INT97216

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Context Info
Confidence 0.45
First Reported 2001
Last Reported 2011
Negated 1
Speculated 0
Reported most in Body
Documents 13
Total Number 13
Disease Relevance 7.04
Pain Relevance 1.25

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (Psd) intracellular (Psd) cytoplasm (Psd)
Anatomy Link Frequency
synapses 2
dentate gyrus 1
Psd (Rattus norvegicus)
Pain Link Frequency Relevance Heat
depression 89 100.00 Very High Very High Very High
Central grey 8 96.56 Very High Very High Very High
Ventral tegmentum 1 89.08 High High
central pain 2 76.60 Quite High
central sensitization 1 75.60 Quite High
Glutamate receptor 14 75.00 Quite High
Spinal cord 3 75.00 Quite High
Pain 11 72.64 Quite High
Neuronal excitability 1 68.92 Quite High
allodynia 1 66.00 Quite High
Disease Link Frequency Relevance Heat
Dementia 109 100.00 Very High Very High Very High
Depression 102 100.00 Very High Very High Very High
Aids-related Complex 70 100.00 Very High Very High Very High
Stroke 152 98.28 Very High Very High Very High
Primary Sclerosing Cholangitis 19 97.52 Very High Very High Very High
Urological Neuroanatomy 13 96.56 Very High Very High Very High
Nicotine Addiction 27 93.12 High High
Injury 50 93.00 High High
Hypertension 11 92.40 High High
Coronary Artery Disease 5 90.96 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The group I subtype mGluR1 was increased over control levels in segments rostral and caudal by postsurgical day (PSD) 7 and remained elevated through PSD 60.
Positive_regulation (elevated) of PSD
1) Confidence 0.45 Published 2001 Journal Exp. Neurol. Section Abstract Doc Link 11476590 Disease Relevance 1.01 Pain Relevance 0.52
Moreover, recent longitudinal studies observed not only that frequency PSD increases in prevalence over the initial weeks post-stroke, in particular within three months from stroke, despite an improvement in disability (Andersen et al 1994b; Aben et al 2003; Paolucci et al 2006), but also that patients with early onset PSD were not necessarily affected later and vice versa, indicating the dynamic nature of PSD in the early stages.
Positive_regulation (increases) of PSD associated with depression and stroke
2) Confidence 0.41 Published 2008 Journal Neuropsychiatric Disease and Treatment Section Body Doc Link PMC2515899 Disease Relevance 1.05 Pain Relevance 0.32
Finally, although reductions in network activity levels were generally associated with increases in PSD size (Figure 5), we practically never observed (except one time point for one cell) a positive relationship between PSD size and the extent to which PSD size changed following reductions in activity levels.
Positive_regulation (increases) of PSD
3) Confidence 0.35 Published 2009 Journal PLoS Biology Section Body Doc Link PMC2693930 Disease Relevance 0 Pain Relevance 0.06
This observation strongly argues against the possibility that increases in PSD size following reductions in activity levels can be viewed as simple multiplicative scaling.


Positive_regulation (increases) of PSD
4) Confidence 0.35 Published 2009 Journal PLoS Biology Section Body Doc Link PMC2693930 Disease Relevance 0 Pain Relevance 0
CONCLUSION: This preliminary study showed that PSD597 was effective for providing sustained amelioration of symptoms of IC/PBlS beyond the acute treatment phase.
Positive_regulation (effective) of PSD597
5) Confidence 0.32 Published 2009 Journal BJU Int. Section Body Doc Link 19021619 Disease Relevance 0 Pain Relevance 0
Furthermore, Western blot analysis of dentate gyrus homogenates demonstrated concomitant upregulation of three postsynaptic density proteins (Arc, PSD-95, and ?
Positive_regulation (upregulation) of PSD in dentate gyrus associated with aids-related complex
6) Confidence 0.28 Published 2008 Journal Neural Plasticity Section Abstract Doc Link PMC2631155 Disease Relevance 0.33 Pain Relevance 0
Although many studies have been conducted for identification of vascular risk factors for PSD, however, their findings were inconsistent and controversial.
Positive_regulation (conducted) of PSD associated with dementia
7) Confidence 0.28 Published 2009 Journal Neuropsychiatric Disease and Treatment Section Body Doc Link PMC2695209 Disease Relevance 2.41 Pain Relevance 0.03
In addition to being itself a target of UPS degradation [3], Shank1A is localized to synapses, and its accumulation requires other scaffold proteins in the PSD, including GKAP, Homer, and PSD-95 [16], [17], [25].
Positive_regulation (requires) of PSD in synapses
8) Confidence 0.19 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2844417 Disease Relevance 0.19 Pain Relevance 0
If a specific E3 mediates the ubiquitination and degradation of a PSD protein, then that PSD protein should accumulate to higher levels when expression of the endogenous E3 is suppressed by RNAi.
Positive_regulation (accumulate) of PSD protein
9) Confidence 0.18 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2844417 Disease Relevance 0.24 Pain Relevance 0
In addition to being itself a target of UPS degradation [3], Shank1A is localized to synapses, and its accumulation requires other scaffold proteins in the PSD, including GKAP, Homer, and PSD-95 [16], [17], [25].
Positive_regulation (requires) of PSD in synapses
10) Confidence 0.17 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2844417 Disease Relevance 0.19 Pain Relevance 0
However, the number of Fos+ cells was significantly increased compared to the PSD animals only in the dorsolateral (dlPAG) and dorsomedial (dmPAG) subdivisions of the PAG (Table 1).
Positive_regulation (increased) of PSD associated with central grey
11) Confidence 0.13 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2629845 Disease Relevance 0.80 Pain Relevance 0.24
Fluoxetine significantly improved PSEI and PSAP, whereas no definitive improvement of PSD was found.
Neg (no) Positive_regulation (improvement) of PSD
12) Confidence 0.13 Published 2006 Journal Stroke Section Body Doc Link 16306470 Disease Relevance 0 Pain Relevance 0
Of the 100 injured workers that underwent EFA testing 56% were female and 44% male.
Positive_regulation (underwent) of EFA
13) Confidence 0.01 Published 2011 Journal J Occup Med Toxicol Section Body Doc Link PMC3022622 Disease Relevance 0.82 Pain Relevance 0.07

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