INT97141

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Context Info
Confidence 0.55
First Reported 2001
Last Reported 2010
Negated 2
Speculated 1
Reported most in Body
Documents 6
Total Number 8
Disease Relevance 2.66
Pain Relevance 0.40

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (CD83) plasma membrane (CD83)
Anatomy Link Frequency
CD86 4
CD83 (Homo sapiens)
Pain Link Frequency Relevance Heat
Multiple sclerosis 65 100.00 Very High Very High Very High
cINOD 11 76.56 Quite High
cytokine 12 67.52 Quite High
imagery 45 67.48 Quite High
Inflammation 46 65.68 Quite High
Potency 2 47.32 Quite Low
Chronic pancreatitis 10 6.08 Low Low
chemokine 16 5.00 Very Low Very Low Very Low
positron emission tomography 12 5.00 Very Low Very Low Very Low
Central nervous system 6 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Multiple Sclerosis 69 100.00 Very High Very High Very High
Cancer 184 99.60 Very High Very High Very High
Disease 18 96.20 Very High Very High Very High
Carcinoma 2 95.52 Very High Very High Very High
Adenocarcinoma 90 93.68 High High
Glioblastoma 36 85.48 High High
INFLAMMATION 57 76.36 Quite High
Photosensitivity Disorders 27 72.60 Quite High
Necrosis 6 71.08 Quite High
Glioma 56 70.12 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Minor or irrelevant modifications in CD83 expression were observed (CPZ treated, irradiated cells versus irradiated control, Fig. 3A) and only a slight increase in HLA-DR expression was induced by CPZ under irradiation (Fig. 3B).
Regulation (modifications) of Gene_expression (expression) of CD83
1) Confidence 0.55 Published 2010 Journal PLoS ONE Section Body Doc Link PMC3009729 Disease Relevance 0.14 Pain Relevance 0.08
The impact of irradiation on the chosen biomarkers (CD86, CD83 and HLA-DR) expression was examined.
Spec (examined) Regulation (impact) of Gene_expression (expression) of CD83 in CD86
2) Confidence 0.40 Published 2010 Journal PLoS ONE Section Body Doc Link PMC3009729 Disease Relevance 0.13 Pain Relevance 0
While CD80 expression was consistent in each culture condition, CD83 expression was much more sensitive to the differing conditions.
Regulation (sensitive) of Gene_expression (expression) of CD83
3) Confidence 0.29 Published 2008 Journal Biologics : Targets & Therapy Section Body Doc Link PMC2727883 Disease Relevance 0.50 Pain Relevance 0
The removal of the tumor had no or very low effect on CD83 levels when measured ?
Neg (no) Regulation (effect) of Gene_expression (levels) of CD83 associated with cancer
4) Confidence 0.26 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2955544 Disease Relevance 0.88 Pain Relevance 0.03
From concentration-dependent changes in CD83 expression, we found an apparent ID50 >>1.5 micromol/L sulfasalazine.
Regulation (changes) of Gene_expression (expression) of CD83
5) Confidence 0.25 Published 2001 Journal Croat. Med. J. Section Body Doc Link 11471196 Disease Relevance 0 Pain Relevance 0
On the other hand, the expression of the maturation marker CD83 was not affected under these irradiation conditions (Fig. 1B).
Neg (not) Regulation (affected) of Gene_expression (expression) of CD83
6) Confidence 0.24 Published 2010 Journal PLoS ONE Section Body Doc Link PMC3009729 Disease Relevance 0.12 Pain Relevance 0
At day 5, U-251 tumor cell lysate was added to the generated immature DCs and by day 6, cell started exhibiting morphological changes that were accompanied with the further changes in the expression of DCs' phenotypical markers such as CD83, CD86, HLA-DR (Figure 1, Supplemental material, Table S1).
Regulation (changes) of Gene_expression (expression) of CD83 in CD86 associated with cancer
7) Confidence 0.11 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2829084 Disease Relevance 0.50 Pain Relevance 0.10
When analyzed in this way, CD83 expression in the MS samples was down regulated by 0.58-fold, SERPINB9 expression was up regulated by 2.47-fold, and CD9 expression was up regulated 3.5-fold relative to the Control samples (Table 6) and these results are in concordance with array data for these genes.
Regulation (regulated) of Gene_expression (expression) of CD83 associated with multiple sclerosis
8) Confidence 0.10 Published 2008 Journal BMC Med Genomics Section Body Doc Link PMC2227948 Disease Relevance 0.39 Pain Relevance 0.19

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