INT97212

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Context Info
Confidence 0.43
First Reported 1998
Last Reported 2010
Negated 2
Speculated 1
Reported most in Body
Documents 4
Total Number 5
Disease Relevance 3.95
Pain Relevance 1.47

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

biosynthetic process (Gpt) cytoplasm (Gpt)
Anatomy Link Frequency
plasma 2
bile 2
Gpt (Mus musculus)
Pain Link Frequency Relevance Heat
Paracetamol 13 99.58 Very High Very High Very High
Inflammation 41 96.96 Very High Very High Very High
Bile 3 96.48 Very High Very High Very High
fibrosis 42 80.28 Quite High
Inflammatory response 5 59.36 Quite High
metalloproteinase 27 56.12 Quite High
Potency 7 12.24 Low Low
abdominal pain 1 9.68 Low Low
headache 2 6.72 Low Low
cytokine 4 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Hepatitis B Virus Infection 38 98.78 Very High Very High Very High
Body Weight 2 98.20 Very High Very High Very High
Infection 8 97.98 Very High Very High Very High
Chronic Hepatitis 22 97.00 Very High Very High Very High
INFLAMMATION 44 96.96 Very High Very High Very High
Injury 47 96.28 Very High Very High Very High
Necrosis 11 94.12 High High
Chronic Hepatitis B 3 88.08 High High
Congenital Anomalies 4 84.88 Quite High
Liver Disease 6 84.00 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Similarly, sodium sulphate (200 mg/kg) administered alone to PCM-treated mice had no effect on the high mortality rate or the elevation in plasma AST and ALT activities observed in these animals.
Neg (no) Regulation (effect) of Positive_regulation (elevation) of ALT in plasma associated with paracetamol
1) Confidence 0.43 Published 1998 Journal Inflammopharmacology Section Abstract Doc Link 17657622 Disease Relevance 0.14 Pain Relevance 0.70
Marimastat treatment markedly blunts the increase of serum ALT and levels of TNF-?
Regulation (blunts) of Positive_regulation (increase) of serum ALT
2) Confidence 0.23 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2892485 Disease Relevance 1.57 Pain Relevance 0.33
A considerable portion of amatoxin is taken up by hepatocytes, excreted into the bile and reabsorbed by the enterohepatic cycle.24,25 The amatoxins bind to RNA polymerase II and thus inhibit the hepatic formation of mRNA.26 As a result of this, Amanita species cause increases of AST(Aspartate aminotransferase) and ALT(Alanine aminotransferase) levels in the serum.27
Regulation (cause) of Positive_regulation (increases) of ALT in bile associated with bile
3) Confidence 0.19 Published 2010 Journal Clinics (Sao Paulo) Section Body Doc Link PMC2882543 Disease Relevance 0.43 Pain Relevance 0.05
In the rat the elevated serum ALT level was unaffected though the MDA level was similarly reduced by the higher dose of AP.
Neg (unaffected) Regulation (unaffected) of Positive_regulation (elevated) of ALT
4) Confidence 0.13 Published 2001 Journal Life Sci. Section Abstract Doc Link 11476185 Disease Relevance 0.23 Pain Relevance 0.32
HBeAg-positive chronic hepatitis B is regarded as the earliest phase of infection, and patients commonly present with HBV DNA levels exceeding 20,000 IU/mL and with either normal or elevated ALT levels depending on whether the patient is in the immune tolerant or immune clearance phase of infection [10].
Spec (whether) Regulation (depending) of Positive_regulation (elevated) of ALT associated with chronic hepatitis, hepatitis b virus infection and infection
5) Confidence 0.02 Published 2010 Journal Curr Hepat Rep Section Body Doc Link PMC2861769 Disease Relevance 1.58 Pain Relevance 0.06

General Comments

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