INT97200

Context Info Confidence 0.52 First Reported 2001 Last Reported 2009 Negated 0 Speculated 0 Reported most in Abstract Documents 3 Total Number 3 Disease Relevance 0.59 Pain Relevance 1.01

nucleus (BHLHE22)

Anatomy Link Frequency myometrium 1 BHLHE22 (Homo sapiens)

Pain Link Frequency Relevance Heat antagonist 1 99.36 Nav1.1 8 95.92 nav1.3 7 94.00 Catecholamine 1 92.72 agonist 6 87.24 Potency 1 82.96 sodium channel 7 82.40 Neuropeptide 3 75.00 Dismenorea 1 75.00 Pain 3 65.04

Disease Link Frequency Relevance Heat Sperm Disorder 15 85.76 Obesity 4 76.72 Dysmenorrhea 1 75.00 Pain 3 64.48 Nociception 1 5.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

The beta 3-AR mRNA was positively expressed in myometrium preparations in a reverse transcription polymerase chain assay.

Transcription (expressed) of beta 3 in myometrium

1) Confidence 0.52 Published 2001 Journal Therapie Section Abstract Doc Link 11475797 Disease Relevance 0.07 Pain Relevance 0.29

Interestingly, NPAF increased the mRNA levels of beta2- and beta3-adrenergic receptors (AR), and to a lesser extent those of beta1-ARs.

Transcription (levels) of beta3

2) Confidence 0.52 Published 2002 Journal J. Biol. Chem. Section Abstract Doc Link 12149260 Disease Relevance 0.28 Pain Relevance 0.29

The mRNAs of the auxiliary subunits beta1, beta3 and beta4 were also present.

Transcription (present) of beta3

3) Confidence 0.16 Published 2009 Journal Reprod Biol Endocrinol Section Abstract Doc Link PMC2724540 Disease Relevance 0.23 Pain Relevance 0.43

General Comments

This test has worked.