INT97144

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.39
First Reported 2001
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 5
Total Number 5
Disease Relevance 2.28
Pain Relevance 0.54

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (CD83) plasma membrane (CD83)
Anatomy Link Frequency
CD86 2
PDL-1 1
dendritic cells 1
CD83 (Homo sapiens)
Pain Link Frequency Relevance Heat
Multiple sclerosis 68 99.84 Very High Very High Very High
Inflammation 49 95.32 Very High Very High Very High
Central nervous system 4 78.48 Quite High
chemokine 16 76.96 Quite High
psoriasis 68 76.32 Quite High
cytokine 31 62.80 Quite High
rheumatoid arthritis 6 54.48 Quite High
Infliximab 15 5.00 Very Low Very Low Very Low
Etanercept 13 5.00 Very Low Very Low Very Low
Chronic pancreatitis 10 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Multiple Sclerosis 69 99.84 Very High Very High Very High
Adhesions 8 99.20 Very High Very High Very High
Apoptosis 11 97.72 Very High Very High Very High
INFLAMMATION 53 95.32 Very High Very High Very High
Photosensitivity Disorders 9 85.56 High High
Phototoxic Dermatitis 12 85.12 High High
Adenocarcinoma 90 84.12 Quite High
Disease 30 79.88 Quite High
Dermatitis 2 78.96 Quite High
Death 2 76.68 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In distinction to drug-free maturing dendritic cells, 2.5 micromol/L sulfasalazine upregulated the levels of CD14 and CD68 and downregulated the levels of CD40, CD80, and CD83 (for all CD markers, p<0.03 for difference between measurements in the absence and the presence of sulfasalazine).
Negative_regulation (downregulated) of CD83 in dendritic cells
1) Confidence 0.39 Published 2001 Journal Croat. Med. J. Section Body Doc Link 11471196 Disease Relevance 0 Pain Relevance 0
Following a 48 h incubation, the expression of the cell surface molecules CD86, HLA-DR and CD83 was measured by flow cytometry.
Negative_regulation (measured) of CD83 in CD86
2) Confidence 0.38 Published 2010 Journal PLoS ONE Section Abstract Doc Link PMC3009729 Disease Relevance 0.39 Pain Relevance 0
In addition, the LC also acquires a number of cell surface receptor markers such as CD80, CD86, CD40, CD83, and intercellular adhesion molecule (ICAM) 1.
Negative_regulation (number) of CD83 in CD86 associated with adhesions
3) Confidence 0.18 Published 2008 Journal Indian Journal of Pharmacology Section Body Doc Link PMC2792605 Disease Relevance 0.43 Pain Relevance 0.15
The gene for CD83 was downregulated in MS siblings.
Negative_regulation (downregulated) of CD83 associated with multiple sclerosis
4) Confidence 0.16 Published 2008 Journal BMC Med Genomics Section Body Doc Link PMC2227948 Disease Relevance 1.15 Pain Relevance 0.36
The TLR3 ligation induced a MDC maturation profile with upregulation of the markers; CD40, CD83, CD86, CCR7, PDL-1, and downregulation of ICOSL, B7H3, and CCR5 (Figure 9).
Negative_regulation (downregulation) of CD83 in PDL-1
5) Confidence 0.11 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2955544 Disease Relevance 0.30 Pain Relevance 0.03

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox