INT9721

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Context Info
Confidence 0.26
First Reported 1983
Last Reported 2010
Negated 1
Speculated 1
Reported most in Body
Documents 3
Total Number 8
Disease Relevance 5.97
Pain Relevance 2.38

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (Ptpra)
Anatomy Link Frequency
SK-MEL-3 4
Ptpra (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Catecholamine 2 100.00 Very High Very High Very High
electroacupuncture 9 98.84 Very High Very High Very High
tail-flick 5 98.52 Very High Very High Very High
analgesia 8 98.36 Very High Very High Very High
Dopamine 5 95.42 Very High Very High Very High
Hyperalgesia 5 94.72 High High
monoamine 4 91.36 High High
Antinociceptive 4 86.48 High High
dopamine receptor 1 85.44 High High
Pain 7 83.36 Quite High
Disease Link Frequency Relevance Heat
Cancer 234 99.98 Very High Very High Very High
Shock 61 99.48 Very High Very High Very High
Skin Cancer 96 99.44 Very High Very High Very High
Hyperalgesia 7 96.64 Very High Very High Very High
Stress 42 93.68 High High
Disease 6 91.80 High High
Recurrence 18 90.52 High High
Pain 5 83.36 Quite High
Metastasis 24 81.68 Quite High
Fever 42 75.80 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Inhibition of catecholamine synthesis with alpha-methyl-p-tyrosine (alpha-MPT) antagonized the AEA-induced analgesia measured by the TF test. alpha-MPT did not influence the HP test latency after AEA, and HP or TF tests after stress.
Gene_expression (synthesis) of alpha-methyl-p-tyrosine associated with stress, catecholamine, tail-flick, electroacupuncture and analgesia
1) Confidence 0.26 Published 1983 Journal Biull Eksp Biol Med Section Abstract Doc Link 6313093 Disease Relevance 0.55 Pain Relevance 1.35
Moreover, profound hyperalgesia is revealed by either dopamine (DA) D1 and D2 receptor blockade by means of SCH 23390 [R-(+)-7-chloro-8-hydroxy-3-methyl-1-phenyl-2,3,4,5-tetra-hydro-1H- 3-benzazepine hydrochloride] or (-)-sulpiride, respectively, as well as after a reduction of the presynaptic synthesis of catecholamines after pretreatment of the animals with the tyrosine hydroxylase inhibitor alpha-methyl-DL-p-tyrosine (alpha-MPT).
Gene_expression (synthesis) of alpha-methyl-DL-p-tyrosine associated with dopamine, hyperalgesia and catecholamine
2) Confidence 0.21 Published 1992 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 1432683 Disease Relevance 0.80 Pain Relevance 0.96
On the other hand, increased expression of the chemoresistance-associated transport proteins MRP and LRP was found in melanoma cell lines as well as in primary and metastatic melanoma that could explain resistance towards lipophilic, natural compounds, but not towards alkylating agents [16].
Gene_expression (expression) of LRP associated with skin cancer
3) Confidence 0.05 Published 2010 Journal Journal of Oncology Section Body Doc Link PMC2903950 Disease Relevance 1.00 Pain Relevance 0
The untreated SK-MEL-3 tumor expressed mdr1, mrp1, and lrp, but not mrp2.
Neg (not) Gene_expression (expressed) of lrp in SK-MEL-3 associated with cancer
4) Confidence 0.05 Published 2010 Journal Journal of Oncology Section Abstract Doc Link PMC2903950 Disease Relevance 0.83 Pain Relevance 0
Expression of Chemoresistance Genes

Mdr1, mrp1, and lrp were constantly expressed in the untreated SK-MEL-3 tumor, whereas mrp2-mRNA could not be detected in any of the untreated tumor samples.

Gene_expression (expressed) of lrp in SK-MEL-3 associated with cancer
5) Confidence 0.05 Published 2010 Journal Journal of Oncology Section Body Doc Link PMC2903950 Disease Relevance 0.40 Pain Relevance 0.04
Expression of Chemoresistance Genes

Mdr1, mrp1, and lrp were constantly expressed in the untreated SK-MEL-3 tumor, whereas mrp2-mRNA could not be detected in any of the untreated tumor samples.

Gene_expression (Expression) of lrp in SK-MEL-3 associated with cancer
6) Confidence 0.05 Published 2010 Journal Journal of Oncology Section Body Doc Link PMC2903950 Disease Relevance 0.40 Pain Relevance 0.04
Expression of the chemoresistance genes mdr1, mrp1, mrp2, and lrp and of heat shock protein 72 (HSP72) in the tumor tissue was analysed using RT-PCR and western blot analysis.
Spec (analysed) Gene_expression (Expression) of lrp associated with cancer and shock
7) Confidence 0.05 Published 2010 Journal Journal of Oncology Section Abstract Doc Link PMC2903950 Disease Relevance 0.87 Pain Relevance 0
The SK-MEL-3 tumor constitutively expressed mdr1, mrp1, and lrp.
Gene_expression (expressed) of lrp in SK-MEL-3 associated with cancer
8) Confidence 0.04 Published 2010 Journal Journal of Oncology Section Body Doc Link PMC2903950 Disease Relevance 1.11 Pain Relevance 0

General Comments

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