INT97138

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Context Info
Confidence 0.48
First Reported 2001
Last Reported 2010
Negated 4
Speculated 2
Reported most in Body
Documents 17
Total Number 19
Disease Relevance 9.07
Pain Relevance 3.35

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (CD14) extracellular region (CD14) plasma membrane (CD14)
Anatomy Link Frequency
T cells 8
ovary 4
monocytes 3
neutrophils 3
macrophages 2
CD14 (Homo sapiens)
Pain Link Frequency Relevance Heat
Potency 2 99.72 Very High Very High Very High
agonist 24 99.40 Very High Very High Very High
Morphine 6 99.34 Very High Very High Very High
Inflammation 245 99.30 Very High Very High Very High
rheumatoid arthritis 184 98.28 Very High Very High Very High
cytokine 161 97.60 Very High Very High Very High
anesthesia 37 93.72 High High
Inflammatory response 36 93.20 High High
spinal inflammation 124 83.44 Quite High
corticosteroid 28 79.28 Quite High
Disease Link Frequency Relevance Heat
INFLAMMATION 284 99.30 Very High Very High Very High
Acne 11 99.04 Very High Very High Very High
Rheumatoid Arthritis 203 98.28 Very High Very High Very High
Nicotine Addiction 146 97.68 Very High Very High Very High
Pulmonary Disease 134 97.40 Very High Very High Very High
Sprains And Strains 30 97.20 Very High Very High Very High
Bronchiectasis 1 95.68 Very High Very High Very High
Targeted Disruption 4 95.52 Very High Very High Very High
Asthma 112 92.32 High High
Infection 79 92.16 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In this study, we investigated the effects of morphine and nitric oxide on CD14 expression and activator protein 1 activation in human blood monocytes and neutrophils as well as the leukocyte cell line HL-60.
Spec (investigated) Positive_regulation (activation) of Gene_expression (expression) of CD14 in monocytes associated with morphine
1) Confidence 0.48 Published 2007 Journal Eur J Anaesthesiol Section Abstract Doc Link 17583593 Disease Relevance 0 Pain Relevance 0.21
Our study is complementary to a study by Moriyama et al [35] who found that animals ventilated with high VT (20 ml/kg) for 4 hours had increased expression of receptor CD14 mRNA and protein in the absence of LPS stimulation.
Positive_regulation (increased) of Gene_expression (expression) of CD14
2) Confidence 0.45 Published 2010 Journal Respir Res Section Body Doc Link PMC2841148 Disease Relevance 0.34 Pain Relevance 0.14
In contrast Lauener et al. demonstrated a significantly increased expression of CD14 and TLR2 on blood cells of farmers' children compared to non-farmers' children [31].
Positive_regulation (increased) of Gene_expression (expression) of CD14 in blood cells
3) Confidence 0.38 Published 2005 Journal Respir Res Section Body Doc Link PMC1187924 Disease Relevance 1.28 Pain Relevance 0.03
In distinction to drug-free maturing dendritic cells, 2.5 micromol/L sulfasalazine upregulated the levels of CD14 and CD68 and downregulated the levels of CD40, CD80, and CD83 (for all CD markers, p<0.03 for difference between measurements in the absence and the presence of sulfasalazine).
Positive_regulation (upregulated) of Gene_expression (levels) of CD14 in dendritic cells
4) Confidence 0.38 Published 2001 Journal Croat. Med. J. Section Body Doc Link 11471196 Disease Relevance 0 Pain Relevance 0
There was no effect of LPS stimulation on the surface expression of CD14 and TLR4 in all groups.
Positive_regulation (stimulation) of Gene_expression (expression) of CD14
5) Confidence 0.35 Published 2005 Journal Respir Res Section Body Doc Link PMC1187924 Disease Relevance 0.99 Pain Relevance 0
for 24 hours increased the expression of TLR4 and TLR2, but not of CD14 on CD4+CD28null T cells (from 9.2 ± 25.8% to 26.6 ± 27.7% for TLR4, P < 0.001 and from 1.1 ± 3.1% to 2.4 ± 4.1% for TLR2, P = 0.008; Figure 6a).
Neg (not) Positive_regulation (increased) of Gene_expression (expression) of CD14 in T cells
6) Confidence 0.35 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1297589 Disease Relevance 0.22 Pain Relevance 0.17
This later subpopulation showed a significantly higher expression of the IL-10R than the CD14LOW, which might explain the difference in sensitivity to this cytokine in vitro.
Positive_regulation (higher) of Gene_expression (expression) of CD14LOW associated with cytokine
7) Confidence 0.34 Published 2010 Journal Crit Care Section Body Doc Link PMC2887183 Disease Relevance 0.25 Pain Relevance 0.15
Monocytes express higher levels of CD14 than neutrophils.
Positive_regulation (levels) of Gene_expression (express) of CD14 in neutrophils
8) Confidence 0.34 Published 2010 Journal Crit Care Section Body Doc Link PMC2887183 Disease Relevance 0.38 Pain Relevance 0.17
The percentage of CD14+ macrophages that were positive for CCR9 was higher in RA than in non-RA synovia, being 81 and 66% respectively (as calculated by number of CCR9+/CD14+ cells ÷ number of CD14+ cells × 100 in Table 1).
Positive_regulation (percentage) of Gene_expression (macrophages) of CD14 in macrophages associated with rheumatoid arthritis
9) Confidence 0.28 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2945064 Disease Relevance 1.36 Pain Relevance 0.68
Importantly, there is associated activation of the innate immune response with increased expression of Toll-like receptors 2 and 4 and CD14 [55].
Positive_regulation (increased) of Gene_expression (expression) of CD14
10) Confidence 0.26 Published 2007 Journal Allergy Asthma Clin Immunol Section Body Doc Link PMC2873624 Disease Relevance 1.73 Pain Relevance 0.27
Expression of CD14, TLR4 and TLR2 were neither induced on CD4+CD28+ T cells nor on CD8+ T cells after incubation with TNF-?
Neg (neither) Positive_regulation (induced) of Gene_expression (Expression) of CD14 in T cells
11) Confidence 0.25 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1297589 Disease Relevance 0.22 Pain Relevance 0.15
Expression of CD14, TLR4 and TLR2 were neither induced on CD4+CD28+ T cells nor on CD8+ T cells after incubation with TNF-?
Neg (nor) Positive_regulation (on) of Gene_expression (Expression) of CD14 in T cells
12) Confidence 0.25 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1297589 Disease Relevance 0.22 Pain Relevance 0.15
Expression of CD14, TLR4 and TLR2 were neither induced on CD4+CD28+ T cells nor on CD8+ T cells after incubation with TNF-?
Neg (nor) Positive_regulation (on) of Gene_expression (Expression) of CD14 in T cells
13) Confidence 0.25 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1297589 Disease Relevance 0.22 Pain Relevance 0.15
Acne inflammation may also develop because P. acnes stimulates the expression of TLR 2, 4 and CD14 in human keratinocytes [27].
Positive_regulation (stimulates) of Gene_expression (expression) of CD14 in keratinocytes associated with inflammation and acne
14) Confidence 0.19 Published 2010 Journal Mediators of Inflammation Section Body Doc Link PMC2933899 Disease Relevance 1.18 Pain Relevance 0.49
In this setting, HMB-PP-stimulated but not unstimulated co-cultures produced soluble factors that crossed the separating membrane and down-modulated CD14 as well as induced expression of CD40, CD86, and HLA-DR.
Positive_regulation (induced) of Gene_expression (expression) of CD14 in CD86
15) Confidence 0.18 Published 2009 Journal PLoS Pathogens Section Body Doc Link PMC2637987 Disease Relevance 0 Pain Relevance 0.04
In this study, we investigated the effects of morphine and nitric oxide on CD14 expression and activator protein 1 activation in human blood monocytes and neutrophils as well as the leukocyte cell line HL-60.
Spec (investigated) Positive_regulation (activation) of in neutrophils Gene_expression (expression) of CD14 in monocytes associated with morphine
16) Confidence 0.16 Published 2007 Journal Eur J Anaesthesiol Section Abstract Doc Link 17583593 Disease Relevance 0 Pain Relevance 0.21
MyD88 and CD14 are essential proteins involved in TLR signal transduction and LPS binding; therefore, their expression following insulin infusion was also investigated.
Positive_regulation (following) of Gene_expression (expression) of CD14
17) Confidence 0.16 Published 2008 Journal Diabetes Care Section Body Doc Link PMC2518353 Disease Relevance 0.06 Pain Relevance 0
CD14-deficient cell lines such as Chinese hamster ovary are unresponsive to LPS at high doses, and cell lines that show poor LPS activation can be converted to show high activation when transfected with the CD14 gene [71].
Positive_regulation (transfected) of Gene_expression (transfected) of CD14 in ovary
18) Confidence 0.09 Published 2006 Journal Environ Health Section Body Doc Link PMC1489932 Disease Relevance 0.34 Pain Relevance 0.20
CD14-deficient cell lines such as Chinese hamster ovary are unresponsive to LPS at high doses, and cell lines that show poor LPS activation can be converted to show high activation when transfected with the CD14 gene [71].
Positive_regulation (transfected) of Gene_expression (transfected) of CD14 in ovary
19) Confidence 0.09 Published 2006 Journal Environ Health Section Body Doc Link PMC1489932 Disease Relevance 0.29 Pain Relevance 0.14

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