INT97208

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Context Info
Confidence 0.07
First Reported 2001
Last Reported 2008
Negated 1
Speculated 0
Reported most in Abstract
Documents 2
Total Number 2
Disease Relevance 0.31
Pain Relevance 1.94

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (Gabrg1, Gabbr1) signal transduction (Gabbr1) transport (Gabrg1)
transcription factor binding (Gabbr1) cytoplasm (Gabbr1) signal transducer activity (Gabbr1)
Anatomy Link Frequency
brain 1
Gabrg1 (Mus musculus)
Gabbr1 (Mus musculus)
Pain Link Frequency Relevance Heat
gABA 26 100.00 Very High Very High Very High
Neurotransmitter 7 99.98 Very High Very High Very High
pregabalin 81 98.74 Very High Very High Very High
anticonvulsant 9 92.80 High High
Analgesic 8 89.04 High High
Pain 40 85.80 High High
Gabapentin 12 72.24 Quite High
sodium channel 1 70.64 Quite High
opiate 3 67.92 Quite High
Serotonin 6 60.96 Quite High
Disease Link Frequency Relevance Heat
Anxiety Disorder 15 94.32 High High
Pain 54 85.80 High High
Epilepsy 5 75.00 Quite High
Fibromyalgia 77 50.00 Quite Low
Depression 17 38.88 Quite Low
Convulsion 3 35.88 Quite Low
Cognitive Disorder 3 32.56 Quite Low
INFLAMMATION 3 29.12 Quite Low
Absence Epilepsy 1 25.00 Low Low
Nociception 1 24.36 Low Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
It has been demonstrated that although pregabalin is a structural derivative of the inhibitory neurotransmitter GABA, it does not bind directly to GABAA, GABAB, or benzodiazepine receptors, does not augment GABAA responses in vitro, does not alter GABA concentration in the animal brain, or have acute effects on GABA uptake or degradation (Lyrica®).
GABA Neg (not) Binding (bind) of GABAB in brain associated with pregabalin, gaba and neurotransmitter
1) Confidence 0.07 Published 2008 Journal Neuropsychiatric Disease and Treatment Section Body Doc Link PMC2646648 Disease Relevance 0.23 Pain Relevance 1.39
GABA interacts with 3 types of receptor: GABAA, GABAB and GABAC.
GABA Binding (interacts) of GABAB associated with gaba
2) Confidence 0.01 Published 2001 Journal CNS Drugs Section Abstract Doc Link 11475940 Disease Relevance 0.07 Pain Relevance 0.55

General Comments

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