of NF-kB
8) Confidence 0.04 Published 2007 Journal Clin Exp Med Section Body Doc Link PMC2779346 Disease Relevance 0.42 Pain Relevance 0.03
For example, TNFAIP3 displays potent anti-inflammatory properties in a number of different cell types, through the inhibition of NF-kB activation and prevention of TLR-mediated responses [43]–[48].
Negative_regulation (inhibition) of Positive_regulation (activation) of NF-kB associated with inflammation
9) Confidence 0.03 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2654409 Disease Relevance 1.02 Pain Relevance 0.47

General Comments

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