INT97142

Context Info Confidence 0.73 First Reported 2001 Last Reported 2010 Negated 0 Speculated 0 Reported most in Body Documents 5 Total Number 5 Disease Relevance 1.73 Pain Relevance 1.46

extracellular space (IL12B) extracellular region (IL12B) cytoplasm (IL12B)

Anatomy Link Frequency monocytes 1 dendritic cell 1 IL12B (Homo sapiens)

Pain Link Frequency Relevance Heat Inflammation 120 99.70 dexamethasone 86 99.42 cytokine 80 95.68 Inflammatory response 5 84.84 agonist 16 55.24 chemokine 11 5.00 Potency 6 5.00 cINOD 3 5.00 Pain 2 5.00 Inflammatory marker 2 5.00

Disease Link Frequency Relevance Heat INFLAMMATION 132 99.70 Infection 60 93.32 Sprains And Strains 54 90.28 Amebiasis 22 85.36 American Trypanosomiasis 3 75.00 Parasitemia 13 49.28 Necrosis 3 40.12 Cancer 3 39.76 Shock 3 29.36 Malaria 1 19.44

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

Also, a stronger inflammatory TH1 response, represented by IL-12p40, IFN?

Localization (represented) of IL-12p40 associated with inflammation

1) Confidence 0.73 Published 2010 Journal Journal of Biomedicine and Biotechnology Section Abstract Doc Link PMC2852613 Disease Relevance 0.92 Pain Relevance 0.05

The interaction of LPPG with TLR2 and TLR4 resulted in activation of NF-kappaB and release of IL-8, IL-10, IL-12p40, and TNF-alpha from human monocytes [85, 96].

Localization (release) of IL-12p40 in monocytes

2) Confidence 0.68 Published 2010 Journal Journal of Biomedicine and Biotechnology Section Body Doc Link PMC2817369 Disease Relevance 0.38 Pain Relevance 0.08

We quantified the effect of drugs on the dendritic cell characteristics, such as stimulation of autologous and allogeneic pan-T cell proliferation, surface marker phenotype, IL-12 p40 subunit secretion, and activation of nuclear transcription factor (NF)-kappa B.

Localization (secretion) of IL-12 p40 subunit in dendritic cell

3) Confidence 0.24 Published 2001 Journal Croat. Med. J. Section Body Doc Link 11471196 Disease Relevance 0 Pain Relevance 0

Both BOL-303242-X and DEX inhibited LPS-induced IL-6, IL-12p40, and MCP-1 release in a dose-dependent manner, and a statistically significant inhibitory effect on IL-6, IL-12p40, and MCP-1 release was observed at 1 nM (Figure 5).

Localization (release) of IL-12p40 associated with dexamethasone

4) Confidence 0.03 Published 2009 Journal Molecular Vision Section Body Doc Link PMC2790480 Disease Relevance 0.22 Pain Relevance 0.64

Both BOL-303242-X and DEX inhibited LPS-induced IL-6, IL-12p40, and MCP-1 release in a dose-dependent manner, and a statistically significant inhibitory effect on IL-6, IL-12p40, and MCP-1 release was observed at 1 nM (Figure 5).

Localization (release) of IL-12p40 associated with dexamethasone

5) Confidence 0.01 Published 2009 Journal Molecular Vision Section Body Doc Link PMC2790480 Disease Relevance 0.21 Pain Relevance 0.69

General Comments

This test has worked.