INT97142

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Context Info
Confidence 0.73
First Reported 2001
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 5
Total Number 5
Disease Relevance 1.73
Pain Relevance 1.46

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (IL12B) extracellular region (IL12B) cytoplasm (IL12B)
Anatomy Link Frequency
monocytes 1
dendritic cell 1
IL12B (Homo sapiens)
Pain Link Frequency Relevance Heat
Inflammation 120 99.70 Very High Very High Very High
dexamethasone 86 99.42 Very High Very High Very High
cytokine 80 95.68 Very High Very High Very High
Inflammatory response 5 84.84 Quite High
agonist 16 55.24 Quite High
chemokine 11 5.00 Very Low Very Low Very Low
Potency 6 5.00 Very Low Very Low Very Low
cINOD 3 5.00 Very Low Very Low Very Low
Pain 2 5.00 Very Low Very Low Very Low
Inflammatory marker 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
INFLAMMATION 132 99.70 Very High Very High Very High
Infection 60 93.32 High High
Sprains And Strains 54 90.28 High High
Amebiasis 22 85.36 High High
American Trypanosomiasis 3 75.00 Quite High
Parasitemia 13 49.28 Quite Low
Necrosis 3 40.12 Quite Low
Cancer 3 39.76 Quite Low
Shock 3 29.36 Quite Low
Malaria 1 19.44 Low Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Also, a stronger inflammatory TH1 response, represented by IL-12p40, IFN?
Localization (represented) of IL-12p40 associated with inflammation
1) Confidence 0.73 Published 2010 Journal Journal of Biomedicine and Biotechnology Section Abstract Doc Link PMC2852613 Disease Relevance 0.92 Pain Relevance 0.05
The interaction of LPPG with TLR2 and TLR4 resulted in activation of NF-kappaB and release of IL-8, IL-10, IL-12p40, and TNF-alpha from human monocytes [85, 96].
Localization (release) of IL-12p40 in monocytes
2) Confidence 0.68 Published 2010 Journal Journal of Biomedicine and Biotechnology Section Body Doc Link PMC2817369 Disease Relevance 0.38 Pain Relevance 0.08
We quantified the effect of drugs on the dendritic cell characteristics, such as stimulation of autologous and allogeneic pan-T cell proliferation, surface marker phenotype, IL-12 p40 subunit secretion, and activation of nuclear transcription factor (NF)-kappa B.
Localization (secretion) of IL-12 p40 subunit in dendritic cell
3) Confidence 0.24 Published 2001 Journal Croat. Med. J. Section Body Doc Link 11471196 Disease Relevance 0 Pain Relevance 0
Both BOL-303242-X and DEX inhibited LPS-induced IL-6, IL-12p40, and MCP-1 release in a dose-dependent manner, and a statistically significant inhibitory effect on IL-6, IL-12p40, and MCP-1 release was observed at 1 nM (Figure 5).
Localization (release) of IL-12p40 associated with dexamethasone
4) Confidence 0.03 Published 2009 Journal Molecular Vision Section Body Doc Link PMC2790480 Disease Relevance 0.22 Pain Relevance 0.64
Both BOL-303242-X and DEX inhibited LPS-induced IL-6, IL-12p40, and MCP-1 release in a dose-dependent manner, and a statistically significant inhibitory effect on IL-6, IL-12p40, and MCP-1 release was observed at 1 nM (Figure 5).
Localization (release) of IL-12p40 associated with dexamethasone
5) Confidence 0.01 Published 2009 Journal Molecular Vision Section Body Doc Link PMC2790480 Disease Relevance 0.21 Pain Relevance 0.69

General Comments

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