INT97179

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Context Info
Confidence 0.67
First Reported 2001
Last Reported 2009
Negated 0
Speculated 4
Reported most in Abstract
Documents 17
Total Number 21
Disease Relevance 4.54
Pain Relevance 0.30

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Pgr) nucleolus (Pgr) nucleus (Pgr)
enzyme binding (Pgr) cytoplasm (Pgr)
Anatomy Link Frequency
hypothalamus 4
reproductive organ 2
brain 2
pituitary 2
uterine 2
Pgr (Rattus norvegicus)
Pain Link Frequency Relevance Heat
agonist 66 99.40 Very High Very High Very High
Bile 1 71.64 Quite High
cytokine 22 65.92 Quite High
Dismenorea 24 50.00 Quite Low
Acupuncture 8 50.00 Quite Low
Inflammation 9 49.52 Quite Low
Enkephalin 14 25.00 Low Low
anesthesia 14 5.00 Very Low Very Low Very Low
imagery 9 5.00 Very Low Very Low Very Low
Potency 6 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Breast Cancer 18 99.90 Very High Very High Very High
Urological Neuroanatomy 20 98.98 Very High Very High Very High
Cancer 22 96.56 Very High Very High Very High
Targeted Disruption 48 94.88 High High
Anxiety Disorder 6 93.88 High High
Necrosis 2 91.12 High High
Metastasis 23 90.08 High High
Apoptosis 1 89.04 High High
Endometriosis 1 88.12 High High
Advanced Or Metastatic Breast Cancer 5 85.12 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The serum levels of follicle stimulating hormone (FSH), luteinizing hormone (LH), estradiol (E2), and progesterone (P) were detected by radioimmunoassay, and the expression of gonadotropin-releasing hormone (GnRH) mRNA in hypothalamus and ovary, GnRH receptor (GnRH-R) mRNA in pituitary, estrodiol receptor (ER) mRNA and progesterone receptor (PR) mRNA in uterus were determined using RT-PCR.
Spec (determined) Transcription (expression) of PR in ovary
1) Confidence 0.67 Published 2009 Journal Zhen Ci Yan Jiu Section Body Doc Link 19526799 Disease Relevance 0.13 Pain Relevance 0
We investigated effects of pre- and postnatal exposure to 4-MBC in the same rat offspring at brain and reproductive organ levels. 4-MBC (7, 24, 47 mg/kg/day) was administered in chow to the parent generation before mating, during gestation and lactation, and to the offspring until adulthood. mRNA of estrogen target genes involved in control of sexual behavior and gonadal functions was measured by real-time RT-PCR in ventromedial hypothalamic nucleus (VMH) and medial preoptic area (MPO) of adult offspring. 4-MBC exposure affected mRNA levels of ER alpha, progesterone receptor (PR), preproenkephalin (PPE) and insulin-like growth factor-I (IGF-I) in a sex- and region-specific manner.
Transcription (levels) of progesterone receptor in reproductive organ associated with urological neuroanatomy
2) Confidence 0.61 Published 2007 Journal Toxicol. Appl. Pharmacol. Section Abstract Doc Link 17188730 Disease Relevance 0.44 Pain Relevance 0
We investigated effects of pre- and postnatal exposure to 4-MBC in the same rat offspring at brain and reproductive organ levels. 4-MBC (7, 24, 47 mg/kg/day) was administered in chow to the parent generation before mating, during gestation and lactation, and to the offspring until adulthood. mRNA of estrogen target genes involved in control of sexual behavior and gonadal functions was measured by real-time RT-PCR in ventromedial hypothalamic nucleus (VMH) and medial preoptic area (MPO) of adult offspring. 4-MBC exposure affected mRNA levels of ER alpha, progesterone receptor (PR), preproenkephalin (PPE) and insulin-like growth factor-I (IGF-I) in a sex- and region-specific manner.
Transcription (levels) of PR in reproductive organ associated with urological neuroanatomy
3) Confidence 0.59 Published 2007 Journal Toxicol. Appl. Pharmacol. Section Abstract Doc Link 17188730 Disease Relevance 0.45 Pain Relevance 0
Since little is known about their action on gene expression in the adult hypothalamus, we examined the effects of these chemicals on the expression of estrogen-regulated mRNAs, i.e., progesterone receptor (PR) mRNA, preproenkephalin (PPE) mRNA and neurotensin (NT) mRNA, in the hypothalamus and pituitary of adult female rats.
Transcription (expression) of progesterone receptor in pituitary
4) Confidence 0.44 Published 2001 Journal Neuroendocrinology Section Abstract Doc Link 11474214 Disease Relevance 0 Pain Relevance 0
Since little is known about their action on gene expression in the adult hypothalamus, we examined the effects of these chemicals on the expression of estrogen-regulated mRNAs, i.e., progesterone receptor (PR) mRNA, preproenkephalin (PPE) mRNA and neurotensin (NT) mRNA, in the hypothalamus and pituitary of adult female rats.
Transcription (expression) of PR in pituitary
5) Confidence 0.44 Published 2001 Journal Neuroendocrinology Section Abstract Doc Link 11474214 Disease Relevance 0 Pain Relevance 0
DPN decreased the uterine PR mRNA level as compared to controls [31], which is in agreement with our present finding in this short time study.
Transcription (level) of PR in uterine
6) Confidence 0.39 Published 2006 Journal Reprod Biol Endocrinol Section Body Doc Link PMC1586009 Disease Relevance 0.09 Pain Relevance 0
The PR mRNA levels do not vary in the rat uterus during the estrous cycle, suggesting that the expression of PR is primarily regulated post-translationally and/or translationally [30].
Transcription (levels) of PR in uterus
7) Confidence 0.39 Published 2006 Journal Reprod Biol Endocrinol Section Body Doc Link PMC1586009 Disease Relevance 0.06 Pain Relevance 0
The present study demonstrates that the two endocrine disrupters BPA and BBP can increase the expression of PR mRNA in the POA of adult ovariectomized rats.
Transcription (expression) of PR in POA
8) Confidence 0.32 Published 2001 Journal Neuroendocrinology Section Abstract Doc Link 11474214 Disease Relevance 0 Pain Relevance 0
PR mRNA expression in (experiment 3)
Transcription (expression) of PR
9) Confidence 0.30 Published 2006 Journal Reprod Biol Endocrinol Section Body Doc Link PMC1586009 Disease Relevance 0.13 Pain Relevance 0
We did not find any effect of the other treatments on PR mRNA expression in this short time study (Fig 8).


Transcription (expression) of PR
10) Confidence 0.30 Published 2006 Journal Reprod Biol Endocrinol Section Body Doc Link PMC1586009 Disease Relevance 0.24 Pain Relevance 0
The ERbeta agonist DPN caused a decrease of the PR mRNA levels, which was also found for PRAB and PRB immunostaining in the GE.


Transcription (levels) of PR associated with agonist
11) Confidence 0.30 Published 2006 Journal Reprod Biol Endocrinol Section Abstract Doc Link PMC1586009 Disease Relevance 0 Pain Relevance 0.23
mediated effects on PR mRNA levels could be obscured due to the mixture of cell types in the uterine homogenate used for PCR.
Transcription (levels) of PR in uterine
12) Confidence 0.30 Published 2006 Journal Reprod Biol Endocrinol Section Body Doc Link PMC1586009 Disease Relevance 0.18 Pain Relevance 0
The serum levels of follicle stimulating hormone (FSH), luteinizing hormone (LH), estradiol (E2), and progesterone (P) were detected by radioimmunoassay, and the expression of gonadotropin-releasing hormone (GnRH) mRNA in hypothalamus and ovary, GnRH receptor (GnRH-R) mRNA in pituitary, estrodiol receptor (ER) mRNA and progesterone receptor (PR) mRNA in uterus were determined using RT-PCR.
Spec (determined) Transcription (expression) of progesterone receptor in ovary
13) Confidence 0.24 Published 2009 Journal Zhen Ci Yan Jiu Section Body Doc Link 19526799 Disease Relevance 0.13 Pain Relevance 0
The serum levels of follicle stimulating hormone (FSH), luteinizing hormone (LH), estradiol (E2), and progesterone (P) were detected by radioimmunoassay, and the expression of gonadotropin-releasing hormone (GnRH) mRNA in hypothalamus and ovary, GnRH receptor (GnRH-R) mRNA in pituitary, estrodiol receptor (ER) mRNA and progesterone receptor (PR) mRNA in uterus were determined using RT-PCR.
Spec (determined) Transcription (expression) of PR in hypothalamus
14) Confidence 0.23 Published 2009 Journal Zhen Ci Yan Jiu Section Body Doc Link 19526799 Disease Relevance 0.13 Pain Relevance 0
B binding to DNA by PR which did not depend upon the presence of ligand and, presumably, was not related to the transcriptional activity of PR.
Transcription (activity) of PR
15) Confidence 0.21 Published 2007 Journal Mediators of Inflammation Section Body Doc Link PMC2222592 Disease Relevance 0.50 Pain Relevance 0.03
We investigated effects of pre- and postnatal exposure to 4-MBC in the same rat offspring at brain and reproductive organ levels. 4-MBC (7, 24, 47 mg/kg/day) was administered in chow to the parent generation before mating, during gestation and lactation, and to the offspring until adulthood. mRNA of estrogen target genes involved in control of sexual behavior and gonadal functions was measured by real-time RT-PCR in ventromedial hypothalamic nucleus (VMH) and medial preoptic area (MPO) of adult offspring. 4-MBC exposure affected mRNA levels of ER alpha, progesterone receptor (PR), preproenkephalin (PPE) and insulin-like growth factor-I (IGF-I) in a sex- and region-specific manner.
Transcription (levels) of progesterone receptor in brain associated with urological neuroanatomy
16) Confidence 0.21 Published 2007 Journal Toxicol. Appl. Pharmacol. Section Abstract Doc Link 17188730 Disease Relevance 0.44 Pain Relevance 0
We investigated effects of pre- and postnatal exposure to 4-MBC in the same rat offspring at brain and reproductive organ levels. 4-MBC (7, 24, 47 mg/kg/day) was administered in chow to the parent generation before mating, during gestation and lactation, and to the offspring until adulthood. mRNA of estrogen target genes involved in control of sexual behavior and gonadal functions was measured by real-time RT-PCR in ventromedial hypothalamic nucleus (VMH) and medial preoptic area (MPO) of adult offspring. 4-MBC exposure affected mRNA levels of ER alpha, progesterone receptor (PR), preproenkephalin (PPE) and insulin-like growth factor-I (IGF-I) in a sex- and region-specific manner.
Transcription (levels) of PR in brain associated with urological neuroanatomy
17) Confidence 0.20 Published 2007 Journal Toxicol. Appl. Pharmacol. Section Abstract Doc Link 17188730 Disease Relevance 0.45 Pain Relevance 0
Since little is known about their action on gene expression in the adult hypothalamus, we examined the effects of these chemicals on the expression of estrogen-regulated mRNAs, i.e., progesterone receptor (PR) mRNA, preproenkephalin (PPE) mRNA and neurotensin (NT) mRNA, in the hypothalamus and pituitary of adult female rats.
Transcription (expression) of progesterone receptor in hypothalamus
18) Confidence 0.15 Published 2001 Journal Neuroendocrinology Section Abstract Doc Link 11474214 Disease Relevance 0 Pain Relevance 0
Since little is known about their action on gene expression in the adult hypothalamus, we examined the effects of these chemicals on the expression of estrogen-regulated mRNAs, i.e., progesterone receptor (PR) mRNA, preproenkephalin (PPE) mRNA and neurotensin (NT) mRNA, in the hypothalamus and pituitary of adult female rats.
Transcription (expression) of PR in hypothalamus
19) Confidence 0.15 Published 2001 Journal Neuroendocrinology Section Abstract Doc Link 11474214 Disease Relevance 0 Pain Relevance 0
The serum levels of follicle stimulating hormone (FSH), luteinizing hormone (LH), estradiol (E2), and progesterone (P) were detected by radioimmunoassay, and the expression of gonadotropin-releasing hormone (GnRH) mRNA in hypothalamus and ovary, GnRH receptor (GnRH-R) mRNA in pituitary, estrodiol receptor (ER) mRNA and progesterone receptor (PR) mRNA in uterus were determined using RT-PCR.
Spec (determined) Transcription (expression) of progesterone receptor in hypothalamus
20) Confidence 0.08 Published 2009 Journal Zhen Ci Yan Jiu Section Body Doc Link 19526799 Disease Relevance 0.13 Pain Relevance 0

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