INT97145

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.12
First Reported 2001
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 14
Total Number 21
Disease Relevance 15.32
Pain Relevance 5.43

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (TBK1) plasma membrane (TBK1) cytoplasm (TBK1)
Anatomy Link Frequency
cartilage 1
dendritic cells 1
nucleus 1
eosinophils 1
leukocyte 1
TBK1 (Homo sapiens)
Pain Link Frequency Relevance Heat
Inflammation 1091 99.28 Very High Very High Very High
Inflammatory response 186 99.24 Very High Very High Very High
COX-2 inhibitor 23 99.04 Very High Very High Very High
dexamethasone 114 98.20 Very High Very High Very High
cINOD 289 98.16 Very High Very High Very High
ischemia 5 97.08 Very High Very High Very High
Inflammatory stimuli 77 96.64 Very High Very High Very High
cytokine 191 96.60 Very High Very High Very High
aspirin 82 94.80 High High
Inflammatory mediators 24 92.96 High High
Disease Link Frequency Relevance Heat
Adhesions 47 99.52 Very High Very High Very High
Cancer 307 99.42 Very High Very High Very High
INFLAMMATION 1332 99.28 Very High Very High Very High
Apoptosis 69 99.22 Very High Very High Very High
Stress 30 98.88 Very High Very High Very High
Reperfusion Injury 2 97.84 Very High Very High Very High
Cv Unclassified Under Development 6 97.08 Very High Very High Very High
Multiple Myeloma 93 95.08 Very High Very High Very High
Pressure And Volume Under Development 41 93.84 High High
Death 23 93.28 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Qualitatively, the dynamic IKK activity corresponds to its intracellular concentration and it serves as the “input signal” for the subsequent activation of NF-kB signaling module, Eq. (2).(2)
Positive_regulation (activation) of NF-kB
1) Confidence 0.12 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2651450 Disease Relevance 0.33 Pain Relevance 0.16
Interestingly, in [32] Klinke et al. aim at exploring experimentally the possibility of modulating the temporal control of NF-kB activation.
Positive_regulation (activation) of NF-kB
2) Confidence 0.12 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2651450 Disease Relevance 0.63 Pain Relevance 0.40
At 1.25 micromol/L, sulfasalazine largely inhibited NF-kB activation in dendritic cells.
Positive_regulation (activation) of NF-kB in dendritic cells
3) Confidence 0.09 Published 2001 Journal Croat. Med. J. Section Body Doc Link 11471196 Disease Relevance 0 Pain Relevance 0
is a potent inducer of NF-kB in eosinophils [10] we can hypothesize that dexamethasone inhibits GM-CSF and IL-8 release in TNF-?
Positive_regulation (inducer) of NF-kB in eosinophils associated with dexamethasone
4) Confidence 0.08 Published 2005 Journal Clin Mol Allergy Section Body Doc Link PMC1131914 Disease Relevance 0.46 Pain Relevance 0.43
Epigallocatechin-3 galate inhibits IL-1–induced proteoglycan release and type 2 collagen degradation in cartilage explants.[44] In human in vitro models, it also suppresses IL-1b and attenuates activation of the transcription factor NF-kB.
Positive_regulation (activation) of NF-kB in cartilage
5) Confidence 0.07 Published 2010 Journal Surgical Neurology International Section Body Doc Link PMC3011108 Disease Relevance 0.67 Pain Relevance 0.14
This herb has been shown to prevent the activation of the transcriptional factor NF-kB and it directly inhibits TNF-?
Positive_regulation (activation) of NF-kB
6) Confidence 0.07 Published 2010 Journal Surgical Neurology International Section Body Doc Link PMC3011108 Disease Relevance 0.74 Pain Relevance 0.11
Immunosuppressant drugs also reduce nuclear expression of NF-kB.[397075] Research now indicates that blocking the activation of NF-kB along with other inflammation mediators [Table 2] is the major mechanism for reducing inflammation by natural compounds.


Positive_regulation (activation) of NF-kB associated with inflammation
7) Confidence 0.07 Published 2010 Journal Surgical Neurology International Section Body Doc Link PMC3011108 Disease Relevance 0.76 Pain Relevance 0.59
These agents inhibit the NF-kB pathway in endothelial cells and block NF-kB activation to inhibit leukocyte recruitment.[114115116] NSAIDs have also been found to inhibit both the COX system and the NF-kB pathway.
Positive_regulation (activation) of NF-kB in leukocyte associated with cinod
8) Confidence 0.07 Published 2010 Journal Surgical Neurology International Section Body Doc Link PMC3011108 Disease Relevance 0.90 Pain Relevance 0.69
It ultimately inhibits the activation of the transcription factor NF-kB by protecting its inhibitor (IkB) from degradation by the proteasome complex (Fig. 2).
Positive_regulation (activation) of NF-kB
9) Confidence 0.07 Published 2007 Journal Clin Exp Med Section Body Doc Link PMC2779346 Disease Relevance 0.42 Pain Relevance 0.03
In vitro inhibition of COX-2 with targeted molecules is thought to promote apoptosis of cancer cells through inhibition of NF-kB activation [20].
Positive_regulation (activation) of NF-kB associated with cancer and apoptosis
10) Confidence 0.06 Published 2007 Journal BMC Cancer Section Body Doc Link PMC2234426 Disease Relevance 1.20 Pain Relevance 0.38
The other important receptors in the immune system, TLR family members (TLR2 and TLR4), which recognize pathogens by means of conserved structural features of the microbes such as LPS for Gram-negative bacteria, would involve in activating the MyD88/IRAK signaling cascade, which bifurcates and leads to NF-kB and c-Jun/ATF2/TCF activation [17].
Positive_regulation (activation) of NF-kB in immune system
11) Confidence 0.06 Published 2008 Journal BMC Med Genomics Section Body Doc Link PMC2567339 Disease Relevance 0.21 Pain Relevance 0.13
- and IL-1b-induced NF-kB activation.
Positive_regulation (induced) of NF-kB
12) Confidence 0.05 Published 2010 Journal Surgical Neurology International Section Body Doc Link PMC3011108 Disease Relevance 0.85 Pain Relevance 0.35
Degradation of IkB by proteasome activates NF-kB, which moves to the nucleus and up-regulates transcription of proteins that promote cell survival and growth, reduce susceptibility to apoptosis, influence the expression of adhesion molecules and induce drug resistance in myeloma cells.
Positive_regulation (activates) of NF-kB in nucleus associated with apoptosis and adhesions
13) Confidence 0.05 Published 2007 Journal Clin Exp Med Section Body Doc Link PMC2779346 Disease Relevance 0.54 Pain Relevance 0
These receptors induce transmembrane signals that activate NF-kB and mitogen dependent protein kinase pathways [4].
Positive_regulation (activate) of NF-kB
14) Confidence 0.05 Published 2005 Journal Immun Ageing Section Body Doc Link PMC1166571 Disease Relevance 0.63 Pain Relevance 0.20
–induced NF-kB activation as well as adhesion molecule expression in the endothelium.
Positive_regulation (activation) of NF-kB in endothelium associated with adhesions
15) Confidence 0.05 Published 2010 Journal Surgical Neurology International Section Body Doc Link PMC3011108 Disease Relevance 0.85 Pain Relevance 0.22
Resveratrol shows the anti-inflammatory properties as it suppresses COX-2 by blocking NF-kB activation.
Positive_regulation (activation) of NF-kB associated with inflammation
16) Confidence 0.05 Published 2010 Journal Surgical Neurology International Section Body Doc Link PMC3011108 Disease Relevance 0.82 Pain Relevance 0.33
Grimm et al, recently reported that oral intake of pycnogenol inhibited NF-kB activation in lipopolysaccharide-stimulated monocytes as well, thus decreasing the inflammatory response.
Positive_regulation (activation) of NF-kB in monocytes associated with inflammatory response
17) Confidence 0.05 Published 2010 Journal Surgical Neurology International Section Body Doc Link PMC3011108 Disease Relevance 0.86 Pain Relevance 0.21
Simultaneously with a marked increase in NF-kB activity, there is over-expression of the pro-apoptotic protein Bax, and down-regulation of the anti-apoptotic protein Bcl-2.
Positive_regulation (increase) of NF-kB associated with apoptosis
18) Confidence 0.05 Published 2008 Journal Mol Cancer Section Body Doc Link PMC2615789 Disease Relevance 1.44 Pain Relevance 0
of IkB, induction of TSC22, NF-kB, GADD153, PTEN, etc.) may depend on the
Positive_regulation (induction) of NF-kB
19) Confidence 0.04 Published 2008 Journal PPAR Research Section Body Doc Link PMC2464819 Disease Relevance 0.79 Pain Relevance 0
For example, TNFAIP3 displays potent anti-inflammatory properties in a number of different cell types, through the inhibition of NF-kB activation and prevention of TLR-mediated responses [43]–[48].
Positive_regulation (activation) of NF-kB associated with inflammation
20) Confidence 0.03 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2654409 Disease Relevance 1.02 Pain Relevance 0.47

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox