INT97137

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Context Info
Confidence 0.33
First Reported 2001
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 7
Total Number 7
Disease Relevance 3.39
Pain Relevance 0.34

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (CD80) intracellular (CD80) cell-cell signaling (CD80)
Anatomy Link Frequency
blood 6
B-cells 2
dendritic cells 2
T cells 2
CD80 (Homo sapiens)
Pain Link Frequency Relevance Heat
Inflammation 43 97.20 Very High Very High Very High
chemokine 15 86.12 High High
cytokine 38 68.56 Quite High
Central nervous system 7 32.96 Quite Low
Chronic pancreatitis 10 5.00 Very Low Very Low Very Low
agonist 6 5.00 Very Low Very Low Very Low
imagery 5 5.00 Very Low Very Low Very Low
anesthesia 4 5.00 Very Low Very Low Very Low
ketamine 3 5.00 Very Low Very Low Very Low
dexamethasone 3 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Acquired Immune Deficiency Syndrome Or Hiv Infection 101 99.24 Very High Very High Very High
Disease 46 98.84 Very High Very High Very High
Breast Cancer 6 98.08 Very High Very High Very High
Hepatocellular Cancer 1 97.36 Very High Very High Very High
INFLAMMATION 47 97.20 Very High Very High Very High
Adenocarcinoma 90 93.52 High High
Viremia 36 93.12 High High
Infection 162 92.40 High High
Cancer 92 87.96 High High
Leukemia 1 85.20 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In distinction to drug-free maturing dendritic cells, 2.5 micromol/L sulfasalazine upregulated the levels of CD14 and CD68 and downregulated the levels of CD40, CD80, and CD83 (for all CD markers, p<0.03 for difference between measurements in the absence and the presence of sulfasalazine).
Negative_regulation (downregulated) of Gene_expression (levels) of CD80 in dendritic cells
1) Confidence 0.33 Published 2001 Journal Croat. Med. J. Section Body Doc Link 11471196 Disease Relevance 0 Pain Relevance 0
This loss was also demonstrated by decreases in CD80-, 86- and 95-expressing B-cells in these three organs.
Negative_regulation (decreases) of Gene_expression (expressing) of CD80 in B-cells
2) Confidence 0.22 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2695011 Disease Relevance 0.57 Pain Relevance 0.05
However, only 2 of 14 patients' DC showed CD80 expression, while CD83 was negative in all the patients.
Negative_regulation (showed) of Gene_expression (expression) of CD80
3) Confidence 0.17 Published 2010 Journal Clinical and Developmental Immunology Section Body Doc Link PMC3022181 Disease Relevance 0 Pain Relevance 0.09
PolyIC was shown to effectively block HIV replication in DCs in vitro [22], to upregulate CD80 expression on blood mDCs in vivo following tonsillar application (E.
Negative_regulation (upregulate) of Gene_expression (expression) of CD80 in blood associated with acquired immune deficiency syndrome or hiv infection
4) Confidence 0.16 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2943484 Disease Relevance 0.38 Pain Relevance 0.03
The 12-week course ART was effective at reducing blood mDC activation, particularly with respect to CD80, and in animals in the stable group expression of all markers of activation returned to preinfection levels during ART (Figure 3A–C).
Negative_regulation (reducing) of Gene_expression (effective) of CD80 in blood
5) Confidence 0.15 Published 2010 Journal PLoS Pathogens Section Body Doc Link PMC3009592 Disease Relevance 0.83 Pain Relevance 0.04
Furthermore, impaired expression of CD80, CD86, and HLA DR by blood DC in patients with breast cancer and hepatocellular carcinoma, may have contributed to their decreased immunostimulatory capacity [22], [23].
Negative_regulation (impaired) of Gene_expression (expression) of CD80 in blood associated with hepatocellular cancer and breast cancer
6) Confidence 0.12 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2955544 Disease Relevance 1.20 Pain Relevance 0.07
The cumulative response of activating the STAT3 pathway in the immune system is anti-inflammatory by a combination of suppressing macrophage activation [22,23], reducing the cellular cytotoxicity of natural killer cells and neutrophils, reducing the expression of major histocompatibility complex (MHC) II, CD80, CD86, and IL-12 in dendritic cells rendering them unable to stimulate T cells and generate antitumor immunity [15] and enhancing Treg activity [20].
Neg (unable) Negative_regulation (reducing) of Gene_expression (expression) of CD80 in T cells associated with inflammation
7) Confidence 0.10 Published 2009 Journal J Transl Med Section Body Doc Link PMC2777138 Disease Relevance 0.41 Pain Relevance 0.05

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