INT97180

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Context Info
Confidence 0.38
First Reported 2001
Last Reported 2007
Negated 0
Speculated 2
Reported most in Abstract
Documents 5
Total Number 8
Disease Relevance 2.20
Pain Relevance 0

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Pgr) nucleolus (Pgr) nucleus (Pgr)
enzyme binding (Pgr) cytoplasm (Pgr)
Anatomy Link Frequency
reproductive organ 6
pituitary 3
brain 2
uterine 2
hypothalamus 1
Pgr (Rattus norvegicus)
Pain Link Frequency Relevance Heat
agonist 22 36.08 Quite Low
Enkephalin 8 25.00 Low Low
anesthesia 4 5.00 Very Low Very Low Very Low
imagery 2 5.00 Very Low Very Low Very Low
Potency 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Urological Neuroanatomy 20 99.26 Very High Very High Very High
Targeted Disruption 16 94.88 High High
Repression 4 70.80 Quite High
Anxiety Disorder 2 62.72 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
We investigated effects of pre- and postnatal exposure to 4-MBC in the same rat offspring at brain and reproductive organ levels. 4-MBC (7, 24, 47 mg/kg/day) was administered in chow to the parent generation before mating, during gestation and lactation, and to the offspring until adulthood. mRNA of estrogen target genes involved in control of sexual behavior and gonadal functions was measured by real-time RT-PCR in ventromedial hypothalamic nucleus (VMH) and medial preoptic area (MPO) of adult offspring. 4-MBC exposure affected mRNA levels of ER alpha, progesterone receptor (PR), preproenkephalin (PPE) and insulin-like growth factor-I (IGF-I) in a sex- and region-specific manner.
Regulation (affected) of Transcription (levels) of PR in reproductive organ associated with urological neuroanatomy
1) Confidence 0.38 Published 2007 Journal Toxicol. Appl. Pharmacol. Section Abstract Doc Link 17188730 Disease Relevance 0.45 Pain Relevance 0
We investigated effects of pre- and postnatal exposure to 4-MBC in the same rat offspring at brain and reproductive organ levels. 4-MBC (7, 24, 47 mg/kg/day) was administered in chow to the parent generation before mating, during gestation and lactation, and to the offspring until adulthood. mRNA of estrogen target genes involved in control of sexual behavior and gonadal functions was measured by real-time RT-PCR in ventromedial hypothalamic nucleus (VMH) and medial preoptic area (MPO) of adult offspring. 4-MBC exposure affected mRNA levels of ER alpha, progesterone receptor (PR), preproenkephalin (PPE) and insulin-like growth factor-I (IGF-I) in a sex- and region-specific manner.
Regulation (affected) of Transcription (levels) of progesterone receptor in reproductive organ associated with urological neuroanatomy
2) Confidence 0.38 Published 2007 Journal Toxicol. Appl. Pharmacol. Section Abstract Doc Link 17188730 Disease Relevance 0.44 Pain Relevance 0
Since little is known about their action on gene expression in the adult hypothalamus, we examined the effects of these chemicals on the expression of estrogen-regulated mRNAs, i.e., progesterone receptor (PR) mRNA, preproenkephalin (PPE) mRNA and neurotensin (NT) mRNA, in the hypothalamus and pituitary of adult female rats.
Spec (examined) Regulation (effects) of Transcription (expression) of progesterone receptor in pituitary
3) Confidence 0.17 Published 2001 Journal Neuroendocrinology Section Abstract Doc Link 11474214 Disease Relevance 0 Pain Relevance 0
mediated effects on PR mRNA levels could be obscured due to the mixture of cell types in the uterine homogenate used for PCR.
Regulation (effects) of Transcription (levels) of PR in uterine
4) Confidence 0.16 Published 2006 Journal Reprod Biol Endocrinol Section Body Doc Link PMC1586009 Disease Relevance 0.18 Pain Relevance 0
We did not find any effect of the other treatments on PR mRNA expression in this short time study (Fig 8).


Regulation (effect) of Transcription (expression) of PR
5) Confidence 0.16 Published 2006 Journal Reprod Biol Endocrinol Section Body Doc Link PMC1586009 Disease Relevance 0.24 Pain Relevance 0
We investigated effects of pre- and postnatal exposure to 4-MBC in the same rat offspring at brain and reproductive organ levels. 4-MBC (7, 24, 47 mg/kg/day) was administered in chow to the parent generation before mating, during gestation and lactation, and to the offspring until adulthood. mRNA of estrogen target genes involved in control of sexual behavior and gonadal functions was measured by real-time RT-PCR in ventromedial hypothalamic nucleus (VMH) and medial preoptic area (MPO) of adult offspring. 4-MBC exposure affected mRNA levels of ER alpha, progesterone receptor (PR), preproenkephalin (PPE) and insulin-like growth factor-I (IGF-I) in a sex- and region-specific manner.
Regulation (affected) of in brain Transcription (levels) of progesterone receptor in reproductive organ associated with urological neuroanatomy
6) Confidence 0.13 Published 2007 Journal Toxicol. Appl. Pharmacol. Section Abstract Doc Link 17188730 Disease Relevance 0.44 Pain Relevance 0
We investigated effects of pre- and postnatal exposure to 4-MBC in the same rat offspring at brain and reproductive organ levels. 4-MBC (7, 24, 47 mg/kg/day) was administered in chow to the parent generation before mating, during gestation and lactation, and to the offspring until adulthood. mRNA of estrogen target genes involved in control of sexual behavior and gonadal functions was measured by real-time RT-PCR in ventromedial hypothalamic nucleus (VMH) and medial preoptic area (MPO) of adult offspring. 4-MBC exposure affected mRNA levels of ER alpha, progesterone receptor (PR), preproenkephalin (PPE) and insulin-like growth factor-I (IGF-I) in a sex- and region-specific manner.
Regulation (affected) of in brain Transcription (levels) of PR in reproductive organ associated with urological neuroanatomy
7) Confidence 0.13 Published 2007 Journal Toxicol. Appl. Pharmacol. Section Abstract Doc Link 17188730 Disease Relevance 0.45 Pain Relevance 0
Since little is known about their action on gene expression in the adult hypothalamus, we examined the effects of these chemicals on the expression of estrogen-regulated mRNAs, i.e., progesterone receptor (PR) mRNA, preproenkephalin (PPE) mRNA and neurotensin (NT) mRNA, in the hypothalamus and pituitary of adult female rats.
Spec (examined) Regulation (effects) of in hypothalamus Transcription (expression) of progesterone receptor in pituitary
8) Confidence 0.06 Published 2001 Journal Neuroendocrinology Section Abstract Doc Link 11474214 Disease Relevance 0 Pain Relevance 0

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