INT97152

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Context Info
Confidence 0.74
First Reported 2001
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 11
Total Number 11
Disease Relevance 8.03
Pain Relevance 2.30

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (COL1A1) extracellular region (COL1A1) cytoplasm (COL1A1)
Anatomy Link Frequency
cartilage 2
monocytes 1
brain 1
TMJ 1
lacuna 1
COL1A1 (Homo sapiens)
Pain Link Frequency Relevance Heat
Osteoarthritis 48 100.00 Very High Very High Very High
Snapping jaw 6 100.00 Very High Very High Very High
metalloproteinase 7 93.84 High High
imagery 10 93.36 High High
Central nervous system 32 92.24 High High
Chronic pancreatitis 33 92.04 High High
Arthritis 41 89.76 High High
Pain 9 89.12 High High
cytokine 34 84.52 Quite High
Inflammation 60 75.00 Quite High
Disease Link Frequency Relevance Heat
Choroideremia 166 100.00 Very High Very High Very High
Osteoarthritis 47 100.00 Very High Very High Very High
Temporomandibular Joint Syndrome 6 100.00 Very High Very High Very High
Alpha-1-antitrypsin Deficiency 5 100.00 Very High Very High Very High
Viral Meningitis 84 99.64 Very High Very High Very High
Hypercalcemia 32 99.18 Very High Very High Very High
Obesity 25 98.70 Very High Very High Very High
Primary Sclerosing Cholangitis 77 97.72 Very High Very High Very High
Injury 6 96.20 Very High Very High Very High
Pulmonary Hypertension 1 95.90 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In addition, collagen I is the major supporting protein of the TMJ disc and will degrade as osteoarthritis progresses.
Protein_catabolism (degrade) of collagen I in TMJ associated with snapping jaw and osteoarthritis
1) Confidence 0.74 Published 2009 Journal J. Oral Maxillofac. Surg. Section Abstract Doc Link 19070755 Disease Relevance 0.82 Pain Relevance 0.58
As shown in Tables 6 and 7, the 17-peptide biomarkers were found to be degradation products of eight different proteins: alpha1 antitrypsin (A1AT, two peptides having overlapping sequences), collagen type I alpha 1 (COL1A1; five peptides and three of them having overlapping sequences), collagen type I alpha 2 (COL1A2; one peptide), collagen type III alpha 1 (COL3A1; one peptide), collagen type IX alpha 2 (COL9A2; one peptide), fibrinogen alpha (FGA; two peptides having overlapping sequences), fibrinogen beta (FGB; two peptides having overlapping sequences), and uromodulin (UMOD; three peptides having overlapping sequences).
Protein_catabolism (degradation) of collagen type I alpha 1 associated with alpha-1-antitrypsin deficiency
2) Confidence 0.64 Published 2010 Journal Clin Proteomics Section Body Doc Link PMC2970804 Disease Relevance 0.78 Pain Relevance 0.12
HRT caused a pronounced decrease in the collagen type I degradation marker, CTX-I, both when the HRT and control groups were compared (P < 0.001) and within the HRT group (P < 0.001) (Fig. 1a).
Protein_catabolism (degradation) of collagen type I
3) Confidence 0.16 Published 2004 Journal Arthritis Res Ther Section Body Doc Link PMC546286 Disease Relevance 0 Pain Relevance 0.03
Recently, Brain Natriuretic Peptide (BNP) has been proposed as a good biomarker for assessing prognosis and follow-up in pulmonary arterial hypertension.[23] Another example of development of new biomarker under the aegis of CPI is that of protein degradation fragments called neoepitopes which have proven useful for research on bone and cartilage and are collagen type I and collagen type II degradation products, respectively.
Protein_catabolism (degradation) of collagen type I in cartilage associated with natriuresis and pulmonary hypertension
4) Confidence 0.10 Published 2010 Journal Journal of Pharmacy and Bioallied Sciences Section Body Doc Link PMC2996064 Disease Relevance 0.27 Pain Relevance 0
Correlations between gender, KL score, or BMI and the bone resorption marker, serum C-terminal telopeptide of collagen type I (CTX-I), or the cartilage degradation marker, urine C-terminal telopeptide of collagen type II (CTX-II) were investigated.


Protein_catabolism (degradation) of collagen type I in cartilage associated with obesity and hypercalcemia
5) Confidence 0.06 Published 2010 Journal BMC Musculoskelet Disord Section Abstract Doc Link PMC2902412 Disease Relevance 1.16 Pain Relevance 0.32
LPS and TNFalpha induced collagen1 and fibronectin levels as well as the matrix degradation enzyme MMP-1.
Protein_catabolism (degradation) of collagen1
6) Confidence 0.05 Published 2007 Journal J Transl Med Section Abstract Doc Link PMC2234395 Disease Relevance 1.65 Pain Relevance 0.89
Deoxypyridinium (DPD) cross-links are a specific parameter for collagen type I degradation.
Protein_catabolism (degradation) of collagen type I
7) Confidence 0.05 Published 2001 Journal Int. J. Biol. Markers Section Abstract Doc Link 11471897 Disease Relevance 0.61 Pain Relevance 0.16
It is secreted in the resorption lacuna [48,49] where it degrades collagen I at acidic pH.
Protein_catabolism (degrades) of collagen I in lacuna
8) Confidence 0.02 Published 2009 Journal Orphanet J Rare Dis Section Body Doc Link PMC2654865 Disease Relevance 0.66 Pain Relevance 0.05
Here we showed that both the serine and metalloproteases of the AGE isolate exhibits collagen I and collagen III degradation suggesting that these proteases may facilitate amoebic migration into deeper tissues by degrading the ECM.
Protein_catabolism (degradation) of collagen I associated with viral meningitis
9) Confidence 0.02 Published 2006 Journal BMC Microbiol Section Body Doc Link PMC1464133 Disease Relevance 0.50 Pain Relevance 0.08
These proteases degrade extracellular matrix (ECM), which provide structural and functional support to the brain tissue, as shown by the degradation of collagen I and III (major components of collagenous ECM), elastin (elastic fibrils of ECM), plasminogen (involved in proteolytic degradation of ECM), as well as casein and haemoglobin.
Protein_catabolism (degradation) of collagen I in brain
10) Confidence 0.02 Published 2006 Journal BMC Microbiol Section Abstract Doc Link PMC1464133 Disease Relevance 0.59 Pain Relevance 0.04
With the use of pHrodo™ BioParticles® conjugated with E. coli, collagen I coated FluoSpheres beads and fluorescent DQ™ ovalbumin with BODYPY FL dye, we demonstrated for the first time that lysosomal pH was increased in monocytes of CHM patients and, as a consequence, the rates of proteolytic degradation were slowed.
Protein_catabolism (degradation) of collagen I in monocytes associated with choroideremia
11) Confidence 0.02 Published 2009 Journal PLoS ONE Section Abstract Doc Link PMC2793004 Disease Relevance 1.00 Pain Relevance 0.04

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